Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation.
暂无分享,去创建一个
J. Pascussi | J. Pascussi | M. Vilarem | P. Maurel | S. Gerbal-Chaloin | M. Vilarem | J. Fabre | Jean-Michel Fabre
[1] J. Pascussi,et al. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. , 2000, Molecular pharmacology.
[2] L. Moore,et al. Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands* , 2000, The Journal of Biological Chemistry.
[3] E. Schuetz,et al. The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver. , 2000, Drug metabolism and disposition: the biological fate of chemicals.
[4] B. Goodwin,et al. The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module. , 1999, Molecular pharmacology.
[5] K. Griffin,et al. Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors. , 1999, Molecular pharmacology.
[6] D. Waxman,et al. P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. , 1999, Archives of biochemistry and biophysics.
[7] T. Kawamoto,et al. Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene , 1999, Molecular and Cellular Biology.
[8] J. Pascussi,et al. Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene. , 1999, Biochemical and biophysical research communications.
[9] Paavo Honkakoski,et al. The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene* , 1999, The Journal of Biological Chemistry.
[10] T. Nagaya,et al. Glucocorticoids increase retinoid-X receptor alpha (RXRalpha) expression and enhance thyroid hormone action in primary cultured rat hepatocytes. , 1999, Journal of molecular endocrinology.
[11] E. Schuetz,et al. Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element. , 1998, Molecular pharmacology.
[12] W. Sabbagh,et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. , 1998, Genes & development.
[13] R Ohlsson,et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[14] David D. Moore,et al. Androstane metabolites bind to and deactivate the nuclear receptor CAR-β , 1998, Nature.
[15] T. Sueyoshi,et al. The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene , 1998, Molecular and Cellular Biology.
[16] J. Lehmann,et al. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. , 1998, The Journal of clinical investigation.
[17] B. Kemper,et al. Nuclear factor-1 motif and redundant regulatory elements comprise phenobarbital-responsive enhancer in CYP2B1/2. , 1998, DNA and cell biology.
[18] S. Dubois,et al. The CYP2B2 Phenobarbital Response Unit Contains an Accessory Factor Element and a Putative Glucocorticoid Response Element Essential for Conferring Maximal Phenobarbital Responsiveness* , 1998, The Journal of Biological Chemistry.
[19] M. Negishi,et al. Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes. , 1998, The Biochemical journal.
[20] J. Lehmann,et al. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway , 1998, Cell.
[21] M. Negishi,et al. Regulatory DNA elements of phenobarbital‐responsive cytochrome P450 CYP2B genes , 1998, Journal of biochemical and molecular toxicology.
[22] J. Gustafsson,et al. Identification of a functional glucocorticoid response element in the CYP3A1/IGC2 gene. , 1998, DNA and cell biology.
[23] D. Moore,et al. Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR* , 1997, The Journal of Biological Chemistry.
[24] C. Bonfils,et al. Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture , 1997, Hepatology.
[25] M. Lechner,et al. Glucocorticoid receptor-independent transcriptional induction of cytochrome P450 3A1 by metyrapone and its potentiation by glucocorticoid. , 1996, Molecular pharmacology.
[26] Youngkyu Park,et al. Phenobarbital Induction Mediated by a Distal CYP2B2 Sequence in Rat Liver Transiently Transfected in Situ * , 1996, The Journal of Biological Chemistry.
[27] S. Strom,et al. Use of human hepatocytes to study P450 gene induction. , 1996, Methods in enzymology.
[28] P. Guzelian,et al. A Novel cis-Acting Element in a Liver Cytochrome P450 3A Gene Confers Synergistic Induction by Glucocorticoids plus Antiglucocorticoids * , 1995, The Journal of Biological Chemistry.
[29] J. S. Sidhu,et al. cAMP-associated Inhibition of Phenobarbital-inducible Cytochrome P450 Gene Expression in Primary Rat Hepatocyte Cultures (*) , 1995, The Journal of Biological Chemistry.
[30] J. S. Sidhu,et al. Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes. , 1995, Pharmacogenetics.
[31] C. Bonfils,et al. Oxidative metabolism of lansoprazole by human liver cytochromes P450. , 1995, Molecular pharmacology.
[32] Wolfgang Schmid,et al. Molecular genetic analysis of glucocorticoid signaling during mouse development , 1995, Steroids.
[33] O. MacDougald,et al. Transcriptional regulation of gene expression during adipocyte differentiation. , 1995, Annual review of biochemistry.
[34] J. Auwerx,et al. Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. , 1994, The Journal of biological chemistry.
[35] O. MacDougald,et al. Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue. , 1994, The Journal of biological chemistry.
[36] D. Moore,et al. A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements , 1994, Molecular and cellular biology.
[37] L. Corcos,et al. The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU486. , 1993, Molecular pharmacology.
[38] E. Schuetz,et al. Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel. , 1993, Molecular pharmacology.
[39] W. Fan,et al. Cloning of a mu-class glutathione S-transferase gene and identification of the glucocorticoid regulatory domains in its 5' flanking sequence. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[40] P. Maurel,et al. Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes. , 1992, Molecular pharmacology.
[41] E. Schuetz,et al. Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[42] L. Azároff,et al. Phenobarbital induction of cytochrome P-450 gene expression. , 1992, The Biochemical journal.
[43] P. Luc,et al. Glucocorticoid regulation of a phenobarbital-inducible cytochrome P-450 gene: the presence of a functional glucocorticoid response element in the 5'-flanking region of the CYP2B2 gene. , 1990, Nucleic Acids Research.
[44] S. Morris,et al. Induction of mRNA for phosphoenolpyruvate carboxykinase (GTP) by dexamethasone in cultured rat hepatocytes requires on-going protein synthesis. , 1987, The Biochemical journal.
[45] A. Conney,et al. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture. , 1982, Cancer research.