Can disturbed brain microcirculation cause Alzheimer’s disease?

Recent ultrastructural studies demonstrate characteristic and extensive angioarchitectural distortions of cerebral capillaries in Alzheimer’s brains. Alzheimer’s disease subjects additionally show ...

[1]  Robert P. Friedland,et al.  Alzheimer's disease: Anterior-posterior and lateral hemispheric alterations in cortical glucose utilization , 1985, Neuroscience Letters.

[2]  T Jones,et al.  Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. , 1981, Brain : a journal of neurology.

[3]  M. Harrison,et al.  Red cell deformability is not an independent risk factor in stroke. , 1982, Journal of neurology, neurosurgery, and psychiatry.

[4]  D. Graham,et al.  βA4 amyloid protein deposition in brain after head trauma , 1991, The Lancet.

[5]  D. Benson,et al.  The fluorodeoxyglucose 18F scan in Alzheimer's disease and multi-infarct dementia. , 1983, Archives of neurology.

[6]  C. P. Hughes,et al.  Cerebral blood flow, oxygen utilization, and blood volume in dementia , 1977, Neurology.

[7]  B. Pappas,et al.  Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats , 1992, Brain Research.

[8]  M. Rapport,et al.  Glial fibrillary acidic protein and Alzheimer‐type senile dementia , 1980, Neurology.

[9]  T. Miyakawa,et al.  Ultrastructural Changes of Blood Vessels in the Cerebral Cortex in Alzheimer's Disease , 1987, The Japanese journal of psychiatry and neurology.

[10]  J. Ravens.  Vascular changes in the human senile brain. , 1978, Advances in neurology.

[11]  D. Selkoe,et al.  Amyloid protein and Alzheimer's disease. , 1991, Scientific American.

[12]  Jack P. Antel,et al.  Origin of contralateral reactive gliosis in surgically injured rat cerebral cortex , 1991, Brain Research.

[13]  C. Bruton,et al.  The aftermath of boxing , 1973, Psychological Medicine.

[14]  J. Olson,et al.  Prediction of oxygen transport rates in blood flowing in large capillaries. , 1989, Microvascular research.

[15]  Marcel Ga.  Red cell deformability: physiological, clinical and pharmacological aspects. , 1980 .

[16]  B. Siesjö.  Cell Damage in the Brain: A Speculative Synthesis , 1981, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[17]  T. Miyakawa,et al.  Ultrastructural study of senile plaques and microvessels in the brain with Alzheimer's disease and Down's syndrome. , 1989, Annals of medicine.

[18]  C. Duyckaerts,et al.  Glial fibrillary acidic protein and βA4 protein deposits in temporal lobe of aging brain and senile dementia of the Alzheimer type: Relation with the cognitive state and with quantitative studies of senile plaques and neurofibrillary tangles , 1990, Journal of neuroscience research.

[19]  P. Celsis,et al.  Focal cerebral hypoperfusion and selective cognitive deficit in dementia of the Alzheimer type. , 1987, Journal of Neurology Neurosurgery & Psychiatry.

[20]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[21]  H. Wiśniewski,et al.  Pick's Disease: A Clinical and Ultrastructural Study , 1972 .

[22]  D. Ingvar,et al.  Cognitive Reduction in Presenile Dementia Related to Regional Abnormalities of the Cerebral Blood Flow , 1976, British Journal of Psychiatry.

[23]  S. Harik,et al.  Altered glucose metabolism in microvessels from patients with Alzheimer's disease , 1989, Annals of neurology.

[24]  Robert B. Nelson,et al.  Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage , 1989, Neuron.

[25]  A. Delacourte.  General and dramatic glial reaction in Alzheimer brains , 1990, Neurology.

[26]  L. Alexander,et al.  VASCULAR PATTERN IN VARIOUS LESIONS OF THE HUMAN CENTRAL NERVOUS SYSTEM: STUDIES WITH THE BENZIDINE STAIN , 1938 .

[27]  M. Roth,et al.  The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects , 1968, British Journal of Psychiatry.

[28]  J. Haxby,et al.  Positron emission tomography in Alzheimer's disease , 1986, Neurology.

[29]  D. Neary,et al.  Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia. , 1987, Journal of neurology, neurosurgery, and psychiatry.

[30]  G. V. Van Hoesen,et al.  Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease. , 1990, Progress in brain research.

[31]  A. Chanutin,et al.  Effect of organic and inorganic phosphates on the oxygen equilibrium of human erythrocytes. , 1967, Archives of biochemistry and biophysics.

[32]  A. Scheibel,et al.  Alzheimer's disease as a capillary dementia. , 1989, Annals of medicine.

[33]  N. Gellerstedt.  ZUR KENNTNIS DER HIRNVERÄNDERUNGEN BEI DER NORMALEN ALTERSINVOLUTION , 1935 .

[34]  G. Glenner.  Congophilic microangiopathy in the pathogenesis of Alzheimer's syndrome (presenile dementia). , 1979, Medical hypotheses.

[35]  J. Tuke.  On the Morbid Histology of the Brain and Spinal Cord as Observed in the Insane , 1873, The British and foreign medico-chirurgical review.

[36]  Effect of Flow Split on Separation and Stagnation in A Model Vascular Bifurcation , 1981, Stroke.

[37]  O. Hassler,et al.  CEREBRAL ARTERIAL DEFORMITIES IN RELATION TO SENILE DETERIORATION , 1971, Acta psychiatrica Scandinavica. Supplementum.

[38]  W. Jagust,et al.  The diagnosis of dementia with single photon emission computed tomography. , 1987, Archives of neurology.

[39]  F. Tagliavini,et al.  Coexistence of Alzheimer's amyloid precursor protein and amyloid protein in cerebral vessel walls. , 1990, Laboratory investigation; a journal of technical methods and pathology.

[40]  L. Squire,et al.  Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[41]  J. Haxby,et al.  Heterogeneous anterior‐posterior metabolic patterns in dementia of the Alzheimer type , 1988, Neurology.

[42]  A. Wyler,et al.  Memory and head injury severity. , 1987, Journal of neurology, neurosurgery, and psychiatry.

[43]  W H Oldendorf,et al.  TRANSPORT OF METABOLIC SUBSTRATES THROUGH THE BLOOD‐BRAIN BARRIER 1 , 1977, Journal of neurochemistry.

[44]  G. Deutsch,et al.  Cerebral blood flow in severity‐matched Alzheirner and multi‐infarct patients , 1987, Neurology.

[45]  S. Chien.  Principles and Techniques for Assessing Erythrocyte Deformability , 1978 .

[46]  K. Parker,et al.  Mechanics and imaging of the macrocirculation , 1990, Magnetic resonance in medicine.

[47]  F. Gunz.  Blood Microrheology—Viscosity Factors in Blood Flow, Ischaemia and Thrombosis , 1972 .

[48]  J. Dormandy,et al.  A simple method for measuring erythrocyte deformability. , 1976, Journal of clinical pathology.

[49]  R. Tanzi,et al.  Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex , 1991, Neuroscience Letters.

[50]  M. Esiri,et al.  Alzheimer's disease Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities , 1982, Journal of the Neurological Sciences.

[51]  M. Guest,et al.  Red Blood Cells: Change in Shape in Capillaries , 1963, Science.

[52]  J A Helpern,et al.  In vivo 31P NMR profiles of Alzheimer's disease and multiple subcortical infarct dementia , 1989, Neurology.

[53]  R. L. Rogers,et al.  Decreased cerebral blood flow precedes multi‐infarct dementia, but follows senile dementia of Alzheimer type , 1986, Neurology.

[54]  G. Moonen,et al.  Neurono-glial interactions and neural plasticity. , 1990, Progress in brain research.

[55]  E. Burns,et al.  Changes with age in cerebral capillary morphology , 1981, Neurobiology of Aging.

[56]  Carl W. Cotman,et al.  Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor , 1989, Nature.

[57]  H. Nonaka,et al.  A study on the microvasculature of the cerebral cortex. Fundamental architecture and its senile change in the frontal cortex. , 1986, Laboratory investigation; a journal of technical methods and pathology.

[58]  D. Sparks,et al.  Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease , 1990, Neurobiology of Aging.

[59]  S. Sakuta.  Blood filtrability in cerebrovascular disorders, with special reference to erythrocyte deformability and ATP content. , 1981, Stroke.

[60]  A. Aranibar,et al.  High Blood Viscosity Syndrome in Cerebral Infarction , 1974, Stroke.