Autoantibodies neutralizing thrombopoietin in a patient with amegakaryocytic thrombocytopenic purpura.

Amegakaryocytic thrombocytopenic purpura (AMTP), first reported by Korn,[1][1] is a rare disease characterized by severe thrombocytopenia associated with a total absence or a selective decrease in bone marrow megakaryocytes. Previous studies suggest a variety of pathogenetic mechanisms for AMTP,

[1]  G. Trinchieri,et al.  The interleukin-12-mediated pathway of immune events is dysfunctional in human immunodeficiency virus-infected individuals. , 1999, Blood.

[2]  J. Ceuppens,et al.  Decreased CD40 ligand induction in CD4 T cells and dysregulated IL‐12 production during HIV infection , 1999, Clinical and experimental immunology.

[3]  H. Miyazaki,et al.  Proliferative properties of human umbilical cord blood megakaryocyte progenitor cells to human thrombopoietin. , 1998, Experimental hematology.

[4]  H. Ullum,et al.  Low production of interferon gamma is related to disease progression in HIV infection: evidence from a cohort of 347 HIV-infected individuals. , 1997, AIDS research and human retroviruses.

[5]  E. Helm,et al.  Demonstration of the Th1 to Th2 cytokine shift during the course of HIV‐1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry , 1997, AIDS.

[6]  Y. Hasegawa,et al.  Serum Thrombopoietin (TPO) Levels in Patients with Amegakaryocytic Thrombocytopenia Are much Higher than those with Immune Thrombocytopenic Purpura , 1996, Thrombosis and Haemostasis.

[7]  I P Keet,et al.  Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals: decreased IFN-gamma in the presence of preserved IL-4 production. , 1996, Journal of immunology.

[8]  R. Schooley,et al.  In vitro effect of interleukin-12 on antigen-specific lymphocyte proliferative responses from persons infected with human immunodeficiency virus type 1. , 1996, The Journal of infectious diseases.

[9]  A. Sher,et al.  Molecular analysis of decreased interleukin-12 production in persons infected with human immunodeficiency virus. , 1996, The Journal of infectious diseases.

[10]  T. Harrison,et al.  Role of IL-12 in peripheral blood mononuclear cell responses to fungi in persons with and without HIV infection. , 1996, Journal of immunology.

[11]  A. Matsumoto,et al.  A sensitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders , 1996, British Journal of Haematology.

[12]  N. Casadevall,et al.  Autoantibodies against erythropoietin in a patient with pure red-cell aplasia. , 1996, The New England journal of medicine.

[13]  K. Kaushansky Thrombopoietin: the primary regulator of platelet production. , 1995, Blood.

[14]  G. Bonetta,et al.  Serum levels of interleukin-12 in adult and paediatric patients with HIV-1 infection. , 1995, AIDS.

[15]  E. Maggi,et al.  An alternative view of the Th1/Th2 switch hypothesis in HIV infection. , 1994, AIDS research and human retroviruses.

[16]  J. Fahey,et al.  Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection. , 1993, Journal of immunology.

[17]  R. Hoffman Acquired pure amegakaryocytic thrombocytopenic purpura. , 1991, Seminars in hematology.

[18]  R. Landgraf,et al.  Successful treatment of amegakaryocytic thrombocytopenic purpura with cyclosporine. , 1985, The New England journal of medicine.

[19]  T. Berge,et al.  Congenital Hypoplastic Thrombocytopenia in Rubella Embryopathy , 1963, Acta paediatrica.

[20]  D. Korn Congenital hypoplastic thrombocytopenia. Report of a case and review of the literature. , 1962, American journal of clinical pathology.

[21]  B. Wahrén,et al.  Increased levels of interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) mRNA expressing blood mononuclear cells in human HIV infection. , 1994, Clinical and experimental immunology.