Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.

[1]  A. Snijders,et al.  The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2 , 2016, Cell reports.

[2]  A. D’Andrea,et al.  The Fanconi anaemia pathway: new players and new functions , 2016, Nature Reviews Molecular Cell Biology.

[3]  M. Howard,et al.  The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL* , 2015, The Journal of Biological Chemistry.

[4]  N. Ameziane,et al.  Loss‐of‐Function FANCL Mutations Associate with Severe Fanconi Anemia Overlapping the VACTERL Association , 2015, Human mutation.

[5]  A. Smogorzewska,et al.  SnapShot: Fanconi Anemia and Associated Proteins , 2015, Cell.

[6]  G. Luo,et al.  RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathway , 2014, Nucleic acids research.

[7]  F. Rosselli,et al.  Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility , 2014, Journal of Cell Science.

[8]  Junjie Chen,et al.  Modularized functions of the Fanconi anemia core complex. , 2014, Cell Reports.

[9]  L. Passmore,et al.  The Genetic and Biochemical Basis of FANCD2 Monoubiquitination , 2014, Molecular cell.

[10]  H. Walden,et al.  The Fanconi anemia DNA repair pathway: structural and functional insights into a complex disorder. , 2014, Annual review of biophysics.

[11]  P. Knipscheer,et al.  XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4. , 2014, Molecular cell.

[12]  P. Sung,et al.  Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA , 2014, Nucleic acids research.

[13]  H. Walden,et al.  Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection , 2014, Structure.

[14]  S. West,et al.  Architecture and DNA Recognition Elements of the Fanconi Anemia FANCM-FAAP24 Complex , 2013, Structure.

[15]  A. D’Andrea,et al.  Inactivation of Uaf1 Causes Defective Homologous Recombination and Early Embryonic Lethality in Mice , 2013, Molecular and Cellular Biology.

[16]  A. Sobeck,et al.  Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase , 2012, Nucleic acids research.

[17]  H. Walden,et al.  Towards a Molecular Understanding of the Fanconi Anemia Core Complex , 2012, Anemia.

[18]  H. Kurumizaka,et al.  DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI , 2012, Nucleic acids research.

[19]  Yanbin Zhang,et al.  Fanconi Anemia Complementation Group A (FANCA) Protein Has Intrinsic Affinity for Nucleic Acids with Preference for Single-stranded Forms* , 2011, The Journal of Biological Chemistry.

[20]  A. D’Andrea,et al.  Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. , 2011, Genes & development.

[21]  O. Gileadi,et al.  Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. , 2011, Genes & development.

[22]  J. Naismith,et al.  Mechanism of ubiquitylation by dimeric RING ligase RNF4 , 2011, Nature Structural &Molecular Biology.

[23]  S. Elledge,et al.  Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway , 2011, Science.

[24]  Stephen C. West,et al.  DNA interstrand crosslink repair and cancer , 2011, Nature Reviews Cancer.

[25]  Kay Hofmann,et al.  Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2 , 2010, Cell.

[26]  S. West,et al.  FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia. , 2009, Molecular cell.

[27]  G. Kupfer,et al.  ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function. , 2009, Blood.

[28]  Min Huang,et al.  Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. , 2009, Developmental cell.

[29]  M. Babu,et al.  Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. , 2008, Molecular cell.

[30]  S. Elledge,et al.  FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway , 2008, Nature Structural &Molecular Biology.

[31]  T. Richmond,et al.  MultiBac: Multigene Baculovirus‐Based Eukaryotic Protein Complex Production , 2008, Current protocols in protein science.

[32]  J. Sale,et al.  Deubiquitination of FANCD2 Is Required for DNA Crosslink Repair , 2007, Molecular cell.

[33]  S. Elledge,et al.  Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair , 2007, Cell.

[34]  A. D’Andrea,et al.  Chk1-Mediated Phosphorylation of FANCE Is Required for the Fanconi Anemia/BRCA Pathway , 2007, Molecular and Cellular Biology.

[35]  Weidong Wang,et al.  Evidence for subcomplexes in the Fanconi anemia pathway. , 2006, Blood.

[36]  C. Woods,et al.  Fanconi anaemia complementation group B presenting as X linked VACTERL with hydrocephalus syndrome , 2006, Journal of Medical Genetics.

[37]  Sebastian Maurer-Stroh,et al.  The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates. , 2005, Molecular cell.

[38]  René Bernards,et al.  The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. , 2005, Molecular cell.

[39]  G. Pals,et al.  X-linked inheritance of Fanconi anemia complementation group B , 2004, Nature Genetics.

[40]  C. Bishop,et al.  A novel ubiquitin ligase is deficient in Fanconi anemia , 2003, Nature Genetics.

[41]  A. D’Andrea,et al.  Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants. , 2002, Human molecular genetics.

[42]  A. D’Andrea,et al.  The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC. , 2002, Blood.

[43]  Hans Joenje,et al.  FANCE: the link between Fanconi anaemia complex assembly and activity , 2002, The EMBO journal.

[44]  B. Seed,et al.  Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9. , 2001, Blood.

[45]  A. D’Andrea,et al.  The fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex. , 2000, Blood.

[46]  A. Berns,et al.  Mice with a targeted disruption of the Fanconi anemia homolog Fanca. , 2000, Human molecular genetics.

[47]  Mike Tyers,et al.  F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex , 1997, Cell.

[48]  S. Kaech,et al.  FANCL UBIQUITINATES BETA-CATENIN AND ENHANCES ITS NUCLEAR FUNCTION , 2012 .