Influences of microbiota on intestinal immune system development.

The normal colonization of the mammalian intestine with commensal microbes is hypothesized to drive the development of the humoral and cellular mucosal immune systems during neonatal life and to maintain the physiologically normal steady state of inflammation in the gut throughout life. Neonatal conventionally reared mice and germ-free, deliberately colonized adult mice (gnotobiotic mice) were used to examine the efficacy of certain intestinal microbes.

[1]  K. E. Shroff,et al.  Development and Maintenance of the Gut-Associated Lymphoid Tissue (Galt): the Roles of Enteric Bacteria and Viruses , 1998, Developmental immunology.

[2]  A. George,et al.  Use of Peyer's patch and lymph node fragment cultures to compare local immune responses to Morganella morganii , 1991, Infection and immunity.

[3]  R. Berg,et al.  Immune responses of specific pathogen-free and gnotobiotic mice to antigens of indigenous and nonindigenous microorganisms , 1975, Infection and immunity.

[4]  D. Savage,et al.  A method for harvesting non‐cultivable filamentous segmented microbes inhabiting the ileum of mice , 1987 .

[5]  A. Imaoka,et al.  Segmented Filamentous Bacteria Are Indigenous Intestinal Bacteria That Activate Intraepithelial Lymphocytes and Induce MHC Class II Molecules and Fucosyl Asialo GM1 Glycolipids on the Small Intestinal Epithelial Cells in the Ex‐Germ‐Free Mouse , 1995, Microbiology and immunology.

[6]  S. Craig,et al.  Rabbit Peyer's patches, appendix, and popliteal lymph node B lymphocytes: a comparative analysis of their membrane immunoglobulin components and plasma cell precursor potential. , 1975, Journal of immunology.

[7]  C E Nord,et al.  Problems and priorities for controlling opportunistic pathogens with new antimicrobial strategies; an overview of current literature. , 1996, Zentralblatt fur Bakteriologie : international journal of medical microbiology.

[8]  J. Cebra,et al.  Molecular genetic features reflecting the preference for isotype switching to IgA expression by Peyer's patch germinal center B cells. , 1991, International immunology.

[9]  R. Ducluzeau,et al.  Increase in the Population of Duodenal Immunoglobulin A Plasmocytes in Axenic Mice Associated with Different Living or Dead Bacterial Strains of Intestinal Origin , 1978, Infection and immunity.

[10]  T. Macdonald.  Ontogeny of the Immune System of the Gut , 1990 .

[11]  M. Collins,et al.  Comparison of 16S rRNA sequences of segmented filamentous bacteria isolated from mice, rats, and chickens and proposal of "Candidatus Arthromitus". , 1995, International journal of systematic bacteriology.

[12]  M. Pollard,et al.  Responses of the Peyer's Patches in Germ-Free Mice to Antigenic Stimulation , 1970, Infection and immunity.

[13]  S. Matsumoto,et al.  Effects of fecal microorganisms and their chloroform-resistant variants derived from mice, rats, and humans on immunological and physiological characteristics of the intestines of ex-germfree mice , 1994, Infection and immunity.

[14]  W. Eling,et al.  Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice , 1993, Infection and immunity.

[15]  K. E. Shroff,et al.  13 – Peyer's Patches as Inductive Sites for IgA Commitment , 1994 .

[16]  D. Savage,et al.  Microbial interference and colonization of the murine gastrointestinal tract by Listeria monocytogenes , 1979, Infection and immunity.

[17]  M. Potter.  ANTIGEN‐BINDING MYELOMA PROTEINS IN MICE , 1971, Advances in immunology.

[18]  P. Ogra.  Handbook of mucosal immunology , 1994 .

[19]  N. Pierce,et al.  Cellular kinetics of the intestinal immune response to cholera toxoid in rats , 1975, The Journal of experimental medicine.

[20]  M. Pollard,et al.  Host responses to "normal" microbial flora in germ-free mice. , 1971, Journal of the Reticuloendothelial Society.

[21]  R. Dubos,et al.  THE DEVELOPMENT OF THE BACTERIAL FLORA IN THE GASTROINTESTINAL TRACT OF MICE , 1965, The Journal of experimental medicine.

[22]  A. Beynen,et al.  Mono-association of mice with non-cultivable, intestinal, segmented, filamentous bacteria , 1991, Archives of Microbiology.

[23]  D. Rubin,et al.  Passive immunity to fatal reovirus serotype 3-induced meningoencephalitis mediated by both secretory and transplacental factors in neonatal mice , 1990, Journal of virology.

[24]  J. Cebra,et al.  Role of maternal antibody in the induction of virus specific and bystander IgA responses in Peyer's patches of suckling mice. , 1995, International immunology.

[25]  F. Haurowitz.  Developmental aspects of antibody formation and structure (Proceedings of Symposium held on 1–7 June 1969 in Prague and Slapy)—Edited by J. Sterzl and I. Riha. Akademia Prague 255 Kcs; Academic Press, 1970. 1054 pp. $39.00 , 1972 .

[26]  L. Lefrançois,et al.  Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function , 1989, The Journal of experimental medicine.

[27]  K. E. Shroff,et al.  Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut , 1995, Infection and immunity.

[28]  L. Lefrançois,et al.  In vivo modulation of cytolytic activity and Thy-1 expression in TCR-gamma delta+ intraepithelial lymphocytes. , 1989, Science.

[29]  H. Bazin,et al.  Immunohistochemical observations on lymphoid tissues from conventional and germ-free mice. , 1970, Laboratory investigation; a journal of technical methods and pathology.

[30]  V. Vetvicka,et al.  DEVELOPMENT OF IMMUNOLOGICAL CAPACITY UNDER GERMFREE AND CONVENTIONAL CONDITIONS , 1983, Annals of the New York Academy of Sciences.

[31]  S. Kaufmann,et al.  Listeria monocytogenes-induced gamma interferon secretion by intestinal intraepithelial gamma/delta T lymphocytes , 1993, Infection and immunity.

[32]  J. Kearney,et al.  Functional characterization of monoclonal auto‐antiidiotype antibodies isolated from the early B cell repertoire of BALB/c mice , 1986, European journal of immunology.

[33]  D. Savage,et al.  Habitat, Succession, Attachment, and Morphology of Segmented, Filamentous Microbes Indigenous to the Murine Gastrointestinal Tract , 1974, Infection and immunity.

[34]  R. Dubos,et al.  INDIGENOUS, NORMAL, AND AUTOCHTHONOUS FLORA OF THE GASTROINTESTINAL TRACT , 1965, The Journal of experimental medicine.

[35]  J. Cebra,et al.  The preference for switching to IgA expression by Peyer's patch germinal center B cells is likely due to the intrinsic influence of their microenvironment. , 1991, Journal of immunology.

[36]  J. Cebra,et al.  Rise in Inulin-Sensitive B Cells During Ontogeny Can Be Prematurely Stimulated by Thymus-Dependent and Thymus-Independent Antigens , 1981, Infection and immunity.

[37]  D. Rubin,et al.  Gut mucosal immunization with reovirus serotype 1/L stimulates virus- specific cytotoxic T cell precursors as well as IgA memory cells in Peyer's patches , 1987, The Journal of experimental medicine.

[38]  F. Kovářů,et al.  Development of immune responses in early pig ontogeny. , 1994, Veterinary immunology and immunopathology.

[39]  T. Speaker,et al.  Orally administered microencapsulated reovirus can bypass suckled, neutralizing maternal antibody that inhibits active immunization of neonates , 1997, Journal of virology.

[40]  J. Cebra,et al.  Early appearance of "natural" mucosal IgA responses and germinal centers in suckling mice developing in the absence of maternal antibodies. , 1995, Journal of immunology.

[41]  A. Carroll,et al.  The SCID mouse mutant: definition, characterization, and potential uses. , 1991, Annual review of immunology.

[42]  H. Tlaskalova-Hogenova,et al.  Development of antibody formation in germ-free and conventionally reared rabbits: the role of intestinal lymphoid tissue in antibody formation to E. coli antigens. , 1980, Folia biologica.

[43]  H. Bazin,et al.  The normal microbial flora as a major stimulus for proliferation of plasma cells synthesizing IgA in the gut. The germ-free intestinal tract. , 1968, International archives of allergy and applied immunology.

[44]  W. Eling,et al.  Interactions between gut-associated lymphoid tissue and colonization levels of indigenous, segmented, filamentous bacteria in the small intestine of mice. , 1998, Canadian journal of microbiology.

[45]  P. Krajči,et al.  10 – Epithelial and Hepatobiliary Transport of Polymeric Immunoglobulins , 1994 .