In this manuscript we intend to analyze how blockchain technology can improve supply chain variables and technology transfer in medium-sized enterprises from IT&C sector. Blockchain technology is expected to enhance the velocity and reliability of business and managerial processes and increase competitiveness for IT&C companies. We sought to see if these combined elements lead to the generation of competitive advantage, which in turn influences the firm performance. Based on the study of relevant literature, we developed a conceptual and methodological framework and test it on 383 medium-sized companies from IT&C sector, using the Confirmatory Factor Analysis. The results of the study show that blockchain technology positively influences supply chain variables and technology transfer, with direct effects on the firm performance