Dynamics of G protein effector interactions and their impact on timing and sensitivity of G protein-mediated signal transduction.
暂无分享,去创建一个
[1] M. Bünemann,et al. Influence of Gαq on the Dynamics of M3-Acetylcholine Receptor–G-Protein–Coupled Receptor Kinase 2 Interaction , 2015, Molecular Pharmacology.
[2] M. Bünemann,et al. Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors , 2014, Nature Communications.
[3] T. Wieland,et al. Dynamics of Gαq-protein-p63RhoGEF interaction and its regulation by RGS2. , 2014, The Biochemical journal.
[4] M. Bünemann,et al. Dynamics of Gαi1 interaction with type 5 adenylate cyclase reveal the molecular basis for high sensitivity of Gi-mediated inhibition of cAMP production. , 2013, The Biochemical journal.
[5] G. Skiniotis,et al. Full-Length Gαq–Phospholipase C-β3 Structure Reveals Interfaces of the C-terminal Coiled-Coil Domain , 2013, Nature Structural &Molecular Biology.
[6] T. Hughes,et al. Simultaneous Detection of Ca2+ and Diacylglycerol Signaling in Living Cells , 2012, PloS one.
[7] U. Zabel,et al. Comparison of the Activation Kinetics of the M3 Acetylcholine Receptor and a Constitutively Active Mutant Receptor in Living Cells , 2012, Molecular Pharmacology.
[8] R. Neubig,et al. Assembly of High Order Gαq-Effector Complexes with RGS Proteins* , 2008, Journal of Biological Chemistry.
[9] R. Neubig,et al. Structure of Gαq-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs , 2007, Science.
[10] M. Lohse,et al. Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. , 2007, The Journal of clinical investigation.
[11] M. Lohse,et al. GS Activation Is Time-limiting in Initiating Receptor-mediated Signaling* , 2006, Journal of Biological Chemistry.
[12] T. Kozasa,et al. Snapshot of Activated G Proteins at the Membrane: The Gαq-GRK2-Gßγ Complex , 2005, Science.
[13] M. Lohse,et al. Dynamics of receptor/G protein coupling in living cells , 2005, The EMBO journal.
[14] M. Lohse,et al. G Protein Activation without Subunit Dissociation Depends on a Gαi-specific Region* , 2005, Journal of Biological Chemistry.
[15] Mark H Ellisman,et al. A FlAsH-based FRET approach to determine G protein–coupled receptor activation in living cells , 2005, Nature Methods.
[16] J. Benovic,et al. Characterization of the GRK2 Binding Site of Gαq* , 2004, Journal of Biological Chemistry.
[17] T. Wieland,et al. p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.
[18] M. Lohse,et al. Gi protein activation in intact cells involves subunit rearrangement rather than dissociation , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[19] M. Lohse,et al. Measurement of the millisecond activation switch of G protein–coupled receptors in living cells , 2003, Nature Biotechnology.
[20] M. Lohse,et al. Activation and Deactivation Kinetics of α2A- and α2C-Adrenergic Receptor-activated G Protein-activated Inwardly Rectifying K+ Channel Currents* , 2001, The Journal of Biological Chemistry.
[21] P. Devreotes,et al. Receptor-Mediated Activation of Heterotrimeric G-Proteins in Living Cells , 2001, Science.
[22] S. Sprang,et al. Identification of a Giα Binding Site on Type V Adenylyl Cyclase* , 1998, The Journal of Biological Chemistry.
[23] Heidi E. Hamm,et al. The Many Faces of G Protein Signaling* , 1998, The Journal of Biological Chemistry.
[24] H. Lester,et al. RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K+ channels , 1997 .
[25] R. Sunahara,et al. Interaction of Gsα with the Cytosolic Domains of Mammalian Adenylyl Cyclase* , 1997, The Journal of Biological Chemistry.
[26] S. Sprang,et al. Structure of RGS4 Bound to AlF4 −-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis , 1997, Cell.
[27] R. Stoffel,et al. Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[28] L. Pott,et al. Downregulation of muscarinic M2 receptors linked to K+ current in cultured guinea‐pig atrial myocytes. , 1996, The Journal of physiology.
[29] R. Fischmeister,et al. Differential effects of pertussis toxin on the muscarinic regulation of Ca2+ and K+ currents in frog cardiac myocytes , 1994, The Journal of general physiology.
[30] R. Lefkowitz,et al. Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. , 1994, The Journal of biological chemistry.
[31] M. Berridge,et al. Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells. , 1984, The Biochemical journal.
[32] A. Gilman,et al. The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins. , 1983, The Journal of biological chemistry.
[33] E. Hewlett,et al. Identification of the predominant substrate for ADP-ribosylation by islet activating protein. , 1983, The Journal of biological chemistry.
[34] Moritoshi Sato. Genetically encoded fluorescent biosensors for live cell imaging of lipid dynamics. , 2014, Methods in molecular biology.
[35] J. Tesmer,et al. Strike a pose: Gαq complexes at the membrane. , 2014, Trends in pharmacological sciences.
[36] J. Hanoune,et al. Regulation and role of adenylyl cyclase isoforms. , 2001, Annual review of pharmacology and toxicology.
[37] M. Michel,et al. Receptor systems in the non-failing human heart. , 1992, Basic research in cardiology.
[38] Y. Hannun,et al. Mechanism of regulation of protein kinase C by lipid second messengers. , 1986, Symposium on Fundamental Cancer Research.