A concise synthesis of [carbonyl‐11C]melatonin and N‐[carbonyl‐ 11C]acetylserotonin

Rapid chemical syntheses of [carbonyl- 11C]melatonin and N-[carbonyl- 11C]acetylserotonin starting from [11C]carbon dioxide are described. The radiochemical yield (based on [carbonyl-11C]-acetic acid), purity, and the specific activity (end of bombardment) of the former are 12%, >98%, and 4.2 Ci/μmol, respectively. The latter is also synthesized with the same radiochemical yield, purity, and specific activity. The total times required for their syntheses are ca. 45 min, respectively.

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