Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma.

[1]  R. Verhaak,et al.  Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process , 2014, Proceedings of the National Academy of Sciences.

[2]  Franziska Michor,et al.  Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma. , 2014, Cancer cell.

[3]  Shawn M. Gillespie,et al.  Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma , 2014, Science.

[4]  A. Becker,et al.  Contribution of Tumor Heterogeneity in a New Animal Model of CNS Tumors , 2014, Molecular Cancer Research.

[5]  R. Dixit,et al.  RAS/ERK Signaling Controls Proneural Genetic Programs in Cortical Development and Gliomagenesis , 2014, The Journal of Neuroscience.

[6]  Christof Fellmann,et al.  An optimized microRNA backbone for effective single-copy RNAi. , 2013, Cell reports.

[7]  Barbara S. Paugh,et al.  Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. , 2013, Cancer research.

[8]  L. Hood,et al.  Evolutionary etiology of high-grade astrocytomas , 2013, Proceedings of the National Academy of Sciences.

[9]  D. Haussler,et al.  The Somatic Genomic Landscape of Glioblastoma , 2013, Cell.

[10]  V. P. Collins,et al.  Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics , 2013, Proceedings of the National Academy of Sciences.

[11]  F. Biagioni,et al.  Rapamycin inhibits the growth of glioblastoma , 2013, Brain Research.

[12]  J. Barnholtz-Sloan,et al.  CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. , 2012, Neuro-oncology.

[13]  W. Snider,et al.  MEK Is a Key Regulator of Gliogenesis in the Developing Brain , 2012, Neuron.

[14]  Long-Sheng Chang,et al.  ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities , 2012, Cell.

[15]  Tzong-Shiue Yu,et al.  A restricted cell population propagates glioblastoma growth following chemotherapy , 2012, Nature.

[16]  Joshua J. Breunig,et al.  Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation , 2012, Neural Development.

[17]  D. Gutmann,et al.  Innate neural stem cell heterogeneity determines the patterning of glioma formation in children. , 2012, Cancer cell.

[18]  A. Burlingame,et al.  A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. , 2012, Genes & development.

[19]  T. Jiang,et al.  MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2 , 2012, Journal of Cancer Research and Clinical Oncology.

[20]  L. Parada,et al.  Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells , 2012, Cell.

[21]  David T. W. Jones,et al.  Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma , 2012, Nature.

[22]  P. Canoll,et al.  MADM gives new insights into gliomagenesis. , 2011, Journal of molecular cell biology.

[23]  Noemi Andor,et al.  Asymmetry-defective oligodendrocyte progenitors are glioma precursors. , 2011, Cancer cell.

[24]  Sutapa Banerjee,et al.  Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner , 2011, Proceedings of the National Academy of Sciences.

[25]  L. Luo,et al.  Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma , 2011, Cell.

[26]  T. Ludwig,et al.  Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural Phenotype , 2011, PloS one.

[27]  Johannes Zuber,et al.  A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference , 2011, Cell.

[28]  Jane E. Visvader,et al.  Cells of origin in cancer , 2011, Nature.

[29]  M. Berger,et al.  Non-stem cell origin for oligodendroglioma. , 2010, Cancer cell.

[30]  A. Kriegstein,et al.  Developmental genetics of vertebrate glial–cell specification , 2010, Nature.

[31]  D. Gutmann,et al.  Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner. , 2010, Genes & development.

[32]  C. Brennan,et al.  PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas. , 2010, Genes & development.

[33]  Richard Kemp,et al.  Characterization of a heat resistant ß-glucosidase as a new reporter in cells and mice , 2010, BMC Biology.

[34]  Andrew D Norden,et al.  Recurrent High-Grade Glioma , 2010, Current treatment options in neurology.

[35]  T. Haydar,et al.  Heterogeneity in Ventricular Zone Neural Precursors Contributes to Neuronal Fate Diversity in the Postnatal Neocortex , 2010, The Journal of Neuroscience.

[36]  S. Gabriel,et al.  Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. , 2010, Cancer cell.

[37]  L. Parada,et al.  Signaling in Malignant Astrocytomas: Role of Neural Stem Cells and Its Therapeutic Implications , 2009, Clinical Cancer Research.

[38]  Y. Wang,et al.  Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. , 2009, Cancer cell.

[39]  Jing Ma,et al.  Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas , 2009, The Journal of pathology.

[40]  R. Mirimanoff,et al.  Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. , 2009, The Lancet. Oncology.

[41]  James E. Goldman,et al.  The interface between glial progenitors and gliomas , 2008, Acta Neuropathologica.

[42]  Joshua M. Korn,et al.  Comprehensive genomic characterization defines human glioblastoma genes and core pathways , 2008, Nature.

[43]  R. Mason,et al.  Pten haploinsufficiency accelerates formation of high-grade astrocytomas. , 2008, Cancer research.

[44]  S A Forbes,et al.  The Catalogue of Somatic Mutations in Cancer (COSMIC) , 2008, Current protocols in human genetics.

[45]  Y. Xing,et al.  A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function , 2008, The Journal of Neuroscience.

[46]  P. Rakic,et al.  Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus , 2007, Proceedings of the National Academy of Sciences.

[47]  D. Gutmann,et al.  Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. , 2007, Cell stem cell.

[48]  C. Weiller,et al.  Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma. , 2007, Neuropediatrics.

[49]  C. Cepko,et al.  Controlled expression of transgenes introduced by in vivo electroporation , 2007, Proceedings of the National Academy of Sciences.

[50]  M. Assanah,et al.  Glial Progenitors in Adult White Matter Are Driven to Form Malignant Gliomas by Platelet-Derived Growth Factor-Expressing Retroviruses , 2006, The Journal of Neuroscience.

[51]  M. Watson,et al.  RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma , 2005, Neurology.

[52]  Dawen Zhao,et al.  Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. , 2005, Cancer cell.

[53]  D. Gutmann,et al.  Neurofibromin Regulates Neural Stem Cell Proliferation, Survival, and Astroglial Differentiation In Vitro and In Vivo , 2005, The Journal of Neuroscience.

[54]  D. Gutmann,et al.  Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes. , 2005, Cancer research.

[55]  Y. Tanabe,et al.  Laminar Patterning in the Developing Neocortex by Temporally Coordinated Fibroblast Growth Factor Signaling , 2004, The Journal of Neuroscience.

[56]  Pasko Rakic,et al.  Elusive radial glial cells: Historical and evolutionary perspective , 2003, Glia.

[57]  J. Marth,et al.  Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. , 2001, Genes & development.

[58]  K. Mishima,et al.  Expression of galectin‐1 mRNA correlates with the malignant potential of human gliomas and expression of antisense galectin‐1 inhibits the growth of 9 glioma cells , 2000, Journal of neuroscience research.

[59]  S. McWeeney,et al.  Cancer stem cell tumor model reveals invasive morphology and increased phenotypical heterogeneity. , 2010, Cancer research.