The invention provides an arrangement method of an active anti-overturning mechanical synchronizing system for an anti-overturning hydraulic power type ship lift. The rigidity and strength of synchronizing shafts of the active anti-overturning mechanical synchronizing system are set and gaps and manufacturing errors of the active anti-overturning mechanical synchronizing system are controlled, so that the active anti-overturning mechanical synchronizing system simultaneously has the ship lift chamber anti-overturning function and the uneven ship lift chamber load evenly-transmission function; when a ship lift chamber bears the uneven load and inclines, the anti-overturning force moment can be actively generated for the ship lift chamber through tiny deformation of the active anti-overturning mechanical synchronizing system, and the purposes that the inclination of the ship lift chamber is controlled and the torque of the synchronizing shafts is reduced are achieved; and when the inclination of the ship lift chamber or the torque of the synchronizing system reaches a designed value, rotation of a coiling block is locked through a brake of the active anti-overturning mechanical synchronizing system, the overall safety of the ship lift chamber is guaranteed, and safe and reliable operation of the hydraulic power type ship lift can be guaranteed.