Man-made mineral (vitreous) fibres: evaluations of cancer hazards by the IARC Monographs Programme.

Man-made vitreous (glass-like) fibres are non-crystalline, fibrous inorganic substances (silicates) made primarily from rock, slag, glass or other processed minerals. These materials, also called man-made mineral fibres, include glass fibres (used in glass wool and continuous glass filament), rock or stone wool, slag wool and refractory ceramic fibres. They are widely used for thermal and acoustical insulation and to a lesser extent for other purposes. These products are potentially hazardous to human health because they release airborne respirable fibres during their production, use and removal. Man-made mineral fibres and man-made vitreous fibres have been the subject of reviews by IARC Monographs Working Groups in 1987 and 2001, respectively, which resulted in evaluations of the carcinogenic hazard to humans from exposure to these materials. These reviews and evaluations have been published as Volumes 43 and 81 of the IARC Monographs series [IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 43, Man-made Mineral Fibres and Radon (1988); IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 81, Man-made Vitreous Fibres (2002)]. The re-evaluation in 2001 was undertaken because there have been substantial improvements in the quality of the epidemiological information available on the carcinogenicity to humans of glass fibres, continuous glass filament and rock/slag wool. The new evaluations have addressed the limitations of earlier cohort studies, particularly concerning the lack of adjustment with respect to concomitant risk factors such as smoking and other sources of occupational exposure. In addition, the evaluation of the evidence for carcinogenicity of glass fibres to experimental animals has been refined, by making a distinction between insulation glass wool and special-purpose glass fibres. The results of the evaluations in 1987 and 2001 are thus different in several aspects. In this paper, the reviews and evaluations of the carcinogenic hazards of exposure to man-made mineral fibres (MMMF, Monograph volume 43, [1]) and man-made vitreous fibres (MMVF, Monograph volume 81, [2]) are summarised, and the differences explained. In particular, the considerations of the respective IARC Monographs Working Groups (1987, 2001) in reaching their conclusions are discussed in some detail.

[1]  L. Maxim,et al.  Interspecies comparisons of the toxicity of asbestos and synthetic vitreous fibers: a weight-of-the-evidence approach. , 2001, Regulatory toxicology and pharmacology : RTP.

[2]  D M Bernstein,et al.  Biopersistence of synthetic mineral fibers as a predictor of chronic inhalation toxicity in rats. , 2001, Inhalation toxicology.

[3]  H. Cowie,et al.  The relationship between fibrosis and cancer in experimental animals exposed to asbestos and other fibers. , 1990, Environmental health perspectives.

[4]  S. Adachi,et al.  Tumorigenicity of fine man-made fibers after intratracheal administrations to hamsters. , 1991, Environmental research.

[5]  P. Thevenaz,et al.  Chronic Inhalation Study of Size-Separated Rock and Slag Wool Insulation Fibers in Fischer 344/N Rats , 1994 .

[6]  F. Huth,et al.  ANIMAL EXPERIMENTS WITH CHEMICALLY TREATED FIBRES , 1988 .

[7]  M. Stanton,et al.  Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. , 1977, Journal of the National Cancer Institute.

[8]  R. S. Waritz,et al.  Comparative pulmonary responses to inhaled inorganic fibers with asbestos and fiberglass. , 1981, Environmental research.

[9]  Gary E Marchant,et al.  A synthetic vitreous fiber (SVF) occupational exposure database: implementing the SVF Health and Safety Partnership Program. , 2002, Applied occupational and environmental hygiene.

[10]  Thomas J. Smith,et al.  Historical Cohort Study of US Man-Made Vitreous Fiber Production Workers: III. Analysis of Exposure-Weighted Measures of Respirable Fibers and Formaldehyde in the Nested Case-Control Study of Respiratory System Cancer , 2001, Journal of occupational and environmental medicine.

[11]  L. D. Maxim,et al.  CARE : A European programme for monitoring and reducing refractory ceramic fibre dust at the workplace : Initial results , 1998 .

[12]  C. P. Yu,et al.  Deposition of fibers in the rat lung , 1989 .

[13]  A case-control study of lung cancer in a cohort of workers potentially exposed to slag wool fibres. , 1991, British journal of industrial medicine.

[14]  J Dodgson,et al.  The International Agency for Research on Cancer historical cohort study of MMMF production workers in seven European countries: extension of the follow-up. , 1987, The Annals of occupational hygiene.

[15]  M. Roller,et al.  Results of current intraperitoneal carcinogenicity studies with mineral and vitreous fibres. , 1996, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[16]  B. Terracini.  Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. , 1975 .

[17]  T. Hesterberg,et al.  Synthetic Vitreous Fibers: A Review of Toxicology Research and Its Impact on Hazard Classification , 2001, Critical reviews in toxicology.

[18]  L. R. Glass,et al.  Chronic Inhalation Toxicity of a Kaolin-Based Refractory Ceramic Fiber in Syrian Golden Hamsters , 1995 .

[19]  M B Snipes,et al.  Long-term retention and clearance of particles inhaled by mammalian species. , 1989, Critical reviews in toxicology.

[20]  H. Shannon,et al.  Mortality of glass filament (textile) workers. , 1990, British journal of industrial medicine.

[21]  F. Huth,et al.  Carcinogenicity studies on fibres, metal compounds, and some other dusts in rats. , 1987, Experimental pathology.

[22]  F. Huth,et al.  [Results of animal experiments concerning the carcinogenic effect of fibrous dusts and their interpretation with regard to the carcinogenesis in humans (author's transl)]. , 1976, Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin.

[23]  T. Tlsty,et al.  Stromal cells can contribute oncogenic signals. , 2001, Seminars in cancer biology.

[24]  R. Stone,et al.  Historical Cohort Study of US Man-Made Vitreous Fiber Production Workers: IV. Quantitative Exposure-Response Analysis of the Nested Case-Control Study of Respiratory System Cancer , 2001, Journal of occupational and environmental medicine.

[25]  C. P. Yu,et al.  Alveolar deposition of fibers in rodents and humans. , 1998, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[26]  W. Kreyling,et al.  Phagolysosomal morphology and dissolution of cobalt oxide particles by human and rabbit alveolar macrophages. , 1995, Experimental lung research.

[27]  I. Webster,et al.  A comparison of the effects of exposure of baboons to crocidolite and fibrous-glass dusts. , 1983, Environmental research.

[28]  G. Berry.  Models for mesothelioma incidence following exposure to fibers in terms of timing and duration of exposure and the biopersistence of the fibers. , 1999, Inhalation toxicology.

[29]  G. Oberdörster,et al.  Determinants of the pathogenicity of man-made vitreous fibers (MMVF) , 2000, International archives of occupational and environmental health.

[30]  H S Shannon,et al.  Mortality experience of Ontario glass fibre workers--extended follow-up. , 1987, The Annals of occupational hygiene.

[31]  P. Thévenaz,et al.  Chronic inhalation toxicity of size-separated glass fibers in Fischer 344 rats. , 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[32]  T. Schneider,et al.  Ubiquitous fiber exposure in selected sampling sites in Europe. , 1996, Scandinavian journal of work, environment & health.

[33]  M. Roller,et al.  Tumours by the Intraperitoneal and Intrapleural Routes and their Significance for the Classification of Mineral Fibres , 1991 .

[34]  J. M. Davis,et al.  Pathogenicity of a special-purpose glass microfiber (E glass) relative to another glass microfiber and amosite asbestos. , 2000, Inhalation toxicology.

[35]  S. Krantz.  Exposure to man-made mineral fibers at ten production plants in Sweden. , 1988, Scandinavian journal of work, environment & health.

[36]  S. Takenaka,et al.  Inhalation and injection experiments in rats to test the carcinogenicity of MMMF. , 1987, The Annals of occupational hygiene.

[37]  J. Wagner,et al.  Mesotheliomata in Rats after Inoculation with Asbestos and Other Materials , 1973 .

[38]  P. Germann,et al.  Lung Tumours in Rats after Intratracheal Instillation of Dusts , 1994 .

[39]  L. Coussens,et al.  Inflammation and cancer , 2002, Nature.

[40]  L. Coussens,et al.  Inflammatory Cells and Cancer , 2001, The Journal of experimental medicine.

[41]  D. K. Watkins,et al.  Historical cohort mortality study of a continuous filament fiberglass manufacturing plant. I. White men. , 1997, Journal of occupational and environmental medicine.

[42]  M. Stanton,et al.  Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. , 1981, Journal of the National Cancer Institute.

[43]  G. Marsh,et al.  Mortality update of a cohort of U.S. man-made mineral fibre workers. , 1987, The Annals of occupational hygiene.

[44]  P. Thévenaz,et al.  Chronic inhalation study of fiber glass and amosite asbestos in hamsters: twelve-month preliminary results. , 1997, Environmental health perspectives.

[45]  J Dodgson,et al.  The man-made mineral fiber European historical cohort study. Extension of the follow-up. , 1986, Scandinavian journal of work, environment & health.

[46]  K Victorin,et al.  Absence of mutagenic response to radiation from a video display terminal. , 1988, Scandinavian journal of work, environment & health.

[47]  A. Youk,et al.  Historical Cohort Study of US Man-Made Vitreous Fiber Production Workers: VI. Respiratory System Cancer Standardized Mortality Ratios Adjusted for the Confounding Effect of Cigarette Smoking , 2001, Journal of occupational and environmental medicine.

[48]  David M. Brown,et al.  A Comparison of Methods of Determining and Predicting the Pathogenicity of Mineral Fibers , 1996 .

[49]  J Dodgson,et al.  Updating lung cancer mortality among a cohort of man-made mineral fibre production workers in seven European countries. , 1986, Cancer letters.

[50]  L. R. Glass,et al.  Multiple-dose chronic inhalation toxicity study of size-separated kaolin refractory ceramic fiber in male Fischer 344 rats. , 1995, Inhalation toxicology.

[51]  G. Pigott,et al.  The effects of intrapleural injections of alumina and aluminosilicate (ceramic) fibres. , 1992, International journal of experimental pathology.

[52]  Peter S. J. Lees,et al.  End User Exposures to Man-Made Vitreous Fibers: I. Installation of Residential Insulation Products , 1993 .

[53]  T. Colby,et al.  Historical Cohort Study of US Man-Made Vitreous Fiber Production Workers: II. Mortality From Mesothelioma , 2001, Journal of occupational and environmental medicine.

[54]  M. Roller,et al.  Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats. , 1989, IARC scientific publications.

[55]  W. Moorman,et al.  Chronic Inhalation Toxicology of Fibrous Glass in Rats and Monkeys , 1988 .

[56]  L. W. Ortiz,et al.  Long-term health effects in hamsters and rats exposed chronically to man-made vitreous fibres. , 1987, The Annals of occupational hygiene.

[57]  Thomas J. Smith,et al.  Historical Cohort Study of US Man-Made Vitreous Fiber Production Workers: I. 1992 Fiberglass Cohort Follow-Up: Initial Findings , 2001, Journal of occupational and environmental medicine.

[58]  J. Olsen,et al.  Cancer incidence among European man-made vitreous fiber production workers. , 1999, Scandinavian journal of work, environment & health.

[59]  L. Maxim,et al.  A multiyear workplace-monitoring program for refractory ceramic fibers: findings and conclusions. , 1997, Regulatory toxicology and pharmacology : RTP.

[60]  P. Thévenaz,et al.  Studies on the inhalation toxicology of two fiberglasses and amosite asbestos in the Syrian golden hamster. Part II. Results of chronic exposure. , 1999, Inhalation toxicology.

[61]  R. Stone,et al.  Mortality among a cohort of US man-made mineral fiber workers: 1985 follow-up. , 1990, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[62]  P. Thévenaz,et al.  Studies on the inhalation toxicology of two fiberglasses and amosite asbestos in the syrian golden hamster. Part I. Results of a subchronic study and dose selection for a chronic study. , 1999, Inhalation toxicology.

[63]  J. Hadley,et al.  AIRBORNE GLASS FIBER CONCENTRATIONS DURING MANUFACTURING OPERATIONS INVOLVING GLASS WOOL INSULATION , 1993 .

[64]  M. R. Bailey,et al.  The long-term clearance kinetics of insoluble particles from the human lung. , 1982, The Annals of occupational hygiene.

[65]  P. Carthew,et al.  Intrapleural administration of vitreous high duty ceramic fibres and heated devitrified ceramic fibres does not give rise to pleural mesothelioma in rats , 1995, Human & experimental toxicology.

[66]  F. Pott.  Detection of mineral fibre carcinogenicity with the intraperitoneal test--recent results and their validity. , 1995, The Annals of occupational hygiene.

[67]  K. Donaldson,et al.  Influence of fibre length, dissolution and biopersistence on the production of mesothelioma in the rat peritoneal cavity. , 1999, The Annals of occupational hygiene.

[68]  J. Chang-Claude,et al.  Lung cancer mortality among European rock/slag wool workers: exposure-response analysis , 1998, Cancer Causes and Control.

[69]  L. Maxim,et al.  Risk analysis for mortality from respiratory tumors in a cohort of refractory ceramic fiber workers. , 2002, Regulatory toxicology and pharmacology : RTP.

[70]  V. Feron,et al.  Pulmonary response of hamsters to fibrous glass: chronic effects of repeated intratracheal instillation with or without benzo[a]pyrene. , 1985, Carcinogenesis.

[71]  D M Bernstein,et al.  Biopersistence of synthetic mineral fibers as a predictor of chronic intraperitoneal injection tumor response in rats. , 2001, Inhalation toxicology.

[72]  J. Chang-Claude,et al.  Cancer Mortality among Man‐Made Vitreous Fiber Production Workers , 1997, Epidemiology.

[73]  Torben Knudsen,et al.  High-alumina low-silica HT stone wool fibers: a chemical compositional range with high biosolubility. , 2002, Regulatory toxicology and pharmacology : RTP.

[74]  J Bignon,et al.  Mesotheliomas in rats following inoculation with acid-leached chrysotile asbestos and other mineral fibres. , 1981, Carcinogenesis.

[75]  G. Boorman,et al.  Concordance in diagnosis of mesotheliomas. , 1996, Toxicologic pathology.

[76]  C. P. Yu,et al.  Deposition of Inhaled Fibrous Particles in the Human Lung , 1988 .