Out of the cleanroom, self-assembled magnetic artificial cilia.

Micro-sized hair-like structures, such as cilia, are abundant in nature and have various functionalities. Many efforts have been made to mimic the fluid pumping function of cilia, but most of the fabrication processes for these "artificial cilia" are tedious and expensive, hindering their practical application. In this paper a cost-effective in situ fabrication technique for artificial cilia is demonstrated. The cilia are constructed by self-assembly of micron sized magnetic beads and encapsulated with soft polymer coatings. Actuation of the cilia induces an effective fluid flow, and the cilia lengths and distribution can be adjusted by varying the magnetic bead concentration and fabrication parameters.

[1]  S. Devasia,et al.  Characterization of mixing performance for bio-mimetic silicone cilia , 2010 .

[2]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[3]  Jaap M J den Toonder,et al.  Disaggregation of microparticle clusters by induced magnetic dipole-dipole repulsion near a surface. , 2013, Lab on a chip.

[4]  R. Superfine,et al.  Biomimetic cilia arrays generate simultaneous pumping and mixing regimes , 2010, Proceedings of the National Academy of Sciences.

[5]  J. Westerweel,et al.  Magnetically-actuated artificial cilia for microfluidic propulsion , 2009, 0901.3687.

[6]  D. Broer,et al.  Printed artificial cilia from liquid-crystal network actuators modularly driven by light. , 2009, Nature materials.

[7]  L. Mahadevan,et al.  Self-Organization of a Mesoscale Bristle into Ordered, Hierarchical Helical Assemblies , 2009, Science.

[8]  M. Vilfan,et al.  Self-assembled artificial cilia , 2010, Proceedings of the National Academy of Sciences.

[9]  E. Gaffney,et al.  Fluid mechanics of nodal flow due to embryonic primary cilia , 2008, Journal of The Royal Society Interface.

[10]  M. Prins,et al.  Magnetization and actuation of polymeric microstructures with magnetic nanoparticles for application in microfluidics , 2009 .

[11]  M. Prins,et al.  Micro-fluidic actuation using magnetic artificial cilia. , 2009, Lab on a chip.

[12]  S. Gorb,et al.  From micro to nano contacts in biological attachment devices , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  N. Hirokawa,et al.  Mechanism of Nodal Flow: A Conserved Symmetry Breaking Event in Left-Right Axis Determination , 2005, Cell.

[14]  Joanna Aizenberg,et al.  Bio‐inspired Design of Submerged Hydrogel‐Actuated Polymer Microstructures Operating in Response to pH , 2011, Advanced materials.

[15]  N. Heintz,et al.  To beat or not to beat: roles of cilia in development and disease. , 2003, Human molecular genetics.

[16]  J. Westerweel,et al.  Experimental investigation of the flow induced by artificial cilia. , 2011, Lab on a chip.

[17]  R Lloyd Carroll,et al.  Magnetically actuated nanorod arrays as biomimetic cilia. , 2007, Nano letters.

[18]  Lei Jiang,et al.  Bioinspired surfaces with special wettability. , 2005, Accounts of chemical research.

[19]  Dick Broer,et al.  Artificial cilia for active micro-fluidic mixing. , 2008, Lab on a chip.

[20]  Marcus L. Roper,et al.  Microscopic artificial swimmers , 2005, Nature.

[21]  Jaap M J den Toonder,et al.  Microfluidic manipulation with artificial/bioinspired cilia. , 2013, Trends in biotechnology.

[22]  Xuefeng Gao,et al.  Biophysics: Water-repellent legs of water striders , 2004, Nature.

[23]  Oswald Prucker,et al.  Artificial Cilia: Generation of Magnetic Actuators in Microfluidic Systems , 2011 .