PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress

[1]  J. Gutkind,et al.  Granulocyte Colony-stimulating Factor Induces Erk5 Activation, Which Is Differentially Regulated by Protein-tyrosine Kinases and Protein Kinase C , 2001, The Journal of Biological Chemistry.

[2]  E. Gelfand,et al.  MEKK2 Associates with the Adapter Protein Lad/RIBP and Regulates the MEK5-BMK1/ERK5 Pathway* , 2001, The Journal of Biological Chemistry.

[3]  J. Gutkind,et al.  Multiple Mitogen-Activated Protein Kinase Signaling Pathways Connect the Cot Oncoprotein to the c-junPromoter and to Cellular Transformation , 2000, Molecular and Cellular Biology.

[4]  R. Tapping,et al.  MEKK3 Directly Regulates MEK5 Activity as Part of the Big Mitogen-activated Protein Kinase 1 (BMK1) Signaling Pathway* , 1999, The Journal of Biological Chemistry.

[5]  E. Nishida,et al.  Activation of the Protein Kinase ERK5/BMK1 by Receptor Tyrosine Kinases , 1999, The Journal of Biological Chemistry.

[6]  W. Schaper,et al.  Okadaic acid and anisomycin are protective and stimulate the SAPK/JNK pathway. , 1999, Journal of cardiovascular pharmacology.

[7]  Shuang Huang,et al.  Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor , 1998, Nature.

[8]  Jiahuai Han,et al.  BMK1/ERK5 regulates serum‐induced early gene expression through transcription factor MEF2C , 1997, The EMBO journal.

[9]  M. Ishida,et al.  c-Src Is Required for Oxidative Stress-mediated Activation of Big Mitogen-activated Protein Kinase 1 (BMK1)* , 1997, The Journal of Biological Chemistry.

[10]  M. Cobb,et al.  Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms * , 1995, The Journal of Biological Chemistry.

[11]  Jiahuai Han,et al.  Primary structure of BMK1: a new mammalian map kinase. , 1995, Biochemical and biophysical research communications.

[12]  Gaochao Zhou,et al.  Components of a New Human Protein Kinase Signal Transduction Pathway (*) , 1995, The Journal of Biological Chemistry.

[13]  P. Cohen,et al.  Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines , 1995, Current Biology.

[14]  E. Krebs,et al.  Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells. , 1993, The Journal of biological chemistry.

[15]  P. Cohen,et al.  Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases , 1991, Nature.

[16]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.