A new formula for premature infants: effects on growth and nutritional status

Abstract Objective: Nutritional management influences immediate survival as well as subsequent growth and development of low birth weight and very low birth weight infants. Preterm infant formula (PTF) is used when there is an inadequate supply of mother’s milk or when the mother is unable to breastfeed and donor breast milk is unavailable. The purpose of this prospective multicenter study was to evaluate short-term effects on nutritional status (auxological and biochemical parameters) in a population of premature infants who received a preterm infant formula. Methods: Ninety-seven preterm infants with a birth weight between 500 g and 2000 g and a gestational age of 25–34 weeks postmenstrual age were randomly assigned to received a new preterm infant formula (Nutribèn Pre), and their nutritional status were compared to 75 fortified human milk (FHM) fed infants. Results: No significant differences were observed between FHM and Nutribèn Pre fed infants in terms of growth, feeding tolerance and biochemical profiles. Conclusion: Nutribèn Pre is a valid, effective and safe alternative for the nutrition of preterm infants.

[1]  J. Rigo,et al.  The nutrition of preterm infants. , 2012, Early human development.

[2]  Section On Breastfeeding,et al.  Breastfeeding and the Use of Human Milk , 2005, Pediatrics.

[3]  E. Bertino,et al.  Evaluation of postnatal growth of preterm infants , 2011, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[4]  W. McGuire,et al.  Promoting growth for preterm infants following hospital discharge , 2011, Archives of Disease in Childhood: Fetal and Neonatal Edition.

[5]  L. Corvaglia,et al.  Standard fortification of preterm human milk fails to meet recommended protein intake: Bedside evaluation by Near-Infrared-Reflectance-Analysis. , 2010, Early human development.

[6]  B. Poindexter,et al.  Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition , 2010, Journal of pediatric gastroenterology and nutrition.

[7]  R. Ehrenkranz,et al.  Nutritional Practices and Growth Velocity in the First Month of Life in Extremely Premature Infants , 2009, Pediatrics.

[8]  P. Iversen,et al.  Growth and nutrient intake among very-low-birth-weight infants fed fortified human milk during hospitalisation , 2009, British Journal of Nutrition.

[9]  B. Vohr,et al.  First-Week Protein and Energy Intakes Are Associated With 18-Month Developmental Outcomes in Extremely Low Birth Weight Infants , 2009, Pediatrics.

[10]  M. Kron,et al.  Intrauterine, Early Neonatal, and Postdischarge Growth and Neurodevelopmental Outcome at 5.4 Years in Extremely Preterm Infants After Intensive Neonatal Nutritional Support , 2009, Pediatrics.

[11]  T. Fahey,et al.  Nutrient-enriched formula versus standard term formula for preterm infants following hospital discharge. , 2016, The Cochrane database of systematic reviews.

[12]  J. Neu,et al.  Gastrointestinal development and meeting the nutritional needs of premature infants. , 2007, The American journal of clinical nutrition.

[13]  L. Wrage,et al.  Growth in the Neonatal Intensive Care Unit Influences Neurodevelopmental and Growth Outcomes of Extremely Low Birth Weight Infants , 2006, Pediatrics.

[14]  B. Koletzko,et al.  Nutrition of the Preterm Infant: Scientific Basis and Practical Guidelines , 2005 .

[15]  S. Looney,et al.  Prediction of Extrauterine Growth Retardation (EUGR) in VVLBW Infants , 2003, Journal of Perinatology.

[16]  E. Telemo,et al.  Breast-feeding, infant formulas, and the immune system. , 2003, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[17]  C. Klein.  Nutrient requirements for preterm infant formulas. , 2002, The Journal of nutrition.

[18]  W. Heird.  Determination of nutritional requirements in preterm infants, with special reference to 'catch-up' growth. , 2001, Seminars in neonatology : SN.

[19]  R. Cooke,et al.  Postnatal malnutrition and growth retardation: an inevitable consequence of current recommendations in preterm infants? , 2001, Pediatrics.

[20]  M. Picciano.  Nutrient composition of human milk. , 2001, Pediatric clinics of North America.

[21]  P. Sauer,et al.  Short-term growth and substrate use in very-low-birth-weight infants fed formulas with different energy contents. , 2000, The American journal of clinical nutrition.

[22]  C R Bauer,et al.  Longitudinal Growth of Hospitalized Very Low Birth Weight Infants , 1999, Pediatrics.

[23]  S Grantham-McGregor,et al.  A review of studies of the effect of severe malnutrition on mental development. , 1995, The Journal of nutrition.

[24]  B. Strupp,et al.  Malnutrition and the brain: changing concepts, changing concerns. , 1995, The Journal of nutrition.

[25]  J. Bitman,et al.  Comparison of the lipid composition of breast milk from mothers of term and preterm infants. , 1983, The American journal of clinical nutrition.

[26]  J. Lemons,et al.  Differences in the Composition of Preterm and Term Human Milk during Early Lactation , 1982, Pediatric Research.

[27]  S. Gross,et al.  Composition of breast milk from mothers of preterm infants. , 1981, Pediatrics.

[28]  N. Carter,et al.  A comparison of protein concentrations and energy in breast milk from preterm and term mothers. , 1981, Journal of human nutrition.

[29]  S. Atkinson,et al.  Energy and macronutrient content of human milk during early lactation from mothers giving birth prematurely and at term. , 1981, The American journal of clinical nutrition.