Platycodin D alleviates liver fibrosis and activation of hepatic stellate cells by regulating JNK/c-JUN signal pathway.

[1]  Po-Yuan Ke Diverse Functions of Autophagy in Liver Physiology and Liver Diseases , 2019, International journal of molecular sciences.

[2]  Guangchuan Wang,et al.  Carvedilol attenuates liver fibrosis by suppressing autophagy and promoting apoptosis in hepatic stellate cells. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[3]  Feng Zhang,et al.  Activation of autophagy is required for Oroxylin A to alleviate carbon tetrachloride‐induced liver fibrosis and hepatic stellate cell activation , 2018, International immunopharmacology.

[4]  Ja Hyun Koo,et al.  Gα12 overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells. , 2018, Journal of hepatology.

[5]  B. Liu,et al.  Platycodin D Inhibits Inflammatory Response in LPS-Stimulated Primary Rat Microglia Cells through Activating LXRα–ABCA1 Signaling Pathway , 2018, Front. Immunol..

[6]  C. Ho,et al.  The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling , 2018, Marine drugs.

[7]  Yifan Chen,et al.  Lipophagy and liver disease: New perspectives to better understanding and therapy. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[8]  V. Tsutsumi,et al.  Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways , 2017, World journal of gastroenterology.

[9]  L. Zhuo,et al.  Raf Kinase Inhibitory Protein Down-Expression Exacerbates Hepatic Fibrosis In Vivo and In Vitro , 2016, Cellular Physiology and Biochemistry.

[10]  Jeong-Seok Nam,et al.  TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition , 2016, Cellular Physiology and Biochemistry.

[11]  Muhammad Khan,et al.  Killing cancer with platycodin D through multiple mechanisms , 2015, Journal of cellular and molecular medicine.

[12]  D. Brenner,et al.  Recent advancement of molecular mechanisms of liver fibrosis , 2015, Journal of hepato-biliary-pancreatic sciences.

[13]  J. Wan,et al.  Macrophage autophagy protects against liver fibrosis in mice , 2015, Autophagy.

[14]  Y. Li,et al.  MAPK/JNK signalling: a potential autophagy regulation pathway , 2015, Bioscience reports.

[15]  P. Codogno,et al.  Autophagy: A Multifaceted Partner in Liver Fibrosis , 2014, BioMed research international.

[16]  Hongming Pan,et al.  p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. , 2014, Cancer letters.

[17]  Young Joon Lee,et al.  The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis , 2014, Evidence-based complementary and alternative medicine : eCAM.

[18]  Soon B. Hwang,et al.  Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication , 2013, Evidence-based complementary and alternative medicine : eCAM.

[19]  K. Faber,et al.  Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death. , 2013, Biochimica et biophysica acta.

[20]  M. Mi,et al.  Evaluation of the Spermicidal and Contraceptive Activity of Platycodin D, a Saponin from Platycodon grandiflorum , 2013, PloS one.

[21]  P. Jaisankar,et al.  Synergistic Apoptosis of CML Cells by Buthionine Sulfoximine and Hydroxychavicol Correlates with Activation of AIF and GSH-ROS-JNK-ERK-iNOS Pathway , 2013, PloS one.

[22]  M. Czaja,et al.  Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation , 2013, Cell Death and Differentiation.

[23]  Yeong Shik Kim,et al.  Platycodin D Inhibits Lipogenesis through AMPKα-PPARγ2 in 3T3-L1 Cells and Modulates Fat Accumulation in Obese Mice , 2012, Planta Medica.

[24]  L. An,et al.  Anti-atherosclerotic activity of platycodin D derived from roots of Platycodon grandiflorum in human endothelial cells. , 2012, Biological & pharmaceutical bulletin.

[25]  J. Daniluk,et al.  Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress , 2012, Journal of Gastroenterology.

[26]  S. Friedman,et al.  Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. , 2012, Gastroenterology.

[27]  M. Najimi,et al.  A role for autophagy during hepatic stellate cell activation. , 2012, Journal of hepatology.

[28]  G. Gores,et al.  Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. , 2011, Journal of hepatology.

[29]  P. Codogno,et al.  c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells. , 2009, Cancer research.

[30]  Hongxiang Sun,et al.  Platycodin D is a potent adjuvant of specific cellular and humoral immune responses against recombinant hepatitis B antigen. , 2009, Vaccine.

[31]  S. Friedman Hepatic fibrosis -- overview. , 2008, Toxicology.

[32]  F. Marra,et al.  Myofibroblast - like cells and liver fibrogenesis: Emerging concepts in a rapidly moving scenario. , 2008, Molecular aspects of medicine.

[33]  T. Wynn,et al.  Cellular and molecular mechanisms of fibrosis , 2008, The Journal of pathology.

[34]  Li‐jun Wu,et al.  Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. , 2008, Journal of pharmacological sciences.

[35]  G. Gores,et al.  Free Fatty Acids Induce JNK-dependent Hepatocyte Lipoapoptosis* , 2006, Journal of Biological Chemistry.

[36]  G. Gores,et al.  Activated stellate cells express the TRAIL receptor‐2/death receptor‐5 and undergo TRAIL‐mediated apoptosis , 2003, Hepatology.