Scalp recorded direct current brain potentials during human sleep

The direct current (DC) potential recorded from the scalp of awake humans has been considered a reflection of general changes in cortical excitability. This study examined DC potential shifts in humans during a night of continuous sleep. Standard polysomnographic recordings and skin temperature were measured simultaneously. Contrary to expectations, average DC potential level indicated higher negativity during nonrapid eye movement (NREM) sleep than REM sleep and wakefulness. Moreover, a dynamic regulation of the DC potential level was revealed in association with the NREM–REM sleep cycle comprising four successive phases: (i) a steep ‘NREM‐transition‐negative shift’ during the initial 10–15 min of the NREM sleep period; (ii) a more subtle ‘NREM‐positive slope’ during the subsequent NREM sleep period; (iii) a steep ‘REM‐transition‐positive shift’ starting shortly prior to the REM sleep period, and (iv) a ‘REM‐negative slope’, characterizing the remaining greater part of the REM sleep period. DC potential changes were only weakly related to changes in slow‐wave activity (r2 < 0.18). The NREM‐negative slope and REM‐positive slope could reflect, respectively, gradually increasing and decreasing cortical excitability resulting from widespread changes in the depolarization of apical dendrites. In contrast, the NREM‐transition‐negative shift and the REM‐transition‐positive shift may reflect the progression and retrogression, respectively, of a long‐lasting hyperpolarization in deeply lying neurons.

[1]  M. Steriade,et al.  A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[2]  P Achermann,et al.  Dynamics of EEG slow wave activity during physiological sleep and after administration of benzodiazepine hypnotics. , 1987, Human neurobiology.

[3]  G Buzsáki,et al.  The hippocampo-neocortical dialogue. , 1996, Cerebral cortex.

[4]  T. Marczynski,et al.  Neurochemical Interpretation of Cortical Slow Potentials as they Relate to Cognitive Processes and a Parsimonious Model of Mammalian Brain , 1993 .

[5]  P. Maquet,et al.  Sleep function(s) and cerebral metabolism , 1995, Behavioural Brain Research.

[6]  P. Achermann,et al.  Low-frequency (<1Hz) oscillations in the human sleep electroencephalogram , 1997, Neuroscience.

[7]  Pleydell-Pearce Cw,et al.  DC shifts and cognitive load. , 1995 .

[8]  J. Born,et al.  Effects of Early and Late Nocturnal Sleep on Declarative and Procedural Memory , 1997, Journal of Cognitive Neuroscience.

[9]  C W Pleydell-Pearce,et al.  DC shifts and cognitive load. , 1995, Electroencephalography and clinical neurophysiology. Supplement.

[10]  Slow potential shifts at sleep--wake transitions and shifts between NREM and REM sleep. , 1996, Sleep.

[11]  T. Sejnowski,et al.  Sleep and Memory , 2022 .

[12]  E J Speckmann,et al.  DC potentials of the cerebral cortex. Seizure activity and changes in gas pressures. , 1987, Reviews of physiology, biochemistry and pharmacology.

[13]  U. Mitzdorf Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena. , 1985, Physiological reviews.

[14]  C. Cipolli Sleep, Dreams and memory: an overview , 1995 .

[15]  S. Hillyard,et al.  Cephalic skin potentials in electroencephalography. , 1972, Electroencephalography and clinical neurophysiology.

[16]  D Contreras,et al.  Relations between cortical and thalamic cellular events during transition from sleep patterns to paroxysmal activity , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[17]  D. Contreras,et al.  Synchronization of fast (30-40 Hz) spontaneous cortical rhythms during brain activation , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[18]  J. Born,et al.  Spontaneous cortical slow-potential shifts and choice reaction time performance. , 1982, Electroencephalography and clinical neurophysiology.

[19]  Brigitte Rockstroh,et al.  Hyperventilation-induced EEG changes in humans and their modulation by an anticonvulsant drug , 1990, Epilepsy Research.

[20]  E. Wolpert A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. , 1969 .

[21]  I Feinberg,et al.  Systematic trends across the night in human sleep cycles. , 1979, Psychophysiology.

[22]  G. Rigdon,et al.  Generation of cortical event-related slow potentials in the rat involves nucleus basalis cholinergic innervation. , 1986, Electroencephalography and clinical neurophysiology.

[23]  S. Butler Methodological Issues in the Measurement of DC Biopotentials , 1993 .

[24]  J. Born,et al.  Effects of spontaneous cortical slow potentials on semantic information processing. , 1987, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[25]  W. Mccallum Human slow potential research: a review. , 1993 .

[26]  F Rösler,et al.  A correction method for DC drift artifacts. , 1993, Electroencephalography and clinical neurophysiology.

[27]  N. A. Aladzhalova Slow electrical processes in the brain , 1964 .

[28]  S. H. Curry,et al.  Slow Potential Changes in the Human Brain , 1993, NATO ASI Series.

[29]  M Steriade,et al.  Cholinergic and noradrenergic modulation of the slow (approximately 0.3 Hz) oscillation in neocortical cells. , 1993, Journal of neurophysiology.

[30]  O Vatter,et al.  [DC-potentials in the cerebral cortex]. , 1967, Die Naturwissenschaften.

[31]  R. Llinás,et al.  Coherent 40-Hz oscillation characterizes dream state in humans. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[32]  P. Davis,et al.  A SEARCH FOR CHANGES IN DIRECT-CURRENT POTENTIALS OF THE HEAD DURING SLEEP , 1939 .

[33]  J Kamiya,et al.  A very stable electrode system for recording human scalp potentials with direct-coupled amplifiers. , 1974, Electroencephalography and clinical neurophysiology.

[34]  Thomas Elbert,et al.  Threshold regulation - a key to the understanding of the combined dynamics of EEG and event-related potentials , 1987 .

[35]  M. Hirshkowitz,et al.  Polysomnography of Adults and Elderly: Sleep Architecture, Respiration, and Leg Movement , 1992, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[36]  M Haider,et al.  Event-related slow (DC) potentials in the human brain. , 1981, Reviews of physiology, biochemistry and pharmacology.

[37]  A. Nuñez,et al.  Unit activity of rat basal forebrain neurons: Relationship to cortical activity , 1996, Neuroscience.

[38]  E. Speckmann,et al.  Electrogenesis of Slow Potentials of the Brain , 1984 .

[39]  B. McNaughton,et al.  Reactivation of hippocampal ensemble memories during sleep. , 1994, Science.

[40]  B. Rockstroh,et al.  Slow potentials of the cerebral cortex and behavior. , 1990, Physiological reviews.

[41]  Thomas Elbert,et al.  SLOW CORTICAL POTENTIALS REFLECT THE REGULATION OF CORTICAL EXCITABILITY , 1993 .

[42]  A. Rechtschaffen,et al.  A manual of standardized terminology, technique and scoring system for sleep stages of human subjects , 1968 .

[43]  J. Born,et al.  Scalp recorded direct current potential shifts associated with the transition to sleep in man. , 1994, Electroencephalography and clinical neurophysiology.

[44]  G. Buzsáki,et al.  Selective activation of deep layer (V-VI) retrohippocampal cortical neurons during hippocampal sharp waves in the behaving rat , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[45]  H Bauer,et al.  Technical requirements for high-quality scalp DC recordings. , 1989, Electroencephalography and clinical neurophysiology.