An anisotropic viscous hyperelastic constitutive law for brain material finite-element modeling

Recent experimental studies have highlighted the significant influence of axonal fibers on the nonlinear and anisotropic behavior of brain tissue. This study aims to implement these properties in a transversely isotropic visco-hyperelastic constitutive law for brain tissue. The second step consists in implementation of this law under finite-element (FE) code to improve brain FE modeling by including brain tissue specificities proposed in the recent literature. Validation of the model is shown by comparison of numerical simulation of unconfined compression with experimental tests from the literature. This study represents a step toward more realistic brain FE modeling.Graphical Abstract

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