Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy.

Reactive oxygen species (ROS)-induced apoptosis is a widely practiced strategy for cancer therapy. Although photodynamic therapy (PDT) takes advantage of the spatial-temporal control of ROS generation, the meticulous participation of light, photosensitizer, and oxygen greatly hinders the broad application of PDT as a first-line cancer treatment option. An activatable system has been developed that enables tumor-specific singlet oxygen (1 O2 ) generation for cancer therapy, based on a Fenton-like reaction between linoleic acid hydroperoxide (LAHP) tethered on iron oxide nanoparticles (IO NPs) and the released iron(II) ions from IO NPs under acidic-pH condition. The IO-LAHP NPs are able to induce efficient apoptotic cancer cell death both in vitro and in vivo through tumor-specific 1 O2 generation and subsequent ROS mediated mechanism. This study demonstrates the effectiveness of modulating biochemical reactions as a ROS source to exert cancer death.

[1]  Liming Nie,et al.  Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy. , 2016, Chemical Society reviews.

[2]  Peng Huang,et al.  Overcoming the Achilles' heel of photodynamic therapy. , 2016, Chemical Society reviews.

[3]  Morteza Mahmoudi,et al.  Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues. , 2016, Nature nanotechnology.

[4]  W. Tan,et al.  A Smart Photosensitizer-Manganese Dioxide Nanosystem for Enhanced Photodynamic Therapy by Reducing Glutathione Levels in Cancer Cells. , 2016, Angewandte Chemie.

[5]  Chun-Wen Hsiao,et al.  An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy. , 2016, Journal of the American Chemical Society.

[6]  Kai Yang,et al.  Perfluorocarbon‐Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near‐Infrared Light to Enhance the Radiotherapy of Cancer , 2016, Advanced materials.

[7]  E. Akkaya,et al.  Remote-Controlled Release of Singlet Oxygen by the Plasmonic Heating of Endoperoxide-Modified Gold Nanorods: Towards a Paradigm Change in Photodynamic Therapy. , 2016, Angewandte Chemie.

[8]  E. Akkaya,et al.  A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light. , 2016, Angewandte Chemie.

[9]  Heliang Yao,et al.  Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction. , 2016, Angewandte Chemie.

[10]  B. Wilson,et al.  X-ray induced singlet oxygen generation by nanoparticle-photosensitizer conjugates for photodynamic therapy: determination of singlet oxygen quantum yield , 2016, Scientific Reports.

[11]  Chen-Sheng Yeh,et al.  Ultrasound-Induced Reactive Oxygen Species Mediated Therapy and Imaging Using a Fenton Reaction Activable Polymersome. , 2016, ACS nano.

[12]  G. Cosa,et al.  Reactive Oxygen Species Mediated Activation of a Dormant Singlet Oxygen Photosensitizer: From Autocatalytic Singlet Oxygen Amplification to Chemicontrolled Photodynamic Therapy. , 2016, Journal of the American Chemical Society.

[13]  Kaikai Wang,et al.  Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy , 2015, Nature Communications.

[14]  M. Eblan,et al.  Clinical Translation of Nanomedicine. , 2015, Chemical reviews.

[15]  Feng Liu,et al.  Nanoscintillator-mediated X-ray inducible photodynamic therapy for in vivo cancer treatment. , 2015, Nano letters.

[16]  P. Schumacker.  Reactive oxygen species in cancer: a dance with the devil. , 2015, Cancer cell.

[17]  Samuel Achilefu,et al.  Breaking the Depth Dependency of Phototherapy with Cerenkov Radiation and Low Radiance Responsive Nanophotosensitizers , 2015, Nature nanotechnology.

[18]  Zijian Guo,et al.  H2O2-activatable and O2-evolving nanoparticles for highly efficient and selective photodynamic therapy against hypoxic tumor cells. , 2015, Journal of the American Chemical Society.

[19]  K. Soo,et al.  Nanoparticles in photodynamic therapy. , 2015, Chemical reviews.

[20]  P. Schumacker,et al.  Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? , 2014, Nature Reviews Cancer.

[21]  Liang Cheng,et al.  Functional nanomaterials for phototherapies of cancer. , 2014, Chemical reviews.

[22]  Tsz-Leung To,et al.  Singlet oxygen Triplet Energy Transfer based imaging technology for mapping protein-protein proximity in intact cells , 2014, Nature Communications.

[23]  A. Wojtovich,et al.  Optogenetic control of ROS production , 2014, Redox biology.

[24]  S. Lukyanov,et al.  Genetically Encoded Immunophotosensitizer 4D5scFv-miniSOG is a Highly Selective Agent for Targeted Photokilling of Tumor Cells In Vitro , 2013, Theranostics.

[25]  Joe J. Harrison,et al.  Antimicrobial activity of metals: mechanisms, molecular targets and applications , 2013, Nature Reviews Microbiology.

[26]  C. Nathan,et al.  Beyond oxidative stress: an immunologist's guide to reactive oxygen species , 2013, Nature Reviews Immunology.

[27]  P. Ray,et al.  Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. , 2012, Cellular signalling.

[28]  David Kessel,et al.  Photodynamic therapy of cancer: An update , 2011, CA: a cancer journal for clinicians.

[29]  T. Mak,et al.  Regulation of cancer cell metabolism , 2011, Nature Reviews Cancer.

[30]  Peter R Ogilby,et al.  Singlet oxygen: there is indeed something new under the sun. , 2010, Chemical Society reviews.

[31]  Gang Zheng,et al.  Activatable photosensitizers for imaging and therapy. , 2010, Chemical reviews.

[32]  Peng Huang,et al.  Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? , 2009, Nature Reviews Drug Discovery.

[33]  N. Sharpless,et al.  ROS as a tumour suppressor? , 2006, Nature Cell Biology.

[34]  H. Saya,et al.  Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence , 2006, Nature Cell Biology.

[35]  Jinsong Liu,et al.  Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. , 2006, Cancer cell.

[36]  Michael R Hamblin,et al.  Photodynamic therapy and anti-tumour immunity , 2006, Nature Reviews Cancer.

[37]  Sayuri Miyamoto,et al.  Linoleic acid hydroperoxide reacts with hypochlorous acid, generating peroxyl radical intermediates and singlet molecular oxygen. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[38]  R. Gillies,et al.  Why do cancers have high aerobic glycolysis? , 2004, Nature Reviews Cancer.

[39]  Stanley B. Brown,et al.  The present and future role of photodynamic therapy in cancer treatment. , 2004, The Lancet. Oncology.

[40]  H. Hirt,et al.  Reactive oxygen species: metabolism, oxidative stress, and signal transduction. , 2004, Annual review of plant biology.

[41]  R. Jain,et al.  Photodynamic therapy for cancer , 2003, Nature Reviews Cancer.

[42]  P. Di Mascio,et al.  Singlet molecular oxygen generated from lipid hydroperoxides by the russell mechanism: studies using 18(O)-labeled linoleic acid hydroperoxide and monomol light emission measurements. , 2003, Journal of the American Chemical Society.

[43]  Mark von Zastrow,et al.  Signal transduction and endocytosis: close encounters of many kinds , 2002, Nature Reviews Molecular Cell Biology.