Acyclic analogs of pyrimidine nucleosides. Synthesis of 1-(2-hydroxyethoxymethyl)- and 1-(4-hydroxybutyl)-5-amino derivatives of uracil

[1]  R. Schinazi,et al.  Phenylselenenyl- and phenylthio-substituted pyrimidines as inhibitors of dihydrouracil dehydrogenase and uridine phosphorylase. , 1993, Journal of medicinal chemistry.

[2]  R T Walker,et al.  Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents. , 1992, Journal of medicinal chemistry.

[3]  R T Walker,et al.  A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine. , 1989, Journal of medicinal chemistry.

[4]  K. Yamada,et al.  A convenient synthesis of 9-(2-hydroxyethoxymethyl)guanine (acyclovir) and related compounds. , 1988, Chemical and pharmaceutical bulletin.

[5]  J. E. Kelsey,et al.  Effect of acyclic pyrimidines related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine on herpesviruses. , 1988, Journal of medicinal chemistry.

[6]  D. Sutton,et al.  Antiherpesvirus activity of 9-(4-hydroxy-3-hydroxy-methylbut-1-yl)guanine (BRL 39123) in cell culture , 1987, Antimicrobial Agents and Chemotherapy.

[7]  K. Park,et al.  Inhibition of uridine phosphorylase from Escherichia coli by benzylacyclouridines. , 1986, Biochemical pharmacology.

[8]  T. Lin,et al.  Synthesis of 1-[[2-hydroxy-1-(hydroxymethyl)ethoxy] methyl]-5-benzyluracil and its amino analogue, new potent uridine phosphorylase inhibitors with high water solubility. , 1985, Journal of medicinal chemistry.

[9]  D. Nelson,et al.  Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[10]  P. Calabresi,et al.  Potentiation of 5-fluoro-2'-deoxyuridine antineoplastic activity by the uridine phosphorylase inhibitors benzylacyclouridine and benzyloxybenzylacyclouridine. , 1984, Cancer research.

[11]  C. Crumpacker,et al.  Effects of the nucleoside analog 2'-nor-2'-deoxyguanosine on human cytomegalovirus replication , 1984, Antimicrobial Agents and Chemotherapy.

[12]  S. Chu,et al.  Synthesis of pyrimidine acyclonucleosides , 1981 .

[13]  D. J. Bauer,et al.  9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group , 1978, Nature.

[14]  H. Schaeffer,et al.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[15]  G. Jackson,et al.  Nonclassical Antimetabolites XXIII: Simulation of 5′-Phosphoribosyl Binding VI. Relative Contribution of the Oxygen Functions of the 2′-Deoxy-5′-phosphoribosyl Moiety of 2′-Deoxyuridylate to Thymidylate Synthetase , 1965 .

[16]  A. P. Phillips Some 5-Substituted Aminouracils , 1951 .