Phase contrast imaging using a micro focus x-ray source

Phase contrast x-ray imaging, a new technique to increase the imaging contrast for the tissues with close attenuation coefficients, has been studied since mid 1990s. This technique reveals the possibility to show the clear details of the soft tissues and tumors in small scale resolution. A compact and low cost phase contrast imaging system using a conventional x-ray source is described in this paper. Using the conventional x-ray source is of great importance, because it provides the possibility to use the method in hospitals and clinical offices. Simple materials and components are used in the setup to keep the cost in a reasonable and affordable range.Tungsten Kα1 line with the photon energy 59.3 keV was used for imaging. Some of the system design details are discussed. The method that was used to stabilize the system is introduced. A chicken thigh bone tissue sample was used for imaging followed by the image quality, image acquisition time and the potential clinical application discussion. High energy x-ray beam can be used in phase contrast imaging. Therefore the radiation dose to the patients can be greatly decreased compared to the traditional x-ray radiography.

[1]  R. Fleming,et al.  Asymmetrically cut crystals as optical elements for highly collimated x‐ray beams , 1995 .

[2]  Daniel Fogarty,et al.  In‐laboratory diffraction‐enhanced X‐ray imaging for articular cartilage , 2010, Clinical anatomy.

[3]  E. Pisano,et al.  Diffraction enhanced x-ray imaging. , 1997, Physics in medicine and biology.

[4]  Jun Li,et al.  A computed tomography implementation of multiple-image radiography. , 2006, Medical physics.

[5]  N. Galatsanos,et al.  Multiple-image radiography. , 2003, Physics in medicine and biology.

[6]  K. Nugent,et al.  Quantitative Phase Imaging Using Hard X Rays. , 1996, Physical review letters.

[7]  Carolyn A. MacDonald,et al.  Molybdenum microfocus source coupling to polycapillary optics for powder diffraction , 2002, SPIE Optics + Photonics.

[8]  Dean Chapman,et al.  The design and application of an in-laboratory diffraction-enhanced x-ray imaging instrument. , 2009, The Review of scientific instruments.

[9]  Dan Stutman,et al.  Talbot phase-contrast x-ray imaging for the small joints of the hand , 2011, Physics in medicine and biology.

[10]  F. Pfeiffer,et al.  X-ray tomography using the full complex index of refraction , 2012, Physics in medicine and biology.

[11]  Application of absorption and refraction matching techniques for diffraction enhanced imaging , 2002 .

[12]  M. Krause,et al.  Natural widths of atomic K and L levels, Kα X‐ray lines and several KLL Auger lines , 1979 .

[13]  S. Wilkins,et al.  Phase-contrast imaging of weakly absorbing materials using hard X-rays , 1995, Nature.

[14]  Jun Li,et al.  Multiple‐image radiography for human soft tissue , 2006, Journal of anatomy.

[15]  Zhong Zhong,et al.  Design and implementation of a compact low-dose diffraction enhanced medical imaging system. , 2009, Academic radiology.