Cholinergic mechanisms in Tourette syndrome

To examine the role of the cholinergic system in Tourette syndrome, we administered intramuscular physostigmine and scopolamine hydrobromide to 10 patients, evaluating both motor tics and involuntary vocalizations. Patients showed a consistent abatement of motor tics and exacerbation of vocal tics after scopolamine injection. The scopolamine effect was reversed by physostigmine. These data suggest that the cholinergic system plays a role in the pharmacologic patho-physiology of Tourette syndrome. The pharmacology of vocal and motor tics may differ, and cholinergic manipulation may benefit some patients.

[1]  R. Baldessarini,et al.  Pathophysiologic basis of tardive dyskinesia. , 1977, Advances in biochemical psychopharmacology.

[2]  H. Klawans.  The pharmacology of extrapyramidal movement disorders. , 1972, Monographs in neural sciences.

[3]  S. Siegel,et al.  Nonparametric Statistics for the Behavioral Sciences , 2022, The SAGE Encyclopedia of Research Design.

[4]  S. Stahl,et al.  Physostigmine in Gilles de la Tourette's syndrome. , 1980, The New England journal of medicine.

[5]  A. Barbeau.  Cholinergic treatment in the Tourette syndrome. , 1980, The New England journal of medicine.

[6]  R. Bruun,et al.  Gilles de la Tourette's syndrome: summary of clinical experience with 250 patients and suggested nomenclature for tic syndromes. , 1976, Advances in neurology.