Longitudinal Changes in BMD and Bone Geometry in a Population‐Based Study

We prospectively examined vBMD and structural bone parameters assessed by QCT among participants of the InCHIANTI study over a 6‐yr follow‐up. Periosteal apposition occurred both in men and women. Endocortical resorption causes bone loss in older women despite periosteal apposition.

[1]  P. Kannus,et al.  Peripheral Quantitative Computed Tomography in Human Long Bones: Evaluation of In Vitro and In Vivo Precision , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[2]  R. Heaney,et al.  Bone Dimensional Change with Age: Interactions of Genetic, Hormonal, and Body Size Variables , 1997, Osteoporosis International.

[3]  U. Koch,et al.  Bone-muscle strength indices for the human lower leg. , 2000, Bone.

[4]  P. Delmas,et al.  Bone quality--the material and structural basis of bone strength and fragility. , 2006, The New England journal of medicine.

[5]  E. Barrett-Connor,et al.  Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. , 2001, JAMA.

[6]  M. Bouxsein,et al.  Age-related differences in cross-sectional geometry of the forearm bones in healthy women , 1994, Calcified Tissue International.

[7]  Sundeep Khosla,et al.  Population‐Based Study of Age and Sex Differences in Bone Volumetric Density, Size, Geometry, and Structure at Different Skeletal Sites , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[8]  S. Bandinelli,et al.  Correlates of bone quality in older persons. , 2006, Bone.

[9]  F B Hu,et al.  Comparison of population-averaged and subject-specific approaches for analyzing repeated binary outcomes. , 1998, American journal of epidemiology.

[10]  C. Thomas,et al.  Relation between age, femoral neck cortical stability, and hip fracture risk , 2005, The Lancet.

[11]  S. Bandinelli,et al.  Structural adaptations to bone loss in aging men and women. , 2006, Bone.

[12]  Luigi Ferrucci,et al.  Subsystems Contributing to the Decline in Ability to Walk: Bridging the Gap Between Epidemiology and Geriatric Practice in the InCHIANTI Study , 2000, Journal of the American Geriatrics Society.

[13]  Ray Fleming,et al.  NIH Consensus Panel Addresses Osteoporosis Prevention, Diagnosis, and Therapy , 2000 .

[14]  O. Johnell,et al.  Bone loss and bone size after menopause. , 2003, The New England journal of medicine.

[15]  Susan R. Johnson,et al.  Osteoporosis prevention, diagnosis, and therapy. , 2001, JAMA.

[16]  J. M. Guralnik,et al.  Aging bone in men and women: beyond changes in bone mineral density , 2003, Osteoporosis International.

[17]  W C Hayes,et al.  Subperiosteal expansion and cortical remodeling of the human femur and tibia with aging. , 1982, Science.

[18]  N. Day,et al.  Validity and repeatability of the EPIC-Norfolk Physical Activity Questionnaire. , 2002, International journal of epidemiology.

[19]  Christopher H. Morrell,et al.  Accelerated Longitudinal Decline of Aerobic Capacity in Healthy Older Adults , 2005, Circulation.

[20]  F Berrino,et al.  Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. , 1997, International journal of epidemiology.

[21]  Ego Seeman,et al.  Bone Fragility: Failure of Periosteal Apposition to Compensate for Increased Endocortical Resorption in Postmenopausal Women , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[22]  E. Seeman.  The periosteum—a surface for all seasons , 2007, Osteoporosis International.

[23]  S. Adami,et al.  Radial Bending Breaking Resistance Derived by Densitometric Evaluation Predicts Femoral Neck Fracture , 2001, Osteoporosis International.