The successes and failures of physiologically based pharmacokinetic modeling: there is room for improvement
暂无分享,去创建一个
[1] L. Berezhkovskiy,et al. Determination of volume of distribution at steady state with complete consideration of the kinetics of protein and tissue binding in linear pharmacokinetics. , 2004, Journal of pharmaceutical sciences.
[2] Wilhelm Huisinga,et al. Lumping of physiologically-based pharmacokinetic models and a mechanistic derivation of classical compartmental models , 2010, Journal of Pharmacokinetics and Pharmacodynamics.
[3] Grant R. Wilkinson,et al. A physiological approach to hepatic drug clearance , 1975 .
[4] Amin Rostami-Hodjegan,et al. Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice , 2011, Paediatric anaesthesia.
[5] Jin Y. Jin,et al. A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer , 2013, Biopharmaceutics & drug disposition.
[6] Patrick Poulin,et al. Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution. , 2002, Journal of pharmaceutical sciences.
[7] L Zhang,et al. Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review , 2011, Clinical pharmacology and therapeutics.
[8] Malcolm Rowland,et al. Rodgers T, Rowland M. 2006. Physiologically‐based Pharmacokinetic Modeling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. J Pharm Sci 95:1238–1257. , 2007 .
[9] Anette Müllertz,et al. In vitro models for the prediction of in vivo performance of oral dosage forms. , 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[10] Amin Rostami-Hodjegan,et al. Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay! , 2012, Biopharmaceutics & drug disposition.
[11] Malcolm Rowland,et al. Clearance concepts in pharmacokinetics , 1973, Journal of Pharmacokinetics and Biopharmaceutics.
[12] M. Rowland,et al. Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions. , 2006, Journal of pharmaceutical sciences.
[13] M Jamei,et al. ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport‐Mediated PK and DDIs in Humans , 2013, Clinical pharmacology and therapeutics.
[14] K Rowland-Yeo,et al. Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development , 2013, CPT: pharmacometrics & systems pharmacology.
[15] Hong Sun,et al. Effects of renal failure on drug transport and metabolism. , 2006, Pharmacology & therapeutics.
[16] G. Tucker,et al. A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance , 2010, Clinical pharmacokinetics.
[17] Houston Jb,et al. Prediction of Human Pharmacokinetics in 2013 and Beyond , 2013 .
[18] Malcolm Rowland,et al. Physiologically-based pharmacokinetics in drug development and regulatory science. , 2011, Annual review of pharmacology and toxicology.
[19] Malcolm Rowland,et al. PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach. , 2011, Journal of pharmaceutical sciences.
[20] J Brian Houston,et al. Prediction of Human Pharmacokinetics in 2013 and Beyond , 2013, Drug Metabolism and Disposition.
[21] Leslie Z Benet,et al. Lead PK commentary: predicting human pharmacokinetics. , 2011, Journal of pharmaceutical sciences.
[22] A. Vinks,et al. The Future of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure in Pregnant Women , 2013, CPT: pharmacometrics & systems pharmacology.
[23] Shiew-Mei Huang,et al. The utility of modeling and simulation in drug development and regulatory review. , 2013, Journal of pharmaceutical sciences.