Particle flow control by induced dipolar interaction of superparamagnetic microbeads

Magnetic particles diluted in liquid agglomerate in rod-like particle arrays if an external homogeneous magnetic field is applied. This work introduces a method to specifically exploit particle–particle interaction to obtain flow control of magnetic particles without changing the motion state of the carrier liquid. Experiments show the possibility to uncouple the particle flux from the motion state of liquid. We show how this method may be applied to design a microfluidic geometry in which the particle flow in a specific direction is either enabled or suppressed by the relative orientation of the fluid velocity and the external field.

[1]  Mwj Menno Prins,et al.  Multibody interactions of actuated magnetic particles used as fluid drivers in microchannels , 2010 .

[2]  J. Friend,et al.  Fabrication of microfluidic devices using polydimethylsiloxane. , 2010, Biomicrofluidics.

[3]  Camelia Albon,et al.  Tunneling magnetoresistance sensors for high resolutive particle detection , 2009 .

[4]  Marc D. Porter,et al.  Magnetic particle diverter in an integrated microfluidic format , 2005 .

[5]  D. Beebe,et al.  Three-dimensional micro-channel fabrication in polydimethylsiloxane (PDMS) elastomer , 2000, Journal of Microelectromechanical Systems.

[6]  T. Park,et al.  Effective mixing in a microfluidic chip using magnetic particles. , 2009, Lab on a chip.

[7]  Mark A. Hayes,et al.  Active Control of Dynamic Supraparticle Structures in Microchannels , 2001 .

[8]  D W M Marr,et al.  In situ assembly of linked geometrically coupled microdevices , 2008, Proceedings of the National Academy of Sciences.

[9]  Claude Fermon,et al.  Toward a magnetoresistive chip cytometer: Integrated detection of magnetic beads flowing at cm/s velocities in microfluidic channels , 2009 .

[10]  Nicole Pamme,et al.  Magnetism and microfluidics. , 2006, Lab on a chip.

[11]  Martin A. M. Gijs,et al.  Magnetic beads retention device for sandwich immunoassay: comparison of off-chip and on-chip antibody incubation , 2009 .

[12]  Martin A. M. Gijs,et al.  Magnetic bead handling on-chip: new opportunities for analytical applications , 2004 .

[13]  Mikkel Fougt Hansen,et al.  Theoretical comparison of magnetic and hydrodynamic interactions between magnetically tagged particles in microfluidic systems , 2005 .

[14]  O. Hansen,et al.  Magnetic separation in microfluidic systems using microfabricated electromagnets—experiments and simulations , 2005 .

[15]  G. Fonnum,et al.  Characterisation of Dynabeads® by magnetization measurements and Mössbauer spectroscopy , 2005 .

[16]  Andreas Hütten,et al.  A hydrodynamic switch: Microfluidic separation system for magnetic beads , 2009 .

[17]  A. Hütten,et al.  Magnetic ratchet for biotechnological applications , 2009 .