Immunoglobulin‐producing cells in human pericancerous lymph nodes

Immunoglobulin‐producing cells and their synthesized immunoglobulins were studied by immunofluorescent techniques in 30 human pericancerous lymph nodes and 13 lymph nodes from control subjects. The production of immunoglobulins was found to be strongest in histologically active lymph nodes; however, some lymph nodes rich in follicles contained no immuno‐globulin‐producing cells. The amount of immunoglobulins produced appears to have no relation to the presence or absence of metastatic cells in the lymph nodes—the cells with immunoglobulins are not usually in contact with the cancer cells. The predominance of immunoglobulin A in pericancerous nodes is important because antibodies of this type do not fix the complement and are not likely to be cytotoxic. The immunoglobulins thus synthesized can react against cancer cells or the products of cellular metabolism. This last hypothesis seems most probable.

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