Saturable First‐Pass Kinetics of Propranolol

Reduced bioavailability (F) due to hepatic first‐pass extraction of an oral dose (D) is a well‐known pharmacokinetic phenomenon. An integrated solution for Michaelis‐Menten kinetics of the first‐pass effect is derived from the maximal metabolic rate (Vm), volume of distribution (Vd), first order absorption rate constant (ka), Michaelis constant (Km), and liver blood flow (Q).

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