Theory and practice of ubiquitous quantitative chemical analysis using conventional computer optical disk drives.

We demonstrate a new attractive approach for ubiquitous quantitative chemical or biological sensing when analog signals are acquired from conventional optical disk drives, and these signals are used for quantitative detection of optical changes of sensing films deposited on conventional CD and DVD optical disks. Our developed analytical model of the operation of this Lab-on-DVD system describes the optical response of sensing films deposited onto the read surface of optical disks by taking into account the practical aspects of system performance that include possible reagent leaching effects, water sampling (delivering) efficiency, and possible changes of the film morphology after water removal. By applying a screen-printing process, we demonstrated a laboratory-scale automated production of sensing films with an average thickness of approximately 10 microm and a thickness relative standard deviation of <3% across multiple films. Finally, we developed a system for delivery of water-sample volumes to sensing films on the disk that utilized a multifunctional jewel case assembly.

[1]  Christian Igel,et al.  Cross-reactive metal ion sensor array in a micro titer plate format. , 2003, Analytical chemistry.

[2]  Radislav A. Potyrailo,et al.  Analytical instrumentation infrastructure for combinatorial and high-throughput development of formulated discrete and gradient polymeric sensor materials arrays , 2005 .

[3]  Marc Madou,et al.  Lab on a CD. , 2006, Annual review of biomedical engineering.

[4]  Ernö Pretsch,et al.  Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 1. General Characteristics. , 1997, Chemical reviews.

[5]  James J La Clair,et al.  Molecular screening on a compact disc. , 2003, Organic & biomolecular chemistry.

[6]  Radislav A Potyrailo,et al.  Analog signal acquisition from computer optical disk drives for quantitative chemical sensing. , 2006, Analytical chemistry.

[7]  F. Ricci,et al.  Prussian Blue based screen printed biosensors with improved characteristics of long-term lifetime and pH stability. , 2003, Biosensors & bioelectronics.

[8]  Radislav A. Potyrailo,et al.  Morpho butterfly wing scales demonstrate highly selective vapour response , 2007 .

[9]  H. Girault,et al.  Antioxidant redox sensors based on DNA modified carbon screen-printed electrodes. , 2006, Analytical chemistry.

[10]  Radislav A Potyrailo,et al.  Polymeric sensor materials: toward an alliance of combinatorial and rational design tools? , 2006, Angewandte Chemie.

[11]  S. Saavedra,et al.  Dye leaching from a doped sol–gel is eliminated by conjugation to a dendrimer , 2001 .

[12]  Günter Roth,et al.  Measuring biomolecular binding events with a compact disc player device. , 2005, Angewandte Chemie.

[13]  G. V. Rosmalen,et al.  Confocal compact scanning optical microscope based on compact disc technology. , 1991, Applied optics.

[14]  D. Beebe,et al.  Microfluidic tectonics platform: A colorimetric, disposable botulinum toxin enzyme‐linked immunosorbent assay system , 2004, Electrophoresis.

[15]  Anthony Turner,et al.  On the use of screen- and ink-jet printing to produce amperometric enzyme electrodes for lactate☆ , 1996 .

[16]  Aleksandra Lobnik,et al.  pH optical sensors based on sol–gels: Chemical doping versus covalent immobilization , 1998 .

[17]  Loïc J Blum,et al.  Diazonium-protein adducts for graphite electrode microarrays modification: direct and addressed electrochemical immobilization. , 2005, Journal of the American Chemical Society.

[18]  Franco Quercioli,et al.  MONITORING OF AN ATOMIC FORCE MICROSCOPE CANTILEVER WITH A COMPACT DISK PICKUP , 1999 .

[19]  B. Limoges,et al.  BIOTINYLATION OF SCREEN-PRINTED CARBON ELECTRODES THROUGH THE ELECTROCHEMICAL REDUCTION OF THE DIAZONIUM SALT OF P-AMINOBENZOYL BIOCYTIN , 1999 .

[20]  O. Wolfbeis.  Fiber-optic chemical sensors and biosensors. , 2000, Analytical chemistry.

[21]  Ashok Mulchandani,et al.  V-type nerve agent detection using a carbon nanotube-based amperometric enzyme electrode. , 2006, Analytical chemistry.

[22]  Radislav A. Potyrailo.  Fiber optic and portable instruments for ammonia sensing in field operating conditions , 1993, Other Conferences.

[23]  Kenneth S Suslick,et al.  A colorimetric sensor array for organics in water. , 2005, Journal of the American Chemical Society.

[24]  N. Lawrence,et al.  Voltammetric characterization of a N,N'-diphenyl-p-phenylenediamine-loaded screen-printed electrode: a disposable sensor for hydrogen sulfide. , 2003, Analytical chemistry.

[25]  Chih-Liang Chu,et al.  Development of an Optical Accelerometer with a DVD Pick-up Head , 2005 .

[26]  R. A. Potyrailo,et al.  Selective gas nanosensors with multisize CdSe nanocrystal/polymer composite films and dynamic pattern recognition , 2006 .

[27]  M. Mcshane,et al.  Core-referenced ratiometric fluorescent potassium ion sensors using self-assembled ultrathin films on europium nanoparticles , 2005, IEEE Sensors Journal.

[28]  H. H. Hopkins.  Diffraction theory of laser read-out systems for optical video discs , 1979 .

[29]  Kuang-Chao Fan,et al.  DESIGN NOTE: The development of a low-cost focusing probe for profile measurement , 2000 .

[30]  B. Cunningham,et al.  A label-free optical technique for detecting small molecule interactions. , 2002, Biosensors & bioelectronics.

[31]  Shannon E. Stitzel,et al.  Cross-reactive chemical sensor arrays. , 2000, Chemical reviews.