Decreased “natural killer” effect in tumor‐bearing mice and its relation to the immunity against oncorna virus‐determined cell surface antigens

In comparison to control animals the natural killer (NK) efficiency of spleen and blood lymphocyte population was reduced in three systems of tumor‐bearing animals: transplanted methylcholanthrene (MC) and primary Moloney sarcoma virus (MSV) induced sarcomas in CBA mice, and athymic “nude” mice carrying grafts of human lymphoblastoid cell lines. No evidence for suppressor cells was found. After regression of the MSV tumors the activity was high again. The effect was measured on YAC ‐ a culture line of a Moloney leukemia virus‐induced lymphoma in an A mouse ‐ which is highly sensitive to the NK effect.

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