Shear as a mechanism for sonically induced biological effects.
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By controlled irradiation of erythrocyte suspensions at 20 kHz it is demonstrated that shear associated with acoustic microstreaming can be an important mechanism for biological effects of sound. Two effective sources of acoustic microstreaming are stable oscillating gas bubbles and transversely oscillating wires. The threshold displacement amplitude for achieving critical shear can be reduced by increasing the solvent viscosity and reducing the radius of the source of acoustic streaming. The threshold stress was found to decrease by 55% or more when the sample was heated to 45°C or higher for 10 min. This suggests that synergism exists between mechanical and thermal mechanisms for sonic effects. Mass transfer associated with small‐scale acoustic streaming controls the rate of cell disruption.