Simulation of cholinesterase status at different scenarios of nerve agent exposure.

[1]  B. Lukey,et al.  Toxicokinetics of nerve agents. , 2008 .

[2]  Timothy C. Marrs,et al.  Chemical warfare agents , 2007 .

[3]  P. Eyer,et al.  Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds. , 2006, Biochemical pharmacology.

[4]  P. Eyer,et al.  Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model. , 2005, Toxicology and applied pharmacology.

[5]  P. Eyer,et al.  Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes. , 2004, Biochemical pharmacology.

[6]  D. Jovanović Pharmacokinetics of pralidoxime chloride , 1989, Archives of Toxicology.

[7]  H. Benschop,et al.  Toxicokinetics of the nerve agent (+/-)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration. , 2003, Toxicology and applied pharmacology.

[8]  P. Eyer The Role of Oximes in the Management of Organophosphorus Pesticide Poisoning , 2003, Toxicological reviews.

[9]  P. Eyer,et al.  Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates , 2002, Archives of Toxicology.

[10]  H. Benschop,et al.  Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs. , 2000, Toxicology and applied pharmacology.

[11]  J. Romano,et al.  Chemical Warfare Agents : Toxicity at Low Levels , 2000 .

[12]  P. Taylor,et al.  Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis. , 2000, Biochemistry.

[13]  M. Nagao,et al.  Definitive evidence for the acute sarin poisoning diagnosis in the Tokyo subway. , 1997, Toxicology and applied pharmacology.

[14]  David R Franz,et al.  Medical Aspects of Chemical and Biological Warfare , 1997 .

[15]  N. Ariel,et al.  Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre. , 1996, The Biochemical journal.

[16]  P. Taylor,et al.  Structural bases for the specificity of cholinesterase catalysis and inhibition. , 1995, Toxicology letters.

[17]  D. Bailey,et al.  The acetylcholinesterase oxime reactivator HI‐6 in man: Pharmacokinetics and tolerability in combination with atropine , 1995, Biopharmaceutics & drug disposition.

[18]  R. Dawson,et al.  Review of oximes available for treatment of nerve agent poisoning , 1994, Journal of applied toxicology : JAT.

[19]  Baggot Jd Application of interspecies scaling to the bispyridinium oxime HI-6. , 1994 .

[20]  F. R. Parker,et al.  Effect of pyridostigmine bromide on acceleration tolerance and performance. , 1994, Aviation, space, and environmental medicine.

[21]  M. Quigley,et al.  Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat. , 1993, Aviation, space, and environmental medicine.

[22]  B. Ballantyne,et al.  Clinical and Experimental Toxicology of Organophosphates and Carbamates , 1992 .

[23]  T. Marrs,et al.  52 – Efficacy, toxicity and clinical use of oximes in anticholinesterase poisoning , 1992 .

[24]  A. Hansen,et al.  Comparison of several oximes against poisoning by soman, tabun and GF. , 1992, Toxicology.

[25]  D. R. Anderson,et al.  Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning in rodents. , 1992, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[26]  J R Keeler,et al.  Pyridostigmine used as a nerve agent pretreatment under wartime conditions. , 1991, JAMA.

[27]  P. H. Wang,et al.  Kinetic studies and structure-activity relationships of bispyridinium oximes as reactivators of acetylcholinesterase inhibited by organophosphorus compounds. , 1986, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[28]  R. H. Inns,et al.  Treatment of poisoning by soman , 1985 .

[29]  S. Taylor,et al.  Primary structures of the catalytic subunits from two molecular forms of acetylcholinesterase. A comparison of NH2-terminal and active center sequences. , 1985, The Journal of biological chemistry.

[30]  F. Fonnum,et al.  A method for generating toxic vapors of soman: toxicity of soman by inhalation in rats. , 1985, Toxicology and applied pharmacology.

[31]  U. Maier,et al.  Pyridostigmine kinetics in healthy subjects and patients with myasthenia gravis , 1985, Clinical pharmacology and therapeutics.

[32]  R. H. Inns,et al.  The efficacy of bispyridinium derivatives in the treatment of organophosphonate poisoning in the guinea‐pig , 1983, The Journal of pharmacy and pharmacology.

[33]  A. Green A theoretical kinetic analysis of the protective action exerted by eserine and other carbamate anticholinesterases against poisoning by organophosphorus compounds. , 1983, Biochemical pharmacology.

[34]  J. Lipp,et al.  comparison of the efficacy of HS-6 versus HI-6 when combined with atropine, pyridostigmine and clonazepam for soman poisoning in the monkey. , 1980, Archives internationales de pharmacodynamie et de therapie.

[35]  E. Reiner,et al.  Spontaneous reactivation and aging of dimethylphosphorylated acetylcholinesterase and cholinesterase , 1973 .

[36]  F. Sidell,et al.  Toxogonin and pralidoxime: kinetic comparison after intravenous administration to man. , 1972, Journal of pharmaceutical sciences.

[37]  E. Reiner,et al.  Enzyme inhibitors as substrates : interactions of esterases with esters of organophosphorus and carbamic acids , 1972 .

[38]  F. Sidell,et al.  Intramuscular and intravenous administration of small doses of 2-pyridinium aldoxime methochloride to man. , 1971, Journal of pharmaceutical sciences.

[39]  F. Sidell,et al.  Toxogonin: blood levels and side effects after intramuscular administration in man. , 1970, Journal of pharmaceutical sciences.

[40]  D. R. Davies,et al.  The use of carbamates and atropine in the protection of animals against poisoning by 1,2,2-trimethylpropyl methylphosphonofluoridate. , 1970, Biochemical pharmacology.

[41]  A. L. Green,et al.  The reactivation of cholinesterase inhibited with organophosphorus compounds. 2. Reactivation by pyridinealdoxime methiodides. , 1958, The Biochemical journal.