Proaccelerin Levels in Leukemias.

The behavior of factor V activity (proaccelerin) was investigated in 94 patients with acute and chronic leukemia. In acute myeloblastic and chronic myeloid leukemia normal or low levels of factor V were usually found. On the contrary in acute lymphoblastic and chronic lymphocytic leukemia normal or high levels were frequently observed. In ten patients (4 cases with acute myeloblastic leukemia,S cases with chronic myeloid leukemia and 1 case with acute lymphoblastic leukemia) there were markedly decreased levels of proaccelerin (less than 40 %). In two patients with acute promyelocytic leukemia normal or elevated factor V activity was found. The significance of these variations in proaccelerin levels observed in leukemia is discussed.

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