论文信息 - Concise and stereoselective synthesis of enamides and dienamides by a titanium-mediated coupling method.

Concise and stereoselective synthesis of enamides and dienamides by a titanium-mediated coupling method.

Ynamide-titanium alkoxide complexes underwent hydrolysis or addition to aldehydes and ketones to give single, stereodefined di- or trisubstituted enamides in good yields. Alternatively, coupling of a variety of alkyne-titanium alkoxide complexes with terminal ynamides generated amino-substituted titanacyclopentadienes, hydrolysis or aldehyde addition of which afforded stereodefined dienamides. [reaction--see text]

Shuji Hirano | R. Tanaka | F. Sato | H. Urabe

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