A family-based association study of PLP1 and schizophrenia

Recently, proteolipid protein 1 (PLP1) has been identified as downregulated in schizophrenia by quantitative PCR and other technologies. In this work we attempted to investigate the role of PLP1 in the etiology of schizophrenia using a family based association study in 487 Chinese Han family trios. The TDT for allelic association demonstrated that, in male, a weak association was detected in SNP rs475827 with p=0.0294, suggesting that the genetic polymorphisms within PLP1 in male are likely to confer an increased susceptibility to schizophrenia in the Chinese population.

[1]  S. Strakowski,et al.  Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. , 2002, Bipolar disorders.

[2]  E. Bertini,et al.  Schwann cell expression of PLP1 but not DM20 is necessary to prevent neuropathy , 2003, Annals of neurology.

[3]  C. ZAPATA,et al.  Sampling variance and distribution of the D′ measure of overall gametic disequilibrium between multiallelic loci , 2001, Annals of human genetics.

[4]  I. Gottesman,et al.  At issue: genes, experience, and chance in schizophrenia--positioning for the 21st century. , 1997, Schizophrenia bulletin.

[5]  D. Curtis,et al.  An extended transmission/disequilibrium test (TDT) for multi‐allele marker loci , 1995, Annals of human genetics.

[6]  P. Keck,et al.  Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. , 2001, American journal of medical genetics.

[7]  J. Trojanowski,et al.  Recent advances in defining the neuropathology of schizophrenia , 1996, Acta Neuropathologica.

[8]  G. Feng,et al.  Family-based association study of DTNBP1 in 6p22.3 and schizophrenia , 2003, Molecular Psychiatry.

[9]  B. Dastugue,et al.  Genotype–phenotype correlation in inherited brain myelination defects due to proteolipid protein gene mutations , 2000, European Journal of Human Genetics.

[10]  S. Faraone,et al.  The genetics of schizophrenia , 1999, Current psychiatry reports.

[11]  S. Malcolm,et al.  The proteolipid protein gene and myelin disorders in man and animal models , 2000 .

[12]  F. Benes,et al.  Emerging principles of altered neural circuitry in schizophrenia , 2000, Brain Research Reviews.

[13]  I. Griffiths,et al.  Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene , 2004, Acta Neuropathologica.

[14]  K. Kendler,et al.  The genetics of schizophrenia: a current, genetic-epidemiologic perspective. , 1993, Schizophrenia bulletin.

[15]  Xinping Yang,et al.  Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1 , 2001, Nature Genetics.

[16]  M. Karayiorgou,et al.  A Turning Point in Schizophrenia Genetics , 1997, Neuron.

[17]  S. Germer,et al.  High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR. , 2000, Genome research.

[18]  B. Popko,et al.  Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions , 2002, The Journal of cell biology.

[19]  D. Housman,et al.  Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes , 2000, Molecular Psychiatry.

[20]  M J Owen,et al.  Searching for schizophrenia genes. , 2001, Trends in molecular medicine.

[21]  Peter B. Jones,et al.  Oligodendrocyte dysfunction in schizophrenia and bipolar disorder , 2003, The Lancet.

[22]  Erik A Sistermans,et al.  Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation. , 2002, Brain : a journal of neurology.

[23]  N. Uranova,et al.  Electron microscopy of oligodendroglia in severe mental illness , 2001, Brain Research Bulletin.

[24]  W. Ewens,et al.  Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). , 1993, American journal of human genetics.

[25]  Alessandro Bertolino,et al.  Regionally Specific Neuronal Pathology in Untreated Patients with Schizophrenia: A Proton Magnetic Resonance Spectroscopic Imaging Study , 1998, Biological Psychiatry.

[26]  Paul J. Harrison.  The neuropathology of schizophrenia , 2008 .

[27]  I. Day,et al.  An efficient procedure for genotyping single nucleotide polymorphisms. , 2001, Nucleic acids research.

[28]  P. McGuffin,et al.  Linkage and associated studies of schizophrenia. , 2000, American journal of medical genetics.