Formation of bubbles in a multisection flow-focusing junction.

The formation of bubbles in a flow-focusing (FF) junction comprising multiple rectangular sections is described. The simplest junctions comprise two sections (throat and orifice). Systematic investigation of the influence on the formation of bubbles of the flow of liquid and the geometry of the junction identifies regimes that generate monodisperse, bidisperse, and tridisperse trains of bubbles. The mechanisms by which these junctions form monodisperse and bidisperse bubbles are inferred from the shapes of the gas thread during breakup: these mechanisms differ primarily by the process in which the gas thread collapses in the throat and/or orifice. The dynamic self-assembly of bidisperse bubbles leads to unexpected groupings of bubbles during their flow along the outlet channel.

[1]  George M. Whitesides,et al.  An Axisymmetric Flow‐Focusing Microfluidic Device , 2005 .

[2]  A. deMello,et al.  Quantitative detection of protein expression in single cells using droplet microfluidics. , 2007, Chemical communications.

[3]  Helen Song,et al.  Reactions in droplets in microfluidic channels. , 2006, Angewandte Chemie.

[4]  Minseok Seo,et al.  Microfluidic consecutive flow-focusing droplet generators. , 2007, Soft matter.

[5]  M. V. Dyke,et al.  An Album of Fluid Motion , 1982 .

[6]  G. Whitesides,et al.  Flowing lattices of bubbles as tunable, self-assembled diffraction gratings. , 2006, Small.

[7]  Toru Torii,et al.  Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[8]  George M. Whitesides,et al.  Coding/Decoding and Reversibility of Droplet Trains in Microfluidic Networks , 2007, Science.

[9]  O. Urakawa,et al.  Small - , 2007 .

[10]  H. Stone,et al.  Formation of dispersions using “flow focusing” in microchannels , 2003 .

[11]  David A. Weitz,et al.  A new device for the generation of microbubbles , 2004 .

[12]  A. Gañán-Calvo,et al.  Perfectly monodisperse microbubbling by capillary flow focusing. , 2001, Physical review letters.

[13]  G. Whitesides,et al.  Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up. , 2006, Lab on a chip.

[14]  Mitsutoshi Nakajima,et al.  The generation of highly monodisperse droplets through the breakup of hydrodynamically focused microthread in a microfluidic device , 2004 .

[15]  George M. Whitesides,et al.  Interfacial instabilities in a microfluidic Hele-Shaw cell. , 2008, Soft matter.

[16]  George M. Whitesides,et al.  Formation of monodisperse bubbles in a microfluidic flow-focusing device , 2004 .

[17]  Piotr Garstecki,et al.  Formation of bubbles and droplets in parallel, coupled flow-focusing geometries. , 2008, Small.

[18]  S. Quake,et al.  Dynamic pattern formation in a vesicle-generating microfluidic device. , 2001, Physical review letters.

[19]  D. Weitz,et al.  Geometrically mediated breakup of drops in microfluidic devices. , 2003, Physical review letters.

[20]  Liang-Yin Chu,et al.  Designer emulsions using microfluidics , 2008 .

[21]  Clayton J. Radke,et al.  The motion of long bubbles in polygonal capillaries. Part 2. Drag, fluid pressure and fluid flow , 1995, Journal of Fluid Mechanics.

[22]  G. Whitesides,et al.  Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). , 1998, Analytical chemistry.

[23]  Yanwei Jia,et al.  Control and measurement of the phase behavior of aqueous solutions using microfluidics. , 2007, Journal of the American Chemical Society.

[24]  Helen Song,et al.  Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the capillary numbers , 2003 .

[25]  Phonons in a one-dimensional microfluidic crystal , 2006, 1008.1155.

[26]  Samuel K Sia,et al.  Mixing with bubbles: a practical technology for use with portable microfluidic devices. , 2006, Lab on a chip.

[27]  G. Whitesides,et al.  Generation of monodisperse particles by using microfluidics: control over size, shape, and composition. , 2005, Angewandte Chemie.

[28]  D. Weitz,et al.  Monodisperse Double Emulsions Generated from a Microcapillary Device , 2005, Science.

[29]  N. Gershenfeld,et al.  Microfluidic Bubble Logic , 2006, Science.

[30]  Piotr Garstecki,et al.  Synthesis of composite emulsions and complex foams with the use of microfluidic flow-focusing devices. , 2007, Small.

[31]  G. Whitesides,et al.  Oscillations with uniquely long periods in a microfluidic bubble generator , 2005 .

[32]  Toshiro Higuchi,et al.  Droplet formation in a microchannel network. , 2002, Lab on a chip.