PRIMARY EBV INFECTION AND HEMATOLOGICAL FINDINGS IN TURKISH CHILDREN: A RETROSPECTIVE, SINGLE-CENTER STUDY

Abstract Aim: Primary infection with EBV during childhood is usually asymptomatic. Hematologic abnormalities such as hemolytic anemia, thrombocytopenia, and neutropenia are relatively common, but aplastic anemia, severe thrombocytopenia, severe neutropenia, and lymphoid malignancies are rare. In this retrospective study, we have analyzed data from children with primary EBV infection who were examined at our center over 12 years to describe the distribution, clinical features, complications, and outcome of EBV in Turkish children. Materials and Methods: Data from all children (age

[1]  C. Selmi,et al.  The clinical implications of selective IgA deficiency , 2019, Journal of translational autoimmunity.

[2]  C. Andersen,et al.  Epstein-Barr virus and its association with disease - a review of relevance to general practice , 2019, BMC Family Practice.

[3]  R. Marsh Epstein–Barr Virus and Hemophagocytic Lymphohistiocytosis , 2018, Front. Immunol..

[4]  C. Díaz-Pedroche,et al.  [Hemophagocytic lymphohistiocytosis: Analysis of 18 cases]. , 2016, Medicina clinica.

[5]  S. Karaman,et al.  Cervical lymphadenopathies in children: A prospective clinical cohort study. , 2016, International journal of pediatric otorhinolaryngology.

[6]  G. Khan,et al.  Global burden of deaths from Epstein-Barr virus attributable malignancies 1990-2010 , 2014, Infectious Agents and Cancer.

[7]  T. Holmøy,et al.  Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation , 2012, Viruses.

[8]  P. Hanley,et al.  Hodgkin Disease and the Role of the Immune System , 2011, Pediatric hematology and oncology.

[9]  İ. Reisli,et al.  Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: ‘Similarities and differences’ , 2010, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[10]  A. Karaman,et al.  The ongoing problem with peripheral lymphadenopathies: which ones are malignant? , 2010, Pediatric Surgery International.

[11]  Feneli Karachaliou,et al.  Herpes virus antibodies seroprevalence in children with autoimmune thyroid disease , 2008, Endocrine.

[12]  R. Khanna,et al.  Epstein–Barr virus‐associated Hodgkin's lymphoma , 2004, British journal of haematology.

[13]  Kwok-Hung Chan,et al.  Epstein-Barr virus-associated infectious mononucleosis in Chinese children , 2003, The Pediatric infectious disease journal.

[14]  H. Jenson Acute complications of Epstein-Barr virus infectious mononucleosis , 2000, Current opinion in pediatrics.

[15]  K. Ohshima,et al.  Clinicopathological findings of virus‐associated hemophagocytic syndrome in bone marrow: Association with Epstein‐Barr virus and apoptosis , 1999, Pathology international.

[16]  L. Dewitt,et al.  Neurologic complications of infectious mononucleosis. , 1994, Pediatric neurology.

[17]  R. Chang,et al.  A prospective study of primary Epstein-Barr virus infections among university students in Hong Kong. , 1990, The American journal of tropical medicine and hygiene.

[18]  S. Halstead,et al.  Incidence of infectious mononucleosis at the Universities of California and Hawaii. , 1979, The Journal of infectious diseases.

[19]  R. Biggar,et al.  Primary epstein‐barr virus infections in African infants. II. Clinical and serological observations during seroconversion , 1978, International journal of cancer.

[20]  W. Henle,et al.  Observations on childhood infections with the Epstein-Barr virus. , 1970, The Journal of infectious diseases.

[21]  M. Kanlıkama,et al.  Predictive factors for malignancy in patients with persistent cervical lymphadenopathy , 2015, European Archives of Oto-Rhino-Laryngology.

[22]  S. Kaneko,et al.  Graves' disease associated with infectious mononucleosis due to primary Epstein-Barr virus infection: report of 3 cases. , 2010, Internal medicine.

[23]  J. Meier,et al.  Epstein-Barr Virus Infections: Biology, Pathogenesis, and Management , 1993, Annals of Internal Medicine.