Amyloid –β pathology in Alzheimer’s disease: A nano delivery approach
暂无分享,去创建一个
[1] D. V. Gowda,et al. Development and Evaluation of Solid Lipid Nanoparticles for the Clearance of Aβ in Alzheimer’s Disease , 2023, Pharmaceutics.
[2] A. John,et al. Bilosomes as a Potential Carrier to Enhance Cognitive Effects of Bacopa monnieri Extract on Oral Administration , 2022, Journal of Health and Allied Sciences NU.
[3] D. Bloom,et al. Global and regional projections of the economic burden of Alzheimer's disease and related dementias from 2019 to 2050: A value of statistical life approach , 2022, EClinicalMedicine.
[4] Merhan E. Ali,et al. A Brain-Targeted Approach to Ameliorate Memory Disorders in a Sporadic Alzheimer’s Disease Mouse Model via Intranasal Luteolin-Loaded Nanobilosomes , 2022, Pharmaceutics.
[5] H. Abbas,et al. The Tragedy of Alzheimer’s Disease: Towards Better Management via Resveratrol-Loaded Oral Bilosomes , 2021, Pharmaceutics.
[6] Meenakshi Singh,et al. A systematic review of carbohydrate-based bioactive molecules for Alzheimer's disease. , 2021, Future medicinal chemistry.
[7] R. Taliyan,et al. Solid Lipid Nanoparticles (SLNs): An Advanced Drug Delivery System Targeting Brain through BBB , 2021, Pharmaceutics.
[8] Tae-Eun Park,et al. Recent advances with liposomes as drug carriers for treatment of neurodegenerative diseases , 2021, Biomedical Engineering Letters.
[9] B. Dunn,et al. Approval of Aducanumab for Alzheimer Disease-the FDA's Perspective. , 2021, JAMA internal medicine.
[10] Yanan Liu,et al. Multifunctional Selenium Quantum Dots for the Treatment of Alzheimer's Disease by Reducing Aβ-Neurotoxicity and Oxidative Stress and Alleviate Neuroinflammation. , 2021, ACS applied materials & interfaces.
[11] Weiwei He,et al. Emerging Nanotechnology for Treatment of Alzheimer’s and Parkinson’s Disease , 2021, Frontiers in Bioengineering and Biotechnology.
[12] C. Li,et al. Biomimetic Dendrimer–Peptide Conjugates for Early Multi‐Target Therapy of Alzheimer's Disease by Inflammatory Microenvironment Modulation , 2021, Advanced materials.
[13] A. Atri,et al. Aducanumab produced a clinically meaningful benefit in association with amyloid lowering , 2021, Alzheimer's Research & Therapy.
[14] M. Abbas. Potential Role of Nanoparticles in Treating the Accumulation of Amyloid-Beta Peptide in Alzheimer’s Patients , 2021, Polymers.
[15] P. Kamla,et al. Nanocarriers for Alzheimer’s disease: Research and patent update , 2021 .
[16] M. Narayan,et al. Carbon Quantum Dots for Treatment of Amyloid Disorders. , 2021, ACS applied nano materials.
[17] Anjali Sharma,et al. Dendrimer-tesaglitazar conjugate induces a phenotype shift of microglia and enhances β-amyloid phagocytosis. , 2020, Nanoscale.
[18] D. Holtzman,et al. Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol , 2020, Proceedings of the National Academy of Sciences.
[19] T. Davis,et al. Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders , 2020, Frontiers in Physiology.
[20] A. Šarić,et al. Identification of on- and off-pathway oligomers in amyloid fibril formation , 2020, Chemical science.
[21] Ya-ru Huang,et al. The Toxicity and Polymorphism of β-Amyloid Oligomers , 2020, International journal of molecular sciences.
[22] T. P. Davis,et al. Amyloidosis: Mitigation of Amyloidosis with Nanomaterials (Adv. Mater. 18/2020) , 2020 .
[23] Tiziano Tuccinardi,et al. The History of Nanoscience and Nanotechnology: From Chemical–Physical Applications to Nanomedicine , 2019, Molecules.
[24] R. Morishita,et al. Novel Method for Rapid Assessment of Cognitive Impairment Using High-Performance Eye-Tracking Technology , 2019, Scientific Reports.
[25] M. Sakharkar,et al. Benefits of curcumin in brain disorders , 2019, BioFactors.
[26] A. Colell,et al. Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress , 2019, Redox biology.
[27] Samantha Donnellan,et al. Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis , 2019, Journal of Interdisciplinary Nanomedicine.
[28] M. Wolfe. Structure and Function of the γ-Secretase Complex. , 2019, Biochemistry.
[29] F. Sobott,et al. Native Ion Mobility-Mass Spectrometry reveals the formation of β-barrel shaped Amyloid-β hexamers in a membrane-mimicking environment. , 2019, Journal of the American Chemical Society.
[30] F. Maxfield,et al. Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils , 2019, bioRxiv.
[31] Seungpyo Hong,et al. Diagnosis of Alzheimer’s disease utilizing amyloid and tau as fluid biomarkers , 2019, Experimental & Molecular Medicine.
[32] J. Cladera,et al. Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection. , 2019, Nanomedicine : nanotechnology, biology, and medicine.
[33] T. Hyeon,et al. Magnetite/Ceria Nanoparticle Assemblies for Extracorporeal Cleansing of Amyloid‐β in Alzheimer's Disease , 2019, Advanced materials.
[34] Chan Beum Park,et al. Multifunctional carbon dots as a therapeutic nanoagent for modulating Cu(ii)-mediated β-amyloid aggregation. , 2019, Nanoscale.
[35] D. Michaelson,et al. ApoE4: an emerging therapeutic target for Alzheimer’s disease , 2019, BMC Medicine.
[36] Alzheimer's Association∗. 2019 Alzheimer's disease facts and figures , 2019, Alzheimer's & Dementia.
[37] M. T. Caccamo,et al. Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine , 2019, Journal of Nanomaterials.
[38] W. Ray,et al. The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease , 2019, Front. Aging Neurosci..
[39] Hui Li,et al. The Role of NMDA Receptors in Alzheimer’s Disease , 2019, Front. Neurosci..
[40] T. P. Davis,et al. Nucleation of β-rich oligomers and β-barrels in the early aggregation of human islet amyloid polypeptide. , 2019, Biochimica et biophysica acta. Molecular basis of disease.
[41] Yilin Wang,et al. Effects of Gold Nanospheres and Nanocubes on Amyloid-β Peptide Fibrillation. , 2019, Langmuir : the ACS journal of surfaces and colloids.
[42] Z. Bian,et al. Review of Current Strategies for Delivering Alzheimer’s Disease Drugs across the Blood-Brain Barrier , 2019, International journal of molecular sciences.
[43] G. Phillips,et al. Dendrimeric Poly(Epsilon-Lysine) Delivery Systems for the Enhanced Permeability of Flurbiprofen across the Blood-Brain Barrier in Alzheimer’s Disease , 2018, International journal of molecular sciences.
[44] Z. Bozsó,et al. Structural Optimization of Foldamer-Dendrimer Conjugates as Multivalent Agents against the Toxic Effects of Amyloid Beta Oligomers , 2018, Molecules.
[45] C. Ho,et al. In vitro neuroprotective effects of naringenin nanoemulsion against β-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation. , 2018, International journal of biological macromolecules.
[46] K. Ting,et al. Current development of biodegradable polymeric materials for biomedical applications , 2018, Drug design, development and therapy.
[47] E. Mufson,et al. Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease , 2018, Neurobiology of Disease.
[48] J. Herms,et al. BACE1 Inhibitor MK-8931 Alters Formation but Not Stability of Dendritic Spines , 2018, Front. Aging Neurosci..
[49] J. Udgaonkar,et al. Structural mechanisms of oligomer and amyloid fibril formation by the prion protein. , 2018, Chemical communications.
[50] Yin Luo,et al. Exploring the Mechanism of Inhibition of Au Nanoparticles on the Aggregation of Amyloid-β(16-22) Peptides at the Atom Level by All-Atom Molecular Dynamics , 2018, International journal of molecular sciences.
[51] J. Christie. Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the Early Diagnosis of Dementia Across a Variety of Healthcare Settings , 2018, Issues in mental health nursing.
[52] T. Loftsson,et al. Solubility of Cyclodextrins and Drug/Cyclodextrin Complexes , 2018, Molecules.
[53] Michael K Danquah,et al. Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations , 2018, Beilstein journal of nanotechnology.
[54] H. Kalbitzer,et al. Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptides. , 2018, Chemical communications.
[55] A. Silva,et al. Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization , 2018, Journal of Nanobiotechnology.
[56] C. Lyketsos,et al. Use of FDA approved medications for Alzheimer's disease in mild dementia is associated with reduced informal costs of care , 2018, International Psychogeriatrics.
[57] K. Nilsson,et al. Amyloid fibril polymorphism: a challenge for molecular imaging and therapy , 2018, Journal of internal medicine.
[58] G. Landreth,et al. Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease , 2018, Journal of Neuroinflammation.
[59] M. Foley,et al. Aminopyrimidine Class Aggregation Inhibitor Effectively Blocks Aβ-Fibrinogen Interaction and Aβ-Induced Contact System Activation. , 2018, Biochemistry.
[60] Hong Zhang,et al. Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease. , 2018, ACS nano.
[61] H. Scheraga,et al. Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain , 2018, Proceedings of the National Academy of Sciences.
[62] Xueji Zhang,et al. Synergistic Inhibitory Effect of GQDs-Tramiprosate Covalent Binding on Amyloid Aggregation. , 2018, ACS chemical neuroscience.
[63] X. Jing,et al. Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer’s disease , 2018, Drug delivery.
[64] D. Choi,et al. Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer’s disease , 2018, Drug delivery.
[65] Xufeng Zhu,et al. Sulfur Nanoparticles with Novel Morphologies Coupled with Brain-Targeting Peptides RVG as a New Type of Inhibitor Against Metal-Induced Aβ Aggregation. , 2017, ACS chemical neuroscience.
[66] K. Pandima Devi,et al. Phytol-loaded PLGA nanoparticle as a modulator of Alzheimer’s toxic Aβ peptide aggregation and fibrillation associated with impaired neuronal cell function , 2017, Artificial cells, nanomedicine, and biotechnology.
[67] A. Saleh,et al. Applications of nanoparticle systems in drug delivery technology , 2017, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.
[68] A. Camins,et al. Review of the advances in treatment for Alzheimer disease: Strategies for combating β-amyloid protein. , 2018, Neurologia.
[69] P. Yip,et al. Detection of cognitive impairment using self-rated AD8 and informant-reported AD8. , 2018, Journal of the Formosan Medical Association = Taiwan yi zhi.
[70] J. Kuźnicki,et al. Knockdown of amyloid precursor protein increases calcium levels in the endoplasmic reticulum , 2017, Scientific Reports.
[71] Xu Chen,et al. Chiral penicillamine-modified selenium nanoparticles enantioselectively inhibit metal-induced amyloid β aggregation for treating Alzheimer's disease. , 2017, Journal of colloid and interface science.
[72] E. Giralt,et al. Peptide multifunctionalized gold nanorods decrease toxicity of β-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease. , 2017, Nanomedicine : nanotechnology, biology, and medicine.
[73] Yu-jiong Wang,et al. PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering Aβ generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice , 2017, Oncotarget.
[74] C. Jack,et al. Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers , 2017, The Lancet Neurology.
[75] S. Réhman,et al. Enhanced neuroprotection of anthocyanin-loaded PEG-gold nanoparticles against Aβ1-42-induced neuroinflammation and neurodegeneration via the NF-KB /JNK/GSK3β signaling pathway. , 2017, Nanomedicine : nanotechnology, biology, and medicine.
[76] Ping Zhou,et al. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer A&bgr; Peptides , 2017, Circulation research.
[77] M. Cascella,et al. The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer’s disease: an overview of pre-clinical studies and translational perspectives in clinical practice , 2017, Infectious Agents and Cancer.
[78] C. Jack,et al. A phase 3 trial of IV immunoglobulin for Alzheimer disease , 2017, Neurology.
[79] Y. Kuo,et al. Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin , 2017, International journal of nanomedicine.
[80] K. Seppi,et al. Magnetic resonance imaging for the diagnosis of Parkinson’s disease , 2017, Journal of Neural Transmission.
[81] Taolei Sun,et al. The size-effect of gold nanoparticles and nanoclusters in the inhibition of amyloid-β fibrillation. , 2017, Nanoscale.
[82] T. Deller,et al. Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms , 2017, Front. Mol. Neurosci..
[83] J. Herz,et al. Functional Roles of the Interaction of APP and Lipoprotein Receptors , 2017, Front. Mol. Neurosci..
[84] K. Black,et al. Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes , 2017, Cellular and Molecular Life Sciences.
[85] A. Neves,et al. Resveratrol and Grape Extract-loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s Disease , 2017, Molecules.
[86] Deepti Goyal,et al. Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer's Disease. , 2017, ACS combinatorial science.
[87] A. Jong,et al. Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine , 2017, Scientific Reports.
[88] P. Reddy,et al. Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer's disease Neurons. , 2017, Journal of Alzheimer's disease : JAD.
[89] Norelle C. Wildburger,et al. Soluble Amyloid-beta Aggregates from Human Alzheimer’s Disease Brains , 2016, Scientific Reports.
[90] L. Fenart,et al. Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases , 2016, Molecules.
[91] E. Tao,et al. Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability. , 2016, Biomaterials.
[92] D. B. Vieira,et al. Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier , 2016, International journal of nanomedicine.
[93] M. Gairí,et al. Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments , 2016, Proceedings of the National Academy of Sciences.
[94] Yan Zhou,et al. Cerebral Blood Flow Alterations as Assessed by 3D ASL in Cognitive Impairment in Patients with Subcortical Vascular Cognitive Impairment: A Marker for Disease Severity , 2016, Front. Aging Neurosci..
[95] W. Cerpa,et al. Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies , 2016, Neural plasticity.
[96] Raquel Ferreira,et al. Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases. , 2016, Journal of controlled release : official journal of the Controlled Release Society.
[97] Bin-bo Jiang,et al. HP-β-cyclodextrin as an inhibitor of amyloid-β aggregation and toxicity. , 2016, Physical chemistry chemical physics : PCCP.
[98] H. Soares,et al. The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers , 2016, The Journal of Pharmacology and Experimental Therapeutics.
[99] H. Soares,et al. Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects , 2016, The Journal of Pharmacology and Experimental Therapeutics.
[100] C. Fardella,et al. Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension , 2016, International journal of molecular sciences.
[101] D. Hill,et al. Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials , 2016, Alzheimer's Research & Therapy.
[102] Mehrdad Hamidi,et al. Cubosomes: remarkable drug delivery potential. , 2016, Drug discovery today.
[103] Michele Vendruscolo,et al. Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation , 2016, Nature Communications.
[104] E. Liu,et al. First-In-Human safety and long-term exposure data for AAB-003 (PF-05236812) and biomarkers after intravenous infusions of escalating doses in patients with mild to moderate Alzheimer’s disease , 2016, Alzheimer's Research & Therapy.
[105] Wei-Jen Tang. Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus , 2016, Trends in Endocrinology & Metabolism.
[106] Barbara Ruozi,et al. Nanoparticle transport across the blood brain barrier , 2016, Tissue barriers.
[107] E. Liu,et al. Vanutide Cridificar (ACC-001) and QS-21 Adjuvant in Individuals with Early Alzheimer's Disease: Amyloid Imaging Positron Emission Tomography and Safety Results from a Phase 2 Study. , 2016, The journal of prevention of Alzheimer's disease.
[108] D. Holtzman,et al. Impaired Autophagy in APOE4 Astrocytes. , 2016, Journal of Alzheimer's disease : JAD.
[109] J. L. Santos,et al. Control of polymeric nanoparticle size to improve therapeutic delivery. , 2015, Journal of controlled release : official journal of the Controlled Release Society.
[110] S. Kile,et al. IVIG treatment of mild cognitive impairment due to Alzheimer's disease: a randomised double-blinded exploratory study of the effect on brain atrophy, cognition and conversion to dementia , 2015, Journal of Neurology, Neurosurgery & Psychiatry.
[111] O. Abdallah,et al. Novel piperine-loaded Tween-integrated monoolein cubosomes as brain-targeted oral nanomedicine in Alzheimer’s disease: pharmaceutical, biological, and toxicological studies , 2015, International journal of nanomedicine.
[112] N. Raz,et al. Appraising the Role of Iron in Brain Aging and Cognition: Promises and Limitations of MRI Methods , 2015, Neuropsychology Review.
[113] S. An,et al. Role of apolipoprotein E in neurodegenerative diseases , 2015, Neuropsychiatric disease and treatment.
[114] G. Baillie,et al. The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease , 2015, Future science OA.
[115] R. Riek,et al. Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation , 2015, Scientific Reports.
[116] R. Daneman,et al. The blood-brain barrier. , 2015, Cold Spring Harbor perspectives in biology.
[117] Prakash Khadka,et al. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability , 2014 .
[118] Laixiang Lin,et al. Feasibility of β-Sheet Breaker Peptide-H102 Treatment for Alzheimer's Disease Based on β-Amyloid Hypothesis , 2014, PloS one.
[119] M. Masserini,et al. Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease. , 2014, Nanomedicine : nanotechnology, biology, and medicine.
[120] Youfu Wang,et al. Carbon quantum dots: synthesis, properties and applications , 2014 .
[121] Jurgen A. H. R. Claassen,et al. β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease , 2014, Front. Aging Neurosci..
[122] Viney Lather,et al. Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues , 2014, Journal of pharmacy & bioallied sciences.
[123] A. Chacko,et al. Pathways for Small Molecule Delivery to the Central Nervous System Across the Blood-Brain Barrier , 2014, Perspectives in medicinal chemistry.
[124] Charles Duyckaerts,et al. Multifunctional nanoliposomes with curcumin-lipid derivative and brain targeting functionality with potential applications for Alzheimer disease. , 2014, European journal of medicinal chemistry.
[125] G. Bu,et al. The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease , 2014, Front. Aging Neurosci..
[126] Anton P. J. Middelberg,et al. Towards designer nanoemulsions for precision delivery of therapeutics , 2014 .
[127] J. Nam,et al. Amyloid-β aggregation with gold nanoparticles on brain lipid bilayer. , 2014, Small.
[128] Rupesh Dudhe,et al. Nanoemulsion: an advanced mode of drug delivery system , 2014, 3 Biotech.
[129] Young Chul Youn,et al. The genetics of Alzheimer’s disease , 2014, Clinical interventions in aging.
[130] H. Ji,et al. Involvement of cysteinyl leukotriene receptor 1 in Aβ1–42-induced neurotoxicity in vitro and in vivo , 2014, Neurobiology of Aging.
[131] W. Wan,et al. The potential mechanisms of Aβ-receptor for advanced glycation end-products interaction disrupting tight junctions of the blood-brain barrier in Alzheimer's disease , 2014, The International journal of neuroscience.
[132] Ajay-Vikram Singh,et al. Nanoparticle enabled drug delivery across the blood brain barrier: in vivo and in vitro models, opportunities and challenges. , 2014, Current pharmaceutical biotechnology.
[133] Qizhi Zhang,et al. Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice. , 2014, Biomaterials.
[134] E. Masliah,et al. Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation. , 2014, Journal of Alzheimer's disease : JAD.
[135] T. Hartmann,et al. Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease , 2013, Front. Aging Neurosci..
[136] T. Golde,et al. γ-Secretase inhibitors and modulators. , 2013, Biochimica et biophysica acta.
[137] M. Stefani,et al. Protein Folding and Aggregation into Amyloid: The Interference by Natural Phenolic Compounds , 2013, International journal of molecular sciences.
[138] Soodabeh Davaran,et al. Liposome: classification, preparation, and applications , 2013, Nanoscale Research Letters.
[139] Huaxi Xu,et al. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy , 2013, Nature Reviews Neurology.
[140] C. Eckman,et al. Endothelin-converting enzymes and related metalloproteases in Alzheimer's disease. , 2012, Journal of Alzheimer's disease : JAD.
[141] D. Michaelson,et al. ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice , 2013, Molecular Neurodegeneration.
[142] J. Dumin,et al. Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models , 2013, Alzheimer's Research & Therapy.
[143] Hong-Qi Yang,et al. Current advances in the treatment of Alzheimer's disease: focused on considerations targeting Aβ and tau , 2012, Translational Neurodegeneration.
[144] Linfeng Wu,et al. β-cyclodextrin-poly(β-amino ester) nanoparticles for sustained drug delivery across the blood-brain barrier. , 2012, Biomacromolecules.
[145] B. Hyman,et al. Soluble forms of tau are toxic in Alzheimer’s disease , 2012, Translational neuroscience.
[146] I. Deary,et al. The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk , 2012, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[147] Tim West,et al. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis , 2012, Proceedings of the National Academy of Sciences.
[148] K. Blennow,et al. Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease. , 2012, Archives of neurology.
[149] L. Mucke,et al. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. , 2012, Cold Spring Harbor perspectives in medicine.
[150] W. Scheper,et al. PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease. , 2012, ACS nano.
[151] L. Chew,et al. The Toxicity of Amyloid β Oligomers , 2012, International journal of molecular sciences.
[152] D. Selkoe,et al. Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.
[153] Laura M Ensign,et al. Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. , 2012, Advanced drug delivery reviews.
[154] Bernardo L Sabatini,et al. Synapses and Alzheimer's disease. , 2012, Cold Spring Harbor perspectives in biology.
[155] S. Jo,et al. Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer’s Disease , 2012, Biomolecules & therapeutics.
[156] C. Borchers,et al. Structure and dynamics of small soluble Aβ(1-40) oligomers studied by top-down hydrogen exchange mass spectrometry. , 2012, Biochemistry.
[157] Nick C Fox,et al. Brain imaging in Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.
[158] T. Maekawa,et al. Curcumin Loaded-PLGA Nanoparticles Conjugated with Tet-1 Peptide for Potential Use in Alzheimer's Disease , 2012, PloS one.
[159] M. Grimaldi,et al. The iAβ5p β-breaker peptide regulates the Aβ(25-35) interaction with lipid bilayers through a cholesterol-mediated mechanism. , 2012, Biochemical and biophysical research communications.
[160] L. Reijmers,et al. Natural Amyloid-Beta Oligomers Acutely Impair the Formation of a Contextual Fear Memory in Mice , 2012, PloS one.
[161] Sterling C. Johnson,et al. The effects of ramipril in individuals at risk for Alzheimer's disease: results of a pilot clinical trial. , 2012, Journal of Alzheimer's disease : JAD.
[162] A. Lönneborg. Biomarkers for Alzheimer Disease in Cerebrospinal Fluid, Urine, and Blood , 2012, Molecular Diagnosis & Therapy.
[163] Linda Zhang,et al. Current neuroimaging techniques in Alzheimer's disease and applications in animal models. , 2012, American journal of nuclear medicine and molecular imaging.
[164] L. Breydo,et al. Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice , 2012, Molecular Neurodegeneration.
[165] D. I. Lewis,et al. Effect of Sodium Valproate Administration on Brain Neprilysin Expression and Memory in Rats , 2012, Journal of Molecular Neuroscience.
[166] R. Rodriguiz,et al. Mice deficient in endothelin‐converting enzyme‐2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord , 2011, Journal of neurochemistry.
[167] Anand Viswanathan,et al. Cerebral amyloid angiopathy in the elderly , 2011, Annals of neurology.
[168] E. Génin,et al. No replication of genetic association between candidate polymorphisms and Alzheimer's disease , 2011, Neurobiology of Aging.
[169] R. Tycko. Solid-state NMR studies of amyloid fibril structure. , 2011, Annual review of physical chemistry.
[170] D. Hinton,et al. Protein Kinase C-Regulated Aβ Production and Clearance , 2011, International journal of Alzheimer's disease.
[171] Kaj Blennow,et al. Cerebrospinal fluid protein biomarkers for Alzheimer’s disease , 2004, NeuroRX.
[172] J. Dunys,et al. γ-Secretase-mediated regulation of neprilysin: influence of cell density and aging and modulation by imatinib. , 2011, Journal of Alzheimer's disease : JAD.
[173] D. Kovacs,et al. The many substrates of presenilin/γ-secretase. , 2011, Journal of Alzheimer's disease : JAD.
[174] M. Owen,et al. A multi-center study of ACE and the risk of late-onset Alzheimer's disease. , 2011, Journal of Alzheimer's disease : JAD.
[175] Ruth Nussinov,et al. β-Barrel topology of Alzheimer's β-amyloid ion channels. , 2010, Journal of molecular biology.
[176] Sandip S Chavhan,et al. Rivastigmine-loaded PLGA and PBCA nanoparticles: preparation, optimization, characterization, in vitro and pharmacodynamic studies. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[177] Wenwei Tang,et al. Lactoferrin-modified procationic liposomes as a novel drug carrier for brain delivery. , 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[178] A. Ludolph,et al. Efficient processing of Alzheimer's disease amyloid-Beta peptides by neuroectodermally converted mesenchymal stem cells. , 2010, Stem cells and development.
[179] K. Dawson,et al. Dual effect of amino modified polystyrene nanoparticles on amyloid β protein fibrillation. , 2010, ACS chemical neuroscience.
[180] D. Kaplan,et al. Mechanisms of enzymatic degradation of amyloid Beta microfibrils generating nanofilaments and nanospheres related to cytotoxicity. , 2010, Biochemistry.
[181] D. Connor,et al. The Alzheimer's questionnaire: a proof of concept study for a new informant-based dementia assessment. , 2010, Journal of Alzheimer's disease : JAD.
[182] George Perry,et al. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. , 2010, Biochimica et biophysica acta.
[183] Gregory J Brewer,et al. Amyloid-β as a modulator of synaptic plasticity. , 2010, Journal of Alzheimer's disease : JAD.
[184] D. Walsh,et al. Alzheimer's disease: synaptic dysfunction and Aβ , 2009, Molecular Neurodegeneration.
[185] T. Wyss-Coray,et al. The p75 Neurotrophin Receptor Promotes Amyloid-β(1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo , 2009, The Journal of Neuroscience.
[186] Yong Shen,et al. Searching for Disease Modifiers—PKC Activation and HDAC Inhibition—A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress , 2009, ChemMedChem.
[187] S. Love,et al. Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta. , 2009, The American journal of pathology.
[188] S. Mukherjee,et al. Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System , 2009, Indian journal of pharmaceutical sciences.
[189] E. Siemers,et al. Development of semagacestat (LY450139), a functional γ-secretase inhibitor, for the treatment of Alzheimer's disease , 2009, Expert Opinion on Pharmacotherapy.
[190] Rajesh Singh,et al. Nanoparticle-based targeted drug delivery. , 2009, Experimental and molecular pathology.
[191] Hong-Qi Yang,et al. Involvement of protein trafficking in deprenyl-induced alpha-secretase activity regulation in PC12 cells. , 2009, European journal of pharmacology.
[192] S. Mandel,et al. Simultaneous Manipulation of Multiple Brain Targets by Green Tea Catechins: A Potential Neuroprotective Strategy for Alzheimer and Parkinson Diseases , 2008, CNS neuroscience & therapeutics.
[193] Khadija Iqbal,et al. Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease. , 2008, Current medicinal chemistry.
[194] Seth Love,et al. Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial , 2008, The Lancet.
[195] R. Rodriguiz,et al. Animals lacking endothelin‐converting enzyme‐2 are deficient in learning and memory , 2008, Genes, brain, and behavior.
[196] S. Hendrix,et al. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial , 2008, The Lancet Neurology.
[197] G. Bitan,et al. Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders. , 2008, Current Alzheimer research.
[198] J. Lau,et al. Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. , 2008, Archives of internal medicine.
[199] E. Powers,et al. Mechanisms of protein fibril formation: nucleated polymerization with competing off-pathway aggregation. , 2008, Biophysical journal.
[200] S. Gauthier,et al. Alzhemed: a potential treatment for Alzheimer's disease. , 2007, Current Alzheimer research.
[201] F. Maxfield,et al. Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. , 2007, Molecular biology of the cell.
[202] A. Lustig,et al. Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues. , 2007, Experimental cell research.
[203] D. Blacker,et al. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database , 2007, Nature Genetics.
[204] L. Liaudet,et al. Nitric oxide and peroxynitrite in health and disease. , 2007, Physiological reviews.
[205] Michael H. Hecht,et al. Generic hydrophobic residues are sufficient to promote aggregation of the Alzheimer's Aβ42 peptide , 2006, Proceedings of the National Academy of Sciences.
[206] David M Holtzman,et al. Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo , 2006, Nature Medicine.
[207] L. Fenart,et al. Methylated β-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood–brain barrier , 2006 .
[208] F. Chiti. Relative Importance of Hydrophobicity, Net Charge, and Secondary Structure Propensities in Protein Aggregation , 2006 .
[209] A. Gliozzi,et al. β-Amyloid Is Different in Normal Aging and in Alzheimer Disease* , 2005, Journal of Biological Chemistry.
[210] B. Hyman,et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[211] H. Arai,et al. Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease , 2005, Annals of neurology.
[212] Pritam Das,et al. Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production , 2005, Nature Medicine.
[213] M. Kirkitadze,et al. Molecular mechanisms initiating amyloid beta-fibril formation in Alzheimer's disease. , 2005, Acta biochimica Polonica.
[214] J. Schwartz,et al. Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease , 2004, Molecular Psychiatry.
[215] L. Hersh,et al. Estrogen regulates neprilysin activity in rat brain , 2004, Neuroscience Letters.
[216] E. Godaux,et al. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. , 2004, The Journal of clinical investigation.
[217] S. Robinson,et al. Physiological Roles of Amyloid-β and Implications for its Removal in Alzheimer’s Disease , 2004, Drugs & aging.
[218] C. Dobson,et al. Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution , 2003, Journal of Molecular Medicine.
[219] B. Dubois,et al. Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization , 2003, Neurology.
[220] Wickliffe C Abraham,et al. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory , 2003, Progress in Neurobiology.
[221] L. Feuk,et al. Haplotypes extending across ACE are associated with Alzheimer's disease. , 2003, Human molecular genetics.
[222] W. Oertel,et al. Treatment with the selective muscarinic ml agonist talsaclidine decreases cerebrospinal fluid levels of Aβ42 in patients with Alzheimer's disease , 2003, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.
[223] M. Rossor. Contribution of cerebral amyloid angiopathy to Alzheimer ’ s disease , 2003 .
[224] W. Gong,et al. Potential role of the formyl peptide receptor‐like 1 (FPRL1) in inflammatory aspects of Alzheimer’s disease , 2002, Journal of leukocyte biology.
[225] J. Hardy,et al. The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .
[226] T. Saido,et al. Generation of amyloid β peptide with pyroglutamate at position 3 in primary cortical neurons , 2002, Neuroscience Letters.
[227] R. Doms,et al. Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression. , 2002, Biochemistry.
[228] T. Iwatsubo,et al. Neprilysin Degrades Both Amyloid β Peptides 1–40 and 1–42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases* , 2001, The Journal of Biological Chemistry.
[229] P. Mcgeer,et al. Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide , 2001, Neuroscience Letters.
[230] R. Katzman.,et al. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. , 2000, The Journal of clinical investigation.
[231] R. Weller,et al. Cerebral Amyloid Angiopathy: Accumulation of Aβ in Interstitial Fluid Drainage Pathways in Alzheimer's Disease , 2000, Annals of the New York Academy of Sciences.
[232] J. Treanor,et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. , 1999, Science.
[233] C. Parsons,et al. Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data , 1999, Neuropharmacology.
[234] H. Orzechowski,et al. Human endothelin-converting enzyme-1 beta mRNA expression is regulated by an alternative promoter. , 1998, Journal of cardiovascular pharmacology.
[235] R. Motter,et al. Amyloid precursor protein processing and Aβ42 deposition in a transgenic mouse model of Alzheimer disease , 1997 .
[236] M. Yanagisawa,et al. Endothelin-converting Enzyme-2 Is a Membrane-bound, Phosphoramidon-sensitive Metalloprotease with Acidic pH Optimum (*) , 1995, The Journal of Biological Chemistry.
[237] P. Powchick,et al. Tacrine , 1995, The Lancet.