The Na-H exchanger revisited: an update on Na-H exchange regulation and the role of the exchanger in hypertension and cardiac function in health and disease.

[1]  M. Karmazyn,et al.  Interaction between Anesthetics and the Sodium‐Hydrogen Exchange Inhibitor HOE 642 (Cariporide) in Ischemic and Reperfused Rat Hearts , 1997, Anesthesiology.

[2]  M. Galiñanes,et al.  Na+/H+ exchanger activity does not contribute to protection by ischemic preconditioning in the isolated rat heart. , 1997, Circulation.

[3]  M. Karmazyn,et al.  A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). , 1997, Journal of molecular and cellular cardiology.

[4]  L. Ng,et al.  Activity and expression of Na(+)-H+ exchanger isoforms 1 and 3 in kidney proximal tubules of hypertensive rats. , 1997, Circulation research.

[5]  M. Karmazyn,et al.  Effect of sodium-hydrogen exchange inhibition on functional and metabolic impairment produced by oxidative stress in the isolated rat heart. , 1997, Canadian journal of physiology and pharmacology.

[6]  B. Alvarez,et al.  Dissociation between positive inotropic and alkalinizing effects of angiotensin II in feline myocardium. , 1997, The American journal of physiology.

[7]  K. Shimamoto,et al.  Infarct size limitation by a new Na(+)-H+ exchange inhibitor, Hoe 642: difference from preconditioning in the role of protein kinase C. , 1997, Journal of the American College of Cardiology.

[8]  L. Ng,et al.  Calcium-induced activation of the rat vascular myocyte Na+/H+ exchanger isoform-1. , 1997, Metabolism: clinical and experimental.

[9]  D. Lagadic-Gossmann,et al.  Modulation by pH0 and intracellular Ca2+ of Na(+)-H+ exchange in diabetic rat isolated ventricular myocytes. , 1997, Circulation research.

[10]  J. Pouysségur,et al.  The p42/p44 Mitogen-activated Protein Kinase Cascade Is Determinant in Mediating Activation of the Na+/H+ Exchanger (NHE1 Isoform) in Response to Growth Factors* , 1997, The Journal of Biological Chemistry.

[11]  S. Grinstein,et al.  Muscarinic Agonists Induce Phosphorylation-independent Activation of the NHE-1 Isoform of the Na+/H+ Antiporter in Salivary Acinar Cells* , 1997, The Journal of Biological Chemistry.

[12]  M. Karmazyn,et al.  Na(+)-H+ exchange inhibition protects against mechanical, ultrastructural, and biochemical impairment induced by low concentrations of lysophosphatidylcholine in isolated rat hearts. , 1997, Circulation research.

[13]  M. Yasutake,et al.  Cardiac Na+-H+ exchanger during postnatal development in the rat: changes in mRNA expression and sarcolemmal activity. , 1997, Journal of molecular and cellular cardiology.

[14]  J. Pouysségur,et al.  Molecular physiology of vertebrate Na+/H+ exchangers. , 1997, Physiological reviews.

[15]  J. Díez,et al.  Angiotensin converting enzyme inhibition corrects Na+/H+ exchanger overactivity in essential hypertension. , 1997, American journal of hypertension.

[16]  B. Lorell,et al.  Endothelin and angiotensin II stimulation of Na+-H+ exchange is impaired in cardiac hypertrophy. , 1997, The Journal of clinical investigation.

[17]  K. Hashimoto,et al.  Antiarrhythmic effects of HOE642, a novel Na(+)-H+ exchange inhibitor, on ventricular arrhythmias in animal hearts. , 1996, European journal of pharmacology.

[18]  K. Patel,et al.  Intracellular protons inhibit transient outward K+ current in ventricular myocytes from diabetic rats. , 1996, The American journal of physiology.

[19]  M. Karmazyn.  The sodium-hydrogen exchange system in the heart: its role in ischemic and reperfusion injury and therapeutic implications. , 1996, The Canadian journal of cardiology.

[20]  A. King,et al.  Thrombin activates the sarcolemmal Na(+)-H+ exchanger. Evidence for a receptor-mediated mechanism involving protein kinase C. , 1996, Circulation research.

[21]  D. Barber,et al.  Gα12 Differentially Regulates Na+-H+ Exchanger Isoforms* , 1996, The Journal of Biological Chemistry.

[22]  D. Barber,et al.  Activation of Na (cid:49) -H (cid:49) Exchange Is Necessary for RhoA-induced Stress Fiber Formation* , 2022 .

[23]  M. Karmazyn.  Editorial: Sodium-hydrogen exchange inhibition—superior cardioprotective strategy , 1996 .

[24]  I. Kodama,et al.  Protective effects of dimethyl amiloride against postischemic myocardial dysfunction in rabbit hearts: phosphorus 31-nuclear magnetic resonance measurements of intracellular pH and cellular energy. , 1996, The Journal of thoracic and cardiovascular surgery.

[25]  L. Fliegel,et al.  Regulation of Na+/H+ Exchanger Gene Expression , 1996, The Journal of Biological Chemistry.

[26]  M. Villereal,et al.  Examination of the role for Ca2+ in regulation and phosphorylation of the Na+/H+ antiporter NHE1 via mitogen and hypertonic stimulation , 1996, Journal of cellular physiology.

[27]  D. Gruol,et al.  Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis. , 1996, The Journal of clinical investigation.

[28]  O. Schanne,et al.  Modulation of the electrophysiological effects of ischemia reperfusion by methylisobutyl amiloride. , 1996, Journal of molecular and cellular cardiology.

[29]  S. Grinstein,et al.  Coimmunoprecipitation of a 24-kDa protein with NHE1, the ubiquitous isoform of the Na+/H+ exchanger. , 1996, The American journal of physiology.

[30]  M. Karmazyn,et al.  Improved cardiac function after prolonged hypothermic ischemia with the Na+/H+ exchange inhibitor HOE 694. , 1996, The Annals of thoracic surgery.

[31]  T. Suzuki,et al.  Beneficial effect of amiloride, A Na(+)-H+ exchange blocker, in a murine model of dilated cardiomyopathy. , 1996, Research communications in molecular pathology and pharmacology.

[32]  D. Ellis,et al.  Intracellular pH and intrinsic H+ buffering capacity in normal and hypertrophied right ventricle of ferret heart. , 1996, Cardiovascular research.

[33]  L. Fliegel,et al.  Regulation of NHE1 expression in L6 muscle cells. , 1996, Biochimica et biophysica acta.

[34]  L. Ng,et al.  Phorbol ester activation of the rat vascular myocyte Na(+)-H(+) exchanger isoform 1. , 1996, Hypertension.

[35]  L. Bianchini,et al.  Regulation of the Na+/H+ exchanger isoform NHE1: role of phosphorylation. , 1996, Kidney international.

[36]  山田 卓史.  Myocardial recovery during post-ischemic reperfusion : optimal concentrations of Na[+] and Ca[2+] in the reperfusate and protective effects of amiloride added to cardioplegic solution , 1996 .

[37]  D. Barber,et al.  G13 Stimulates Na-H Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways (*) , 1996, The Journal of Biological Chemistry.

[38]  M. Donowitz,et al.  Hyperosmolarity inhibits the Na+/H+ exchanger isoforms NHE2 and NHE3: an effect opposite to that on NHE1. , 1996, The American journal of physiology.

[39]  G. Navon,et al.  The relation between cellular sodium, pH and volumes and the activity of Na/H antiport during hypothermic ischemia: multinuclear NMR studies of rat hearts. , 1996, Journal of molecular and cellular cardiology.

[40]  M. Avkiran,et al.  Impact of extracellular buffer composition on cardioprotective efficacy of Na+/H+ exchanger inhibitors. , 1996, The American journal of physiology.

[41]  L. Fliegel.  The Na+/H+ exchanger , 1996 .

[42]  M. Karmazyn.  Sodium-hydrogen exchange inhibition--a superior cardioprotective strategy. , 1996, The Journal of thoracic and cardiovascular surgery.

[43]  M. Karmazyn.  The role of endothelins in cardiac function in health and disease. , 1996, EXS.

[44]  D. Feuvray.  Response to ischemia and reperfusion by the diabetic heart. , 1996, EXS.

[45]  M. Avkiran.  Sodium-hydrogen exchange in myocardial ischemia and reperfusion: a critical determinant of injury? , 1996, EXS.

[46]  L. Fliegel,et al.  Regulation of NHE-1 promoter in mammalian myocardium. , 1996, The American journal of physiology.

[47]  M. Karmazyn.  Myocardial Ischemia: Mechanisms, Reperfusion, Protection , 1996, EXS.

[48]  J. Hanrahan,et al.  Plasma Membrane Na+/H+ Exchanger Isoforms (NHE-1, −2, and −3) Are Differentially Responsive to Second Messenger Agonists of the Protein Kinase A and C Pathways (*) , 1995, The Journal of Biological Chemistry.

[49]  N. Madias,et al.  Role of C/EBP proteins in hepatic and vascular smooth muscle transcription of human NHE1 gene. , 1995, The American journal of physiology.

[50]  M. Shigekawa,et al.  Mechanisms of reoxygenation-induced calcium overload in cardiac myocytes: dependence on pHi. , 1995, The Journal of surgical research.

[51]  B. Thompson,et al.  Na+/H+ exchange in pulmonary artery smooth muscle from spontaneously hypertensive and Wistar-Kyoto rats. , 1995, The American journal of physiology.

[52]  G. Lopaschuk,et al.  Ischemic preconditioning inhibits glycolysis and proton production in isolated working rat hearts. , 1995, The American journal of physiology.

[53]  R. Deslauriers,et al.  Protective effect of amiloride during hypothermic hyperkalemic preservation: a 31P NMR study in isolated pig hearts. , 1995, Journal of molecular and cellular cardiology.

[54]  S. Grinstein,et al.  Responsiveness of mutants of NHE1 isoform of Na+/H+ antiport to osmotic stress. , 1995, The American journal of physiology.

[55]  W. Siffert,et al.  Sodium-proton exchange and primary hypertension. An update. , 1995, Hypertension.

[56]  R. Ramasamy,et al.  Ischemic preconditioning stimulates sodium and proton transport in isolated rat hearts. , 1995, The Journal of clinical investigation.

[57]  L. Fliegel,et al.  The carboxyl-terminal region of the Na+/H+ exchanger interacts with mammalian heat shock protein. , 1995, Biochemistry.

[58]  R. Bohle,et al.  Myocardial Protection by Na+-H+ Exchange Inhibition in Ischemic, Reperfused Porcine Hearts , 1995 .

[59]  H. Matsuda,et al.  Inhibition of Na+/H+ exchanger attenuates neutrophil-mediated reperfusion injury. , 1995, The Annals of thoracic surgery.

[60]  G. Radda,et al.  Altered Na(+)- H(+)- exchange activity in the spontaneously hypertensive perfused rat heart. , 1995, Journal of molecular and cellular cardiology.

[61]  J. Jarmakani,et al.  Developmental changes in mRNA encoding cardiac Na+/H+ exchanger (NHE-1) in rabbit. , 1995, Biochemical and biophysical research communications.

[62]  R. Putnam,et al.  Shrinkage-induced activation of Na+/H+ exchange in primary rat astrocytes: role of myosin light-chain kinase. , 1995, The American journal of physiology.

[63]  E. Czarnowska,et al.  Combined therapy with dimethylthiourea, diltiazem and amiloride/dimethylamiloride in the ischemic/reperfused heart. , 1995, Cardiovascular research.

[64]  S. Brant,et al.  Mammalian Na+/H+ exchanger gene family: structure and function studies. , 1995, The American journal of physiology.

[65]  L. Fliegel,et al.  Specific Activation of the Na/H Exchanger Gene during Neuronal Differentiation of Embryonal Carcinoma Cells (*) , 1995, The Journal of Biological Chemistry.

[66]  B. Krolewski,et al.  Na(+)-H+ antiporter phenotype, abundance, and phosphorylation of immortalized lymphoblasts from humans with hypertension. , 1995, Hypertension.

[67]  Y. Ladilov,et al.  Protection of reoxygenated cardiomyocytes against hypercontracture by inhibition of Na+/H+ exchange. , 1995, The American journal of physiology.

[68]  R. Ramasamy,et al.  Effects of glycogen depletion on ischemic injury in isolated rat hearts: insights into preconditioning. , 1995, The American journal of physiology.

[69]  M. Leppert,et al.  Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1. , 1995, Genomics.

[70]  L. Fliegel,et al.  Molecular biology of the cardiac sodium/hydrogen exchanger. , 1995, Cardiovascular research.

[71]  K. Spitzer,et al.  Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. , 1995, Cardiovascular research.

[72]  J. Pouysségur,et al.  Structure-function studies and molecular regulation of the growth factor activatable sodium-hydrogen exchanger (NHE-1). , 1995, Cardiovascular research.

[73]  D. Rosskopf,et al.  Role of sodium-hydrogen exchange in the proliferation of immortalised lymphoblasts from patients with essential hypertension and normotensive subjects. , 1995, Cardiovascular research.

[74]  W. Linz,et al.  Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. , 1995, Cardiovascular research.

[75]  K. Ytrehus,et al.  Inhibition of sodium-hydrogen exchange reduces infarct size in the isolated rat heart--a protective additive to ischaemic preconditioning. , 1995, Cardiovascular research.

[76]  M. Pucéat,et al.  Neurohumoral modulation of intracellular pH in the heart. , 1995, Cardiovascular research.

[77]  L. Fliegel,et al.  Activation of the Na/H Exchanger Gene by the Transcription Factor AP-2 (*) , 1995, The Journal of Biological Chemistry.

[78]  M. Czubryt,et al.  The contribution of ionic contribution of ionic imbalance to ischemia/reperfusion-induced injury , 1995 .

[79]  RyozoNagai,et al.  Salt-Sensitive Hypertension in Transgenic Mice Overexpressing Na+-Proton Exchanger , 1995 .

[80]  D. Rosskopf,et al.  Kinetics of Na+/H+ exchange in vascular smooth muscle cells from WKY and SHR: effects of phorbol ester. , 1995, The American journal of physiology.

[81]  D. Batlle,et al.  Na+/H+ antiporter (NHE-1 isoform) in cultured vascular smooth muscle from the spontaneously hypertensive rat. , 1995, Kidney International.

[82]  R. Bohle,et al.  Myocardial protection by Na(+)-H+ exchange inhibition in ischemic, reperfused porcine hearts. , 1995, Circulation.

[83]  R. Miller,et al.  G alpha q and G alpha 13 regulate NHE-1 and intracellular calcium in epithelial cells. , 1995, The American journal of physiology.

[84]  M. Donowitz,et al.  Structure/function studies of mammalian Na‐H exchangers‐‐an update. , 1995, The Journal of physiology.

[85]  M. Czubryt,et al.  The contribution of ionic imbalance to ischemia/reperfusion-induced injury. , 1995, Journal of molecular and cellular cardiology.

[86]  Y. Hiroi,et al.  Salt-sensitive hypertension in transgenic mice overexpressing Na(+)-proton exchanger. , 1995, Circulation research.

[87]  W. Fantl,et al.  Activation of Na+/H+ exchange by platelet-derived growth factor involves phosphatidylinositol 3'-kinase and phospholipase C gamma. , 1994, The Journal of biological chemistry.

[88]  M. Yasutake,et al.  Na+/H+ exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor. , 1994, The American journal of physiology.

[89]  B. Berk,et al.  Na(+)-H+ exchanger expression in vascular smooth muscle of spontaneously hypertensive and Wistar-Kyoto rats. , 1994, Hypertension.

[90]  G. Navon,et al.  31P NMR and triple quantum filtered 23Na NMR studies of the effects of inhibition of Na+/H+ exchange on intracellular sodium and pH in working and ischemic hearts , 1994, Magnetic resonance in medicine.

[91]  M. Karmazyn,et al.  Role of Na(+)-H+ exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts. , 1994, Circulation research.

[92]  R. Vaughan-Jones,et al.  Effect of metabolic inhibitors and second messengers upon Na(+)‐H+ exchange in the sheep cardiac Purkinje fibre. , 1994, The Journal of physiology.

[93]  L. Ng,et al.  Sodium–hydrogen antiporter protein in normotensive Wistar–Kyoto rats and spontaneously hypertensive rats , 1994, Journal of hypertension.

[94]  Y. Hiroi,et al.  SALT-SENSITIVE HYPERTENSION IN TRANSGENIC MICE OVEREXPRESSING SODIUM-PROTON EXCHANGER , 1994 .

[95]  P. van Hecke,et al.  New Na(+)-H+ exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca2+ overload in isolated perfused rabbit heart. , 1994, Circulation.

[96]  J. Pouysségur,et al.  Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defective. , 1994, The Journal of biological chemistry.

[97]  J. Pouysségur,et al.  The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites. , 1994, The Journal of biological chemistry.

[98]  Y. Goto,et al.  Stunned myocardium after rapid correction of acidosis. Increased oxygen cost of contractility and the role of the Na(+)-H+ exchange system. , 1994, Circulation research.

[99]  N. Dhanasekaran,et al.  Protein kinase C-dependent and -independent activation of Na+/H+ exchanger by G alpha 12 class of G proteins. , 1994, The Journal of biological chemistry.

[100]  S. Grinstein,et al.  ATP dependence of NHE-1, the ubiquitous isoform of the Na+/H+ antiporter. Analysis of phosphorylation and subcellular localization. , 1994, The Journal of biological chemistry.

[101]  B. Conklin,et al.  G alpha 13 stimulates Na-H exchange. , 1994, The Journal of biological chemistry.

[102]  N. Madias,et al.  Proximal regulatory elements and nuclear activities required for transcription of the human Na+/H+ exchanger (NHE-1) gene. , 1994, Biochimica et biophysica acta.

[103]  H. C. Smith,et al.  Specific 3' sequences flanking a minimal apolipoprotein B (apoB) mRNA editing 'cassette' are critical for efficient editing in vitro. , 1994, Biochimica et biophysica acta.

[104]  W. Schaper,et al.  Effects of a New Na+/H+ Antiporter Inhibitor on Postischemic Reperfusion in Pig Heart , 1994, Journal of cardiovascular pharmacology.

[105]  R. Weiss,et al.  Importance of metabolic inhibition and cellular pH in mediating preconditioning contractile and metabolic effects in rat hearts. , 1994, Circulation research.

[106]  L. Fliegel,et al.  The Na+/H+ exchanger: an update on structure, regulation and cardiac physiology. , 1993, The Biochemical journal.

[107]  D. Rosskopf,et al.  Hypertensive sodium-proton exchanger phenotype persists in immortalized lymphoblasts from essential hypertensive patients. A cell culture model for human hypertension. , 1993, The Journal of clinical investigation.

[108]  M. Wu,et al.  The modulatory effects of endothelin‐1, carbachol and isoprenaline upon Na(+)‐H+ exchange in dog cardiac Purkinje fibres. , 1993, The Journal of physiology.

[109]  P. Igarashi,et al.  NHE3: a Na+/H+ exchanger isoform of renal brush border. , 1993, The American journal of physiology.

[110]  W. Linz,et al.  Hoe 694, a new Na+/H+ exchange inhibitor and its effects in cardiac ischaemia , 1993, British journal of pharmacology.

[111]  M. Karmazyn.  Na+/H+ exchange inhibitors reverse lactate‐induced depression in postischaemic ventricular recovery , 1993, British journal of pharmacology.

[112]  R. London,et al.  Mechanism of preconditioning. Ionic alterations. , 1993, Circulation research.

[113]  M. Wallert,et al.  Alpha 1-adrenergic stimulation of Na-H exchange in cardiac myocytes. , 1992, The American journal of physiology.

[114]  G. Asimakis,et al.  Ischemic preconditioning attenuates acidosis and postischemic dysfunction in isolated rat heart. , 1992, The American journal of physiology.

[115]  W. Linz,et al.  Effects of Na+/H+ exchange inhibitors in cardiac ischemia. , 1992, Journal of molecular and cellular cardiology.

[116]  C. Sardet,et al.  The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing". , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[117]  J. Kentish,et al.  Effects of changes of pH on the contractile function of cardiac muscle. , 1990, The American journal of physiology.

[118]  P. Weissberg,et al.  The pH of spontaneously beating cultured rat heart cells is regulated by an ATP-calmodulin-dependent Na+/H+ antiport. , 1989, Circulation research.