Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease.

Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are serious health problems worldwide. These two diseases have similar pathological spectra, ranging from simple hepatic steatosis to steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. Although most subjects with excessive alcohol or food intake experience simple hepatic steatosis, a small percentage of individuals will develop progressive liver disease. Notably, both ALD and NAFLD are frequently accompanied by extrahepatic complications, including cardiovascular disease and malignancy. The survival of patients with ALD and NAFLD depends on various disease-associated conditions. This review delineates the clinical characteristics and outcomes of patients with ALD and NAFLD by comparing their epidemiology, the factors associated with disease susceptibility and progression, and the predictors and characteristics of outcomes. A comprehensive understanding of the characteristics and outcomes of ALD and NAFLD is imperative in the management of these chronic liver diseases.

[1]  V. de Lédinghen,et al.  Controlled attenuation parameter (CAP) for the diagnosis of steatosis: a prospective study of 5323 examinations. , 2014, Journal of hepatology.

[2]  Lai Wei,et al.  Effect of abstinence from alcohol on survival of patients with alcoholic cirrhosis: A systematic review and meta‐analysis , 2014, Hepatology research : the official journal of the Japan Society of Hepatology.

[3]  R. Kaushik,et al.  Model for End‐Stage Liver Disease score versus Maddrey Discriminant Function score in assessing short‐term outcome in alcoholic hepatitis , 2014, Journal of gastroenterology and hepatology.

[4]  A. Burt,et al.  Clinical but not histological factors predict long‐term prognosis in patients with histologically advanced non‐decompensated alcoholic liver disease , 2014, Liver international : official journal of the International Association for the Study of the Liver.

[5]  A. Stanley,et al.  The management of alcoholic hepatitis: a prospective comparison of scoring systems , 2013, Alimentary pharmacology & therapeutics.

[6]  Z. Younossi,et al.  Mortality associated with alcohol‐related liver disease , 2013, Alimentary pharmacology & therapeutics.

[7]  K. Straif,et al.  Recent evidence on alcohol and cancer epidemiology. , 2013, Future oncology.

[8]  M. Brankovic,et al.  Alcoholic liver disease/nonalcoholic fatty liver disease index: distinguishing alcoholic from nonalcoholic fatty liver disease , 2013, European journal of gastroenterology & hepatology.

[9]  Jian-Gao Fan,et al.  Epidemiology of alcoholic and nonalcoholic fatty liver disease in China , 2013, Journal of gastroenterology and hepatology.

[10]  Jürgen Rehm,et al.  Global burden of alcoholic liver diseases. , 2013, Journal of hepatology.

[11]  Eliseo Guallar,et al.  Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994. , 2013, American journal of epidemiology.

[12]  H. Makhlouf,et al.  Predictors of All-Cause Mortality and Liver-Related Mortality in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD) , 2013, Digestive Diseases and Sciences.

[13]  T. Kitamoto,et al.  Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan , 2013, Human Genetics.

[14]  Z. Younossi,et al.  In patients with non-alcoholic fatty liver disease, metabolically abnormal individuals are at a higher risk for mortality while metabolically normal individuals are not. , 2013, Metabolism: clinical and experimental.

[15]  Sombat Treeprasertsuk,et al.  NAFLD fibrosis score: a prognostic predictor for mortality and liver complications among NAFLD patients. , 2013, World journal of gastroenterology.

[16]  R. Moreau,et al.  PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis. , 2013, Journal of hepatology.

[17]  H. El‐Serag,et al.  Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. , 2012, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[18]  T. Arisawa,et al.  Comparison of the relationships of alcoholic and nonalcoholic fatty liver with hypertension, diabetes mellitus, and dyslipidemia , 2012, Journal of clinical biochemistry and nutrition.

[19]  J. Reinus,et al.  Prevalence and natural history of alcoholic liver disease. , 2012, Clinics in liver disease.

[20]  S. Weinman,et al.  The Interaction of rs738409, Obesity, and Alcohol: A Population-Based Autopsy Study , 2012, The American Journal of Gastroenterology.

[21]  M. Duvnjak,et al.  Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease. , 2012, World journal of gastroenterology.

[22]  S. Sookoian,et al.  The genetic epidemiology of nonalcoholic fatty liver disease: toward a personalized medicine. , 2012, Clinics in liver disease.

[23]  J. Vergniol,et al.  Non‐invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[24]  A. Pollett,et al.  Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography , 2012, Liver international : official journal of the International Association for the Study of the Liver.

[25]  T. Saibara,et al.  Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese , 2012, PloS one.

[26]  H. Tillmann,et al.  Different patterns of decompensation in patients with alcoholic vs. non‐alcoholic liver cirrhosis , 2012, Alimentary pharmacology & therapeutics.

[27]  A. Tsung,et al.  Outcomes of curative treatment for hepatocellular cancer in nonalcoholic steatohepatitis versus hepatitis C and alcoholic liver disease , 2012, Hepatology.

[28]  H. Grønbæk,et al.  Cirrhosis and mortality risks of biopsy‐verified alcoholic pure steatosis and steatohepatitis: a nationwide registry‐based study , 2012, Alimentary pharmacology & therapeutics.

[29]  J. Wands,et al.  Insulin Resistance, Ceramide Accumulation, and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease , 2012, Oxidative medicine and cellular longevity.

[30]  L. Ferrell,et al.  Ethnicity and nonalcoholic fatty liver disease , 2012, Hepatology.

[31]  T. Saibara,et al.  Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study , 2012, Journal of Gastroenterology.

[32]  Yoshiyuki Suzuki,et al.  Large-Scale Long-Term Follow-Up Study of Japanese Patients With Non-Alcoholic Fatty Liver Disease for the Onset of Hepatocellular Carcinoma , 2012, The American Journal of Gastroenterology.

[33]  G. Ioannou,et al.  Excellent posttransplant survival for patients with nonalcoholic steatohepatitis in the United States , 2012, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[34]  M. Kudo,et al.  Clinical Characteristics of Non-B Non-C Hepatocellular Carcinoma: A Single-Center Retrospective Study , 2011, Digestion.

[35]  J. Hampe,et al.  Genetic determinants of alcoholic liver disease , 2011, Gut.

[36]  F. Lammert,et al.  The PNPLA3 rs738409 148M/M Genotype Is a Risk Factor for Liver Cancer in Alcoholic Cirrhosis but Shows No or Weak Association in Hepatitis C Cirrhosis , 2011, PloS one.

[37]  R. Solá,et al.  Long-term Clinical Course of Decompensated Alcoholic Cirrhosis: A Prospective Study of 165 Patients , 2011, Journal of clinical gastroenterology.

[38]  Giorgio Saracco,et al.  The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study , 2011, Hepatology.

[39]  A. van de Wiel.  The Effect of Alcohol on Postprandial and Fasting Triglycerides , 2011, International journal of vascular medicine.

[40]  J. Shaw,et al.  Validation of the non‐alcoholic fatty liver disease activity score , 2011, Alimentary pharmacology & therapeutics.

[41]  S. Sookoian,et al.  Meta‐analysis of the influence of I148M variant of patatin‐like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease , 2011, Hepatology.

[42]  J. Ertle,et al.  Non‐alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis , 2011, International journal of cancer.

[43]  T. Saibara,et al.  Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population , 2011, BMC Gastroenterology.

[44]  C. Day,et al.  Genetic determinants of susceptibility and severity in nonalcoholic fatty liver disease , 2011, Expert review of gastroenterology & hepatology.

[45]  P. Schirmacher,et al.  Histopathological diagnosis of non-alcoholic and alcoholic fatty liver disease , 2011, Virchows Archiv.

[46]  Udo Hoffmann,et al.  Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits , 2011, PLoS genetics.

[47]  T. Okanoue,et al.  Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan , 2011, Journal of gastroenterology and hepatology.

[48]  V. de Lédinghen,et al.  Controlled attenuation parameter (CAP): a novel VCTE™ guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: preliminary study and validation in a cohort of patients with chronic liver disease from various causes. , 2010, Ultrasound in medicine & biology.

[49]  O. Cummings,et al.  Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. , 2010, Gastroenterology.

[50]  M. Stepanova,et al.  Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study , 2010, Gut.

[51]  Scott Harmsen,et al.  Nonalcoholic Fatty Liver Disease Increases Risk of Death Among Patients With Diabetes: A Community-Based Cohort Study , 2010, The American Journal of Gastroenterology.

[52]  A. Suzuki,et al.  Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease , 2010, Hepatology.

[53]  S. Popova,et al.  Social cost of heavy drinking and alcohol dependence in high-income countries , 2010, International Journal of Public Health.

[54]  J. Tuomilehto,et al.  Non-alcoholic and alcoholic Fatty Liver Disease - two Diseases of Affluence associated with the Metabolic Syndrome and Type 2 Diabetes: the FIN-D2D Survey , 2010, BMC public health.

[55]  Michael Krawczak,et al.  Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians , 2010, Hepatology.

[56]  J. Ahmad,et al.  Outcomes of liver transplantation in patients with cirrhosis due to nonalcoholic steatohepatitis versus patients with cirrhosis due to alcoholic liver disease , 2010, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[57]  Shelby Sullivan.  Implications of diet on nonalcoholic fatty liver disease , 2010, Current opinion in gastroenterology.

[58]  Julien Vergniol,et al.  Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease , 2010, Hepatology.

[59]  R. González-Sarmiento,et al.  Tumor necrosis factor polymorphisms and alcoholic liver disease: a HuGE review and meta-analysis. , 2009, American journal of epidemiology.

[60]  A. Sanyal,et al.  Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease. , 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[61]  K. Imanaka,et al.  Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis , 2009, Journal of Gastroenterology.

[62]  D. Malone,et al.  Health care utilization and costs by metabolic syndrome risk factors. , 2009, Metabolic syndrome and related disorders.

[63]  N. Sheron,et al.  Drinking patterns, dependency and life-time drinking history in alcohol-related liver disease. , 2009, Addiction.

[64]  Chunhong Bai,et al.  Long-term follow-up of patients with nonalcoholic fatty liver. , 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[65]  Katsutoshi Tokushige,et al.  Clinical features and outcomes of cirrhosis due to non‐alcoholic steatohepatitis compared with cirrhosis caused by chronic hepatitis C , 2009, Journal of gastroenterology and hepatology.

[66]  Y. Ngo,et al.  Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease , 2009, Hepatology.

[67]  D. Thabut,et al.  The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumption , 2009, European journal of gastroenterology & hepatology.

[68]  Per Christoffersen,et al.  Final results of a long-term, clinical follow-up in fatty liver patients , 2009, Scandinavian journal of gastroenterology.

[69]  Raj Vuppalanchi,et al.  Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management , 2009, Hepatology.

[70]  M. Ziol,et al.  Assessment of liver fibrosis using transient elastography in patients with alcoholic liver disease. , 2008, Journal of hepatology.

[71]  T. Kadowaki,et al.  Alcohol consumption and risk of type 2 diabetes mellitus in Japanese: a systematic review. , 2008, Asia Pacific journal of clinical nutrition.

[72]  L. Thygesen,et al.  Incidence of cardiovascular and cerebrovascular disease in Danish men and women with a prolonged heavy alcohol intake. , 2008, Alcoholism, clinical and experimental research.

[73]  Z. Younossi,et al.  Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease. , 2008, Journal of hepatology.

[74]  Alexander Pertsemlidis,et al.  Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease , 2008, Nature Genetics.

[75]  S. McCall,et al.  Fructose consumption as a risk factor for non-alcoholic fatty liver disease. , 2008, Journal of hepatology.

[76]  M. Omary,et al.  Epidemiology of alcohol-related liver and pancreatic disease in the United States. , 2008, Archives of internal medicine.

[77]  S. Piro,et al.  Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease. , 2008, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[78]  H. Seitz,et al.  Age, alcohol metabolism and liver disease , 2008, Current opinion in clinical nutrition and metabolic care.

[79]  Z. Halpern,et al.  Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study. , 2007, Journal of hepatology.

[80]  F. Stickel,et al.  Alcoholic liver disease in the elderly. , 2007, Clinics in geriatric medicine.

[81]  V. Cicinnati,et al.  Single-Center Experience on Liver Transplantation for Hepatocellular Carcinoma Arising in Alcoholic Cirrhosis: Results and Ethical Issues , 2007, European Surgical Research.

[82]  J. Trinchet,et al.  Fibrosis progression occurs in a subgroup of heavy drinkers with typical histological features , 2007, Alimentary pharmacology & therapeutics.

[83]  S. Sanderson,et al.  Utility of a new model to diagnose an alcohol basis for steatohepatitis. , 2006, Gastroenterology.

[84]  Jeffrey B. Schwimmer,et al.  Prevalence of Fatty Liver in Children and Adolescents , 2006, Pediatrics.

[85]  M. Holmqvist,et al.  Long‐term follow‐up of patients with NAFLD and elevated liver enzymes , 2006, Hepatology.

[86]  S. Commans,et al.  Characterization of the human patatin-like phospholipase familys⃞ Published, JLR Papers in Press, June 25, 2006. , 2006, Journal of Lipid Research.

[87]  J. Montaner,et al.  Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection , 2006, Hepatology.

[88]  Robert A Fisher,et al.  Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C , 2006, Hepatology.

[89]  V. de Lédinghen,et al.  Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease , 2006, BMC gastroenterology.

[90]  M. Miquel,et al.  Probability of liver cancer and survival in HCV‐related or alcoholic‐decompensated cirrhosis. A study of 377 patients , 2006, Liver international : official journal of the International Association for the Study of the Liver.

[91]  M. Soyka,et al.  Validity of carbohydrate-deficient transferrin (%CDT), gamma-glutamyltransferase (gamma-GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non-alcoholic and alcoholic origin. , 2005, Addiction.

[92]  Shi-yao Chen,et al.  Prevalence of and risk factors for fatty liver in a general population of Shanghai, China. , 2005, Journal of hepatology.

[93]  S. Sanderson,et al.  The natural history of nonalcoholic fatty liver disease: a population-based cohort study. , 2005, Gastroenterology.

[94]  T. Giles,et al.  Alcohol and the cardiovascular system: research challenges and opportunities. , 2005, Journal of the American College of Cardiology.

[95]  P. Miller,et al.  Excessive Alcohol Consumption and Hypertension: Clinical Implications of Current Research , 2005, Journal of clinical hypertension.

[96]  O. Cummings,et al.  Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.

[97]  D. Thabut,et al.  Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[98]  J. Freudenheim,et al.  Greater hepatic vulnerability after alcohol intake in African Americans compared with Caucasians: a population-based study. , 2004, Journal of the National Medical Association.

[99]  A. McCullough,et al.  The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. , 2004, Clinics in liver disease.

[100]  K. Hasegawa,et al.  Comparison of hepatocellular carcinoma patients with alcoholic liver disease and nonalcoholic steatohepatitis. , 2004, Alcoholism, clinical and experimental research.

[101]  J. Jahnsen,et al.  Long‐term prognosis of patients with alcoholic liver cirrhosis: a 15‐year follow‐up study of 100 Norwegian patients admitted to one unit , 2004, Scandinavian journal of gastroenterology.

[102]  J. Kalbfleisch,et al.  A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C , 2003, Hepatology.

[103]  Jian-Gao Fan,et al.  Prevalence of nonalcoholic fatty liver among administrative officers in Shanghai: an epidemiological survey. , 2003, World journal of gastroenterology.

[104]  G. Marchesini,et al.  Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome , 2003, Hepatology.

[105]  B. Cooper,et al.  Ethnic differences in cirrhosis of the liver in a British city: alcoholic cirrhosis in South Asian men. , 2003, Alcohol and alcoholism.

[106]  R. D'Agostino,et al.  Alcohol Consumption and Risk of Ischemic Stroke: The Framingham Study , 2002, Stroke.

[107]  P. Bedossa,et al.  Risk factors of fibrosis in alcohol‐induced liver disease , 2002, Hepatology.

[108]  J. Dixon,et al.  Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. , 2001, Gastroenterology.

[109]  K. Tatara,et al.  Alcohol consumption and risk for hypertension in middle-aged Japanese men , 2001, Journal of hypertension.

[110]  T. Poynard,et al.  Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study , 2001, The Lancet.

[111]  P. Gruenewald,et al.  Beverage-specific alcohol consumption and cirrhosis mortality in a group of English-speaking beer-drinking countries. , 2000, Addiction.

[112]  B. Neuschwander‐Tetri,et al.  Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions , 1999, American Journal of Gastroenterology.

[113]  G. Brandi,et al.  Drinking habits as cofactors of risk for alcohol induced liver damage , 1997, Gut.

[114]  F. Capron,et al.  Excess weight risk factor for alcoholic liver disease , 1997, Hepatology.

[115]  T. Sørensen,et al.  Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study , 1996, Hepatology.

[116]  Z. Yuan,et al.  Alcohol-related hospitalizations of elderly people. Prevalence and geographic variation in the United States. , 1993, JAMA.

[117]  A. Belanger,et al.  The Framingham study. , 1976, British medical journal.

[118]  M. Taniai,et al.  Hepatic and extrahepatic malignancies in cirrhosis caused by nonalcoholic steatohepatitis and alcoholic liver disease. , 2013, Alcoholism, clinical and experimental research.

[119]  B. Gersh.  National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants , 2012 .

[120]  R. Brůha,et al.  Alcoholic liver disease. , 2012, World journal of hepatology.

[121]  Joel Z Stengel,et al.  Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. , 2011, Gastroenterology.

[122]  S. Smallbone,et al.  Outcomes of , 2010 .

[123]  David Kershenobich,et al.  Variant in PNPLA3 is associated with alcoholic liver disease , 2010, Nature Genetics.

[124]  Tetsuji Sato,et al.  The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. , 2006, Annals of internal medicine.

[125]  S. Sanderson,et al.  The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. , 2005, Journal of hepatology.

[126]  H. Minuk,et al.  Metabolic syndrome. , 2005, Journal of insurance medicine.

[127]  Shohei Matsuzaki,et al.  Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background , 2003, Journal of Gastroenterology.

[128]  S. Stewart.  Racial and ethnic differences in alcohol-associated aspartate aminotransferase and gamma-glutamyltransferase elevation. , 2002, Archives of internal medicine.

[129]  A. Chlumská,et al.  [Alcoholic hepatitis]. , 1987, Casopis lekaru ceskych.

[130]  F. Schaffner,et al.  Nonalcoholic fatty liver disease. , 1986, Progress in liver diseases.