Effect of nanocavity confinement on the rotational relaxation dynamics: 3-acetyl-4-oxo-6,7-dihydro-12H indolo-[2,3-a] quinolizine in micelles.

In continuation of our recent study on the steady state photophysics of a biologically active beta-carboline derivative, 3-acetyl-4-oxo-6,7-dihydro-12H indolo-[2,3-a] quinolizine (AODIQ), in the present article we have investigated the effect of nanocavity confinement on the excited state dynamics and rotational relaxation of the probe using picosecond time resolved fluorescence and fluorescence anisotropy techniques. The polarity dependent intramolecular charge transfer process is responsible for the remarkable sensitivity of this biological fluorophore in micellar environments. The fluorescence anisotropy decay of AODIQ incorporated inside the micelle is biexponential. The rotational motion of the probe was interpreted on the basis of a two step model consisting of a fast restricted rotation of the probe and a slow lateral diffusion of the probe in the micelle; both coupled to the overall rotation of the micelle. Experimental results reveal that micellar environment causes significant retardation of both the wobbling as well as the translational motion of the probe.

[1]  A. Chakraborty,et al.  Photoinduced electron transfer from N,N-dimethylaniline to 7-amino coumarins in protein-surfactant complex: slowing down of electron transfer dynamics compared to micelles. , 2006, The Journal of chemical physics.

[2]  Arabinda Mallick,et al.  Surfactant-induced modulation of fluorosensor activity: a simple way to maximize the sensor efficiency. , 2006, Journal of the American Chemical Society.

[3]  Arabinda Mallick,et al.  Spectroscopic investigation on the interaction of ICT probe 3-acetyl-4-oxo-6,7-dihydro-12H Indolo-[2,3-a] quinolizine with serum albumins. , 2005, The journal of physical chemistry. B.

[4]  A. Chakraborty,et al.  Effect of alkyl chain length and size of the headgroups of the surfactant on solvent and rotational relaxation of Coumarin 480 in micelles and mixed micelles. , 2005, The Journal of chemical physics.

[5]  M. Fayer,et al.  Orientational dynamics of water confined on a nanometer length scale in reverse micelles. , 2005, The Journal of chemical physics.

[6]  Arabinda Mallick,et al.  Constrained photophysics of 3-acetyl-4-oxo-6,7-dihydro-12H indolo-[2,3-a] quinolizine in micellar environments: a spectrofluorometric study. , 2004, Journal of colloid and interface science.

[7]  M. Kumbhakar,et al.  Solvation dynamics in triton-X-100 and triton-X-165 micelles: effect of micellar size and hydration. , 2004, The Journal of chemical physics.

[8]  S. Ghosh,et al.  Interaction of 3,7-diamino-2,8-dimethyl-5-phenyl phenazinium chloride with model biological membranes and reverse micelles of lipid: a spectroscopic study. , 2004, Chemistry and physics of lipids.

[9]  Arabinda Mallick,et al.  Photophysics of norharmane in micellar environments: a fluorometric study. , 2004, Biophysical chemistry.

[10]  G. Dutt.  Are the Experimentally Determined Microviscosities of the Micelles Probe Dependent , 2004 .

[11]  G. Dutt.  Rotational Relaxation of Hydrophobic Probes in Nonionic Reverse Micelles: Influence of Water Content on the Location and Mobility of the Probe Molecules , 2004 .

[12]  G. Dutt.  Rotational Diffusion of Hydrophobic Probes in Brij-35 Micelles: Effect of Temperature on Micellar Internal Environment , 2003 .

[13]  Arabinda Mallick,et al.  Photophysics of 3-acetyl-4-oxo-6,7-dihydro-12H indolo-[2,3-a] quinolizine: emission from two states , 2003 .

[14]  G. Dutt.  Rotational relaxation of nondipolar probes in triton X-100 micelles in the presence of added salt: Correlation of lateral diffusion coefficient with dry micelle radius , 2003 .

[15]  B. Sengupta,et al.  Binding of quercetin with human serum albumin: a critical spectroscopic study. , 2003, Biopolymers.

[16]  P. Hazra,et al.  Intramolecular Charge Transfer and Solvation Dynamics of Coumarin 152 in Aerosol-OT, Water-Solubilizing Reverse Micelles, and Polar Organic Solvent Solubilizing Reverse Micelles , 2002 .

[17]  K. Bhattacharyya,et al.  Fluorescence Anisotropy Decay in Polymer−Surfactant Aggregates , 2001 .

[18]  B. Sengupta,et al.  Influence of reverse micellar environments on the fluorescence emission properties of tryptophan octyl ester. , 2000, Biochemical and biophysical research communications.

[19]  S. Stolc,et al.  Indole derivatives as neuroprotectants. , 1999, Life sciences.

[20]  N. Maiti,et al.  Fluorescence Dynamics of Dye Probes in Micelles , 1997 .

[21]  S. Maity,et al.  Twisted intramolecular charge transfer of dimethylaminobenzonitrile in micellar environments a way to look at the orientation of the probe within the apolar microenvironment , 1997 .

[22]  R. Becker,et al.  β-Carbolines. 2. Rate Constants of Proton Transfer from Multiexponential Decays in the Lowest Singlet Excited State of Harmine in Water As a Function of pH , 1996 .

[23]  K. Bhattacharyya,et al.  Solvation Dynamics of Coumarin 480 in Micelles , 1996 .

[24]  R. Becker,et al.  .beta.-Carboline Photosensitizers. 3. Studies on Ground and Excited State Partitioning in AOT/Water/Cyclohexane Microemulsions , 1995 .

[25]  G. W. Robinson,et al.  TIME- AND SPACE-RESOLVED STUDIES OF THE PHYSICS AND CHEMISTRY OF LIQUID WATER NEAR A BIOLOGICALLY RELEVANT INTERFACE , 1995 .

[26]  M. Fayer,et al.  Dynamics of ionic lipophilic probes in micelles: Picosecond fluorescence depolarization measurements , 1993 .

[27]  J. Svobodová,et al.  Fluorescence decay and depolarization in membranes , 1992 .

[28]  M. Wirth,et al.  Frequency-domain spectroscopic study of the effect of n-propanol on the internal viscosity of sodium dodecyl sulfate micelles , 1991 .

[29]  N. Chattopadhyay,et al.  An excited state proton transfer reaction in micellar media , 1989 .

[30]  O. Soederman,et al.  Surfactant dynamics in spherical and nonspherical micelles. A nuclear magnetic resonance study , 1986 .

[31]  Graham R. Fleming,et al.  Chemical applications of ultrafast spectroscopy , 1986 .

[32]  B. Maiti,et al.  Convenient synthesis of 6,7-dihydroflavopereirine and flavopereirine , 1984 .

[33]  C. Hjelm,et al.  Carbon-13 nuclear magnetic resonance relaxation in microemulsions. Aggregation in the extensive solution phase of the sodium octanoate-octanoic acid-water system , 1983 .

[34]  J. Lakowicz.  Principles of fluorescence spectroscopy , 1983 .

[35]  A. Szabó,et al.  Effect of librational motion on fluorescence depolarization and nuclear magnetic resonance relaxation in macromolecules and membranes. , 1980, Biophysical journal.

[36]  J. K. Thomas,et al.  Kinetic studies in bile acid micelles. , 1975, Journal of the American Chemical Society.

[37]  Janos H. Fendler,et al.  Catalysis in micellar and macromolecular systems , 1975 .

[38]  J. Demas,et al.  Measurement of photoluminescence quantum yields. Review , 1971 .