Hydrogels for biomedical applications.

Hydrogels are swollen, crosslinked networks that have great potential for use in biomedicine. Their softness, biocompatibility and ability for rapid diffusion of molecules make them useful for drug delivery, cell culture, wound healing and sensing applications. The chemical functionality of the gels can be easily modified to provide signalling and growth factors for cell proliferation. To allow the ingress of large cells, either porosity of the substrate can be controlled, or the gel can be made biodegradable. One ultimate goal is the growth of entire organs in the laboratory for eventual transplantation. Gels can be used as drug-delivery vehicles, either as implantable depots, or as microgels in blood-based delivery systems. One expanding area is the use of gels as surgical aides to prevent bleeding, infection and post-operative complications.

[1]  Jing Peng,et al.  Radiation synthesis of PVP/CMC hydrogels as wound dressing , 2007 .

[2]  K. Pal,et al.  Polymeric Hydrogels: Characterization and Biomedical Applications , 2009 .

[3]  M. Rabau,et al.  Free pleuroperitoneal liquid movement indicating diaphragmatic tear. , 1985, Injury.

[4]  D. Pochan,et al.  Inherent Antibacterial Activity of a Peptide-Based β-Hairpin Hydrogel , 2007 .

[5]  David Putnam,et al.  Design of an injectable synthetic and biodegradable surgical biomaterial , 2010, Proceedings of the National Academy of Sciences.

[6]  Jiajie Yu,et al.  Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model. , 2011, Lab on a chip.

[7]  H. Fujioka,et al.  Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells. , 2007, Osteoarthritis and cartilage.

[8]  A Montembault,et al.  A material decoy of biological media based on chitosan physical hydrogels: application to cartilage tissue engineering. , 2006, Biochimie.

[9]  M. Shoichet,et al.  Biomaterials for Brain Tissue Engineering , 2010 .

[10]  Michelle C LaPlaca,et al.  Thermoreversible laminin-functionalized hydrogel for neural tissue engineering. , 2006, Journal of biomedical materials research. Part A.

[11]  Samah Benamer,et al.  Synthesis and characterisation of hydrogels based on poly(vinyl pyrrolidone) , 2006 .

[12]  C. Colton,et al.  Implantable biohybrid artificial organs. , 1995, Cell transplantation.

[13]  Vladimir Mironov,et al.  Organ printing: computer-aided jet-based 3D tissue engineering. , 2003, Trends in biotechnology.

[14]  Anthony Guiseppi-Elie,et al.  Electroconductive hydrogels: synthesis, characterization and biomedical applications. , 2010, Biomaterials.

[15]  D. Kohane,et al.  Polymers in the prevention of peritoneal adhesions. , 2008, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[16]  S. Gerecht,et al.  Functional neovascularization of biodegradable dextran hydrogels with multiple angiogenic growth factors. , 2011, Biomaterials.

[17]  R. Bretzel,et al.  Polymers for Induction of Revascularization in the Rat Fascial Flap: Application of Vascular Endothelial Growth Factor and Pancreatic Islet Cells , 2003, Cell transplantation.

[18]  S. Moratti,et al.  The Efficacy of a Novel Chitosan Gel on Hemostasis and Wound Healing after Endoscopic Sinus Surgery , 2010, American journal of rhinology & allergy.

[19]  Andrés J. García,et al.  Bioartificial matrices for therapeutic vascularization , 2009, Proceedings of the National Academy of Sciences.

[20]  Qi Li,et al.  A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[21]  R. Marchant,et al.  Design and synthesis of biomimetic hydrogel scaffolds with controlled organization of cyclic RGD peptides. , 2009, Bioconjugate chemistry.

[22]  Jos Malda,et al.  Strategies for zonal cartilage repair using hydrogels. , 2009, Macromolecular bioscience.

[23]  Kristi S Anseth,et al.  Cell–cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing β-cell function , 2011, Proceedings of the National Academy of Sciences.

[24]  Yi Yan Yang,et al.  Biomimetic hydrogels for chondrogenic differentiation of human mesenchymal stem cells to neocartilage. , 2010, Biomaterials.

[25]  N. Mohan,et al.  Polyvinyl alcohol-poly(caprolactone) semi IPN scaffold with implication for cartilage tissue engineering. , 2008, Journal of biomedical materials research. Part B, Applied biomaterials.

[26]  Jason P. Gleghorn,et al.  Microfluidic scaffolds for tissue engineering. , 2007, Nature materials.

[27]  Y. Tabata,et al.  Growth factor-mediated effects on chondrogenic differentiation of mesenchymal stem cells in 3D semi-IPN poly(vinyl alcohol)-poly(caprolactone) scaffolds. , 2010, Journal of biomedical materials research. Part A.

[28]  R. Bellamkonda,et al.  Biomaterials for the central nervous system , 2008, Journal of The Royal Society Interface.

[29]  Nic D. Leipzig,et al.  Differentiation of neural stem cells in three-dimensional growth factor-immobilized chitosan hydrogel scaffolds. , 2011, Biomaterials.

[30]  Tessa Lühmann,et al.  Cell Guidance by 3D-Gradients in Hydrogel Matrices: Importance for Biomedical Applications , 2009, Materials.

[31]  Dietmar W. Hutmacher,et al.  Long-term effects of hydrogel properties on human chondrocyte behavior , 2010 .

[32]  Long Zhao,et al.  Synthesis of pH-sensitive PVP/CM-chitosan hydrogels with improved surface property by irradiation , 2006 .

[33]  Dongan Wang,et al.  Chondrogenesis of Synovium-Derived Mesenchymal Stem Cells in Photopolymerizing Hydrogel Scaffolds , 2010, Journal of biomaterials science. Polymer edition.

[34]  S. Mandy.  A new primary wound dressing made of polyethylene oxide gel. , 1983, The Journal of dermatologic surgery and oncology.

[35]  Shantikumar V. Nair,et al.  Preparation and characterization of novel β-chitin/nanosilver composite scaffolds for wound dressing applications , 2010 .

[36]  R. Eavey,et al.  Tissue engineered cartilage "bioshell" protective layer for subcutaneous implants. , 2007, International journal of pediatric otorhinolaryngology.

[37]  Reuben T Chacko,et al.  Self-cross-linked polymer nanogels: a versatile nanoscopic drug delivery platform. , 2010, Journal of the American Chemical Society.

[38]  J. West,et al.  A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[39]  M. Fussenegger,et al.  Drug-sensing hydrogels for the inducible release of biopharmaceuticals. , 2008, Nature materials.

[40]  M Fini,et al.  Hyaluronic acid hydrogel in the treatment of osteoarthritis. , 2002, Biomaterials.

[41]  Andre Levchenko,et al.  Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs , 2009, Proceedings of the National Academy of Sciences.

[42]  B. Sreedhar,et al.  Hydrogel–silver nanoparticle composites: A new generation of antimicrobials† , 2010 .

[43]  H. Brøndsted,et al.  Hydrogels for site-specific oral drug delivery: synthesis and characterization. , 1991, Biomaterials.

[44]  J. Richie,et al.  Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Olivier De Wever,et al.  Growth factor modulation of fibroblast proliferation, differentiation, and invasion: implications for tissue valve engineering. , 2006, Tissue engineering.

[46]  R. Barbucci,et al.  Hyaluronic acid hydrogel added with ibuprofen-lysine for the local treatment of chondral lesions in the knee: in vitro and in vivo investigations. , 2005, Journal of biomedical materials research. Part B, Applied biomaterials.

[47]  Jerry C. Hu,et al.  Low-density cultures of bovine chondrocytes: effects of scaffold material and culture system. , 2005, Biomaterials.

[48]  Bing Xu,et al.  Molecular nanofibers of olsalazine form supramolecular hydrogels for reductive release of an anti-inflammatory agent. , 2010, Journal of the American Chemical Society.

[49]  J. Wilkins,et al.  Clinical experience with an antimicrobial hydrogel dressing on recalcitrant wounds. , 2010, Journal of wound care.

[50]  R. Barbucci,et al.  An amidated carboxymethylcellulose hydrogel for cartilage regeneration , 2008, Journal of materials science. Materials in medicine.

[51]  K. Kataoka,et al.  Biodegradable nanogels prepared by atom transfer radical polymerization as potential drug delivery carriers: synthesis, biodegradation, in vitro release, and bioconjugation. , 2007, Journal of the American Chemical Society.

[52]  T. Aigner,et al.  Transplantation of allograft chondrocytes embedded in agarose gel into cartilage defects of rabbits. , 1998, Osteoarthritis and cartilage.

[53]  J. Burdick,et al.  Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels. , 2009, Osteoarthritis and cartilage.

[54]  M. Yarmush,et al.  A novel formulation of oxygen‐carrying matrix enhances liver‐specific function of cultured hepatocytes , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[55]  S. Bhatia,et al.  Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[56]  A. Kabanov,et al.  Polyplex Nanogel formulations for drug delivery of cytotoxic nucleoside analogs. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[57]  Liang Zhao,et al.  An injectable calcium phosphate-alginate hydrogel-umbilical cord mesenchymal stem cell paste for bone tissue engineering. , 2010, Biomaterials.

[58]  Shoji Takeuchi,et al.  Injectable hydrogel microbeads for fluorescence-based in vivo continuous glucose monitoring , 2010, Proceedings of the National Academy of Sciences.

[59]  P. Benya,et al.  Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels , 1982, Cell.

[60]  Suna Choi,et al.  Control of Blood Glucose by Novel GLP-1 Delivery Using Biodegradable Triblock Copolymer of PLGA-PEG-PLGA in Type 2 Diabetic Rats , 2004, Pharmaceutical Research.

[61]  Glenn D Prestwich,et al.  Osteochondral defect repair with autologous bone marrow-derived mesenchymal stem cells in an injectable, in situ, cross-linked synthetic extracellular matrix. , 2006, Tissue engineering.

[62]  P. Campbell,et al.  Evaluation of the SprayGel adhesion barrier in the rat cecum abrasion and rabbit uterine horn adhesion models. , 2001, Fertility and sterility.

[63]  K. Fowers,et al.  OncoGel (ReGel/paclitaxel)--clinical applications for a novel paclitaxel delivery system. , 2009, Advanced drug delivery reviews.

[64]  Kristi S Anseth,et al.  Three-dimensional biochemical patterning of click-based composite hydrogels via thiolene photopolymerization. , 2008, Biomacromolecules.

[65]  M. Shoichet,et al.  Design of biomaterials to enhance stem cell survival when transplanted into the damaged central nervous system , 2010 .

[66]  O. Wichterle,et al.  Hydrophilic Gels for Biological Use , 1960, Nature.

[67]  Nic D. Leipzig,et al.  Functional immobilization of interferon-gamma induces neuronal differentiation of neural stem cells. , 2009, Journal of biomedical materials research. Part A.

[68]  Robert Langer,et al.  Antifungal hydrogels , 2007, Proceedings of the National Academy of Sciences.

[69]  Jingping Liu,et al.  Self-assembly-peptide hydrogels as tissue-engineering scaffolds for three-dimensional culture of chondrocytes in vitro. , 2010, Macromolecular bioscience.

[70]  A. Khademhosseini,et al.  A cell-laden microfluidic hydrogel. , 2007, Lab on a chip.

[71]  M. C. Rowland,et al.  Photolithographic patterning of polyethylene glycol hydrogels. , 2006, Biomaterials.

[72]  P. Sáha,et al.  Development and Characterization of Novel Medicated Hydrogels for Wound Dressing , 2010 .

[73]  Michael S Detamore,et al.  Hierarchically designed agarose and poly(ethylene glycol) interpenetrating network hydrogels for cartilage tissue engineering. , 2010, Tissue engineering. Part C, Methods.

[74]  Robert P Keatch,et al.  Engineering the bone-ligament interface using polyethylene glycol diacrylate incorporated with hydroxyapatite. , 2009, Tissue engineering. Part A.

[75]  R. Eavey,et al.  Engineering Autogenous Cartilage in the Shape of a Helix Using an Injectable Hydrogel Scaffold , 2000, The Laryngoscope.

[76]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[77]  D. Görlich,et al.  A Saturated FG-Repeat Hydrogel Can Reproduce the Permeability Properties of Nuclear Pore Complexes , 2007, Cell.

[78]  Glenn D Prestwich,et al.  Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering. , 2006, Journal of biomedical materials research. Part A.

[79]  D. Kohane,et al.  HYDROGELS IN DRUG DELIVERY: PROGRESS AND CHALLENGES , 2008 .

[80]  Kristi S. Anseth,et al.  Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties , 2009, Science.

[81]  Joe Tien,et al.  Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element. , 2007, Lab on a chip.

[82]  Alexander V Kabanov,et al.  Nanogels for oligonucleotide delivery to the brain. , 2004, Bioconjugate chemistry.

[83]  J. Lee,et al.  Wound healing evaluation of sodium fucidate-loaded polyvinylalcohol/sodium carboxymethylcellulose-based wound dressing , 2010, Archives of pharmacal research.

[84]  S. Cartmell,et al.  The composition of hydrogels for cartilage tissue engineering can influence glycosaminoglycan profile. , 2010, European cells & materials.

[85]  Jennifer L West,et al.  Design and characterization of poly(ethylene glycol) photopolymerizable semi-interpenetrating networks for chondrogenesis of human mesenchymal stem cells. , 2007, Tissue engineering.

[86]  S. Varghese,et al.  Influence of Physical Properties of Biomaterials on Cellular Behavior , 2011, Pharmaceutical Research.

[87]  Jong Hwan Sung,et al.  A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. , 2009, Lab on a chip.

[88]  D. Pochan,et al.  Injectable solid hydrogel: mechanism of shear-thinning and immediate recovery of injectable β-hairpin peptide hydrogels. , 2010, Soft matter.

[89]  J. Boateng,et al.  Wound healing dressings and drug delivery systems: a review. , 2008, Journal of pharmaceutical sciences.

[90]  Matthew Pilarz,et al.  Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells , 2007, Proceedings of the National Academy of Sciences.

[91]  Robert Langer,et al.  Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells , 2007, Proceedings of the National Academy of Sciences.

[92]  N. Cho,et al.  Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability , 2010, Proceedings of the National Academy of Sciences.

[93]  H. Maeda,et al.  Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[94]  A. Metters,et al.  Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[95]  David J Mooney,et al.  An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects. , 2011, Biomaterials.

[96]  S. Stapley,et al.  Debridement of diabetic foot ulcers. , 2010, The Cochrane database of systematic reviews.

[97]  K. Anseth,et al.  Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells. , 2008, Nature materials.

[98]  P. Robins,et al.  The effect of two new dressings on epidermal wound healing. , 1982, The Journal of dermatologic surgery and oncology.

[99]  J. Paul Robinson,et al.  A novel and simple cell-based detection system with a collagen-encapsulated B-lymphocyte cell line as a biosensor for rapid detection of pathogens and toxins , 2008, Laboratory Investigation.

[100]  Shuguang Zhang,et al.  Controlled release of functional proteins through designer self-assembling peptide nanofiber hydrogel scaffold , 2009, Proceedings of the National Academy of Sciences.

[101]  F. Grippaudo,et al.  Procutase versus 1% silver sulphadiazine in the treatment of minor burns. , 2010, Burns : journal of the International Society for Burn Injuries.

[102]  D. W. Yates,et al.  Clinical experience with a new hydrogel wound dressing. , 1984, Injury.

[103]  Tony M. Kuriger,et al.  Synthesis and Characterization of Chitosan/ Dextran‐Based Hydrogels for Surgical Use , 2009 .

[104]  BanuPriya Sridharan,et al.  Living Bacterial Sacrificial Porogens to Engineer Decellularized Porous Scaffolds , 2011, PloS one.

[105]  Hinrich Wiese,et al.  In vitro and in vivo cartilage engineering using a combination of chondrocyte-seeded long-term stable fibrin gels and polycaprolactone-based polyurethane scaffolds. , 2007, Tissue engineering.

[106]  S. Hollister,et al.  Tissue engineering of the synovial joint: The role of cell density , 2007, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[107]  O. Higa,et al.  Biocompatibility study for PVP wound dressing obtained in different conditions , 1999 .

[108]  G. Prestwich,et al.  Synthesis, characterization and chondroprotective properties of a hyaluronan thioethyl ether derivative. , 2008, Biomaterials.