The influence of oestrone on the production of tumour necrosis factor by human peripheral blood adherent cells.

Human peripheral blood adherent cells (PBAC) incubated with oestrone in high concentration (10(-5) M) release, on exposure to bacterial endotoxin, an amount of tumour necrosis factor (TNF) greater than do cells incubated without the steroid. The finding may imply a non-endocrine hormonal process leading to heightened local TNF responses. This may be the basis of endotoxin hypersensitivity in pregnancy.

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