Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy.
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Dmitri Artemov | Zaver M Bhujwalla | Z. Bhujwalla | Cong Li | Marie-France Penet | F. Wildes | T. Takagi | Zhihang Chen | P. Winnard | D. Artemov | Marie-France Penet | Cong Li | Flonné Wildes | Tomoyo Takagi | Zhihang Chen | Paul T Winnard
[1] Z. Bhujwalla,et al. Conjugation of poly-L-lysine to bacterial cytosine deaminase improves the efficacy of enzyme/prodrug cancer therapy. , 2008, Journal of medicinal chemistry.
[2] Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer. , 2010, Chemical reviews.
[3] G. Tozer,et al. From bench to bedside for gene-directed enzyme prodrug therapy of cancer. , 2005, Anti-cancer drugs.
[4] H. Hondermarck,et al. Production of sulfated proteoglycans by human breast cancer cell lines: Binding to fibroblast growth factor‐2 , 1997, Journal of cellular biochemistry.
[5] R. Lenkinski,et al. Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions. , 2002, Journal of the National Cancer Institute.
[6] Dai Fukumura,et al. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. , 2007, Microvascular research.
[7] D. Gowda,et al. Isolation and characterization of proteoglycans secreted by normal and malignant human mammary epithelial cells. , 1986, The Journal of biological chemistry.
[8] R K Jain,et al. Transport of molecules in the tumor interstitium: a review. , 1987, Cancer research.
[9] Z. Bhujwalla,et al. Image-Guided Enzyme/Prodrug Cancer Therapy , 2008, Clinical Cancer Research.
[10] W. Hull,et al. Fluoropyrimidine chemotherapy in a rat model: comparison of fluorouracil metabolite profiles determined by high‐field 19F‐NMR spectroscopy of tissues ex vivo with therapy response and toxicity for locoregional vs systemic infusion protocols , 2004, NMR in biomedicine.
[11] T. Park,et al. Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. , 2008, Journal of controlled release : official journal of the Controlled Release Society.
[12] J. Coll,et al. Side‐effects of a systemic injection of linear polyethylenimine–DNA complexes , 2002, The journal of gene medicine.
[13] D. Gowda,et al. Structures of O-linked oligosaccharides present in the proteoglycans secreted by human mammary epithelial cells. , 1986, The Journal of biological chemistry.
[14] Bradford A Moffat,et al. The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.
[15] P. Russell,et al. Novel gene-directed enzyme prodrug therapies against prostate cancer , 2006, Expert opinion on investigational drugs.
[16] Daniel B Vigneron,et al. In vivo molecular imaging for planning radiation therapy of gliomas: An application of 1H MRSI , 2002, Journal of magnetic resonance imaging : JMRI.
[17] V. Raman,et al. Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells. , 2007, Cancer research.
[18] J. Lacal,et al. Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells , 2003, Oncogene.
[19] Khaled Greish,et al. Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines , 2007, Journal of drug targeting.
[20] H. McLeod,et al. Strategies for enzyme/prodrug cancer therapy. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[21] Clive J Roberts,et al. Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system. , 2002, Bioconjugate chemistry.
[22] V. Raman,et al. RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation. , 2005, Cancer research.
[23] Ellen Ackerstaff,et al. Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions. , 2006, Molecular pharmaceutics.
[24] J. Lacal,et al. Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action , 2004, Oncogene.
[25] T. Tuschl,et al. Mechanisms of gene silencing by double-stranded RNA , 2004, Nature.
[26] Jose M. Silva,et al. Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy , 2002, Oncogene.
[27] Jonathan R Nebeker,et al. Dissemination of information on potentially fatal adverse drug reactions for cancer drugs from 2000 to 2002: first results from the research on adverse drug events and reports project. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[28] D Artemov,et al. Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA , 2009, Cancer Gene Therapy.
[29] M. Jacobs,et al. Choline metabolism in cancer: implications for diagnosis and therapy , 2006, Expert review of molecular diagnostics.
[30] Anna Moore,et al. In vivo imaging of siRNA delivery and silencing in tumors , 2007, Nature Medicine.
[31] G. Devi,et al. siRNA-based approaches in cancer therapy , 2006, Cancer Gene Therapy.
[32] P. Johnston,et al. 5-Fluorouracil: mechanisms of action and clinical strategies , 2003, Nature Reviews Cancer.
[33] A. Ramírez de Molina,et al. Differential Role of Human Choline Kinase α and β Enzymes in Lipid Metabolism: Implications in Cancer Onset and Treatment , 2009, PloS one.
[34] Z. Bhujwalla,et al. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. , 1999, Cancer research.
[35] D. Scherman,et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[36] A. Fire,et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans , 1998, Nature.
[37] F. Podo. Tumour phospholipid metabolism , 1999, NMR in biomedicine.
[38] Gerry McDermott,et al. The structure of Escherichia coli cytosine deaminase. , 2002, Journal of molecular biology.
[39] S. Goodman,et al. RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. , 2008, Cancer research.
[40] W. Negendank,et al. Studies of human tumors by MRS: A review , 1992, NMR in biomedicine.
[41] P. Stratta,et al. Gadolinium-enhanced magnetic resonance imaging, renal failure and nephrogenic systemic fibrosis/nephrogenic fibrosing dermopathy. , 2008, Current medicinal chemistry.
[42] R. Rosell,et al. Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. , 2002, Biochemical and biophysical research communications.
[43] B. Krishnamachary,et al. Applications of molecular MRI and optical imaging in cancer. , 2010, Future medicinal chemistry.
[44] B. Hillner,et al. Frequency and Cost of Chemotherapy-Related Serious Adverse Effects in a Population Sample of Women With Breast Cancer , 2007 .
[45] C. Richards,et al. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. , 1994, Proceedings of the National Academy of Sciences of the United States of America.