Risk factors of radiotherapy‐induced cerebral microbleeds and serial analysis of their size compared with white matter changes: A 7T MRI study in 113 adult patients with brain tumors

Although radiation therapy (RT) contributes to survival benefit in many brain tumor patients, it has also been associated with long‐term brain injury. Cerebral microbleeds (CMBs) represent an important manifestation of radiation‐related injury.

[1]  G. Bauman,et al.  Initial Investigation into Microbleeds and White Matter Signal Changes following Radiotherapy for Low-Grade and Benign Brain Tumors Using Ultra-High-Field MRI Techniques , 2017, American Journal of Neuroradiology.

[2]  Wenli Hu,et al.  The significant effects of cerebral microbleeds on cognitive dysfunction: An updated meta-analysis , 2017, PloS one.

[3]  Natalie L. Voets,et al.  Early detection of cerebral microbleeds following traumatic brain injury using MRI in the hyper-acute phase , 2017, Neuroscience Letters.

[4]  J. Kassubek,et al.  Cerebral Microstructural Alterations after Radiation Therapy in High-Grade Glioma: A Diffusion Tensor Imaging-Based Study , 2017, Front. Neurol..

[5]  Arthur F. Kramer,et al.  White Matter Integrity Declined Over 6-Months, but Dance Intervention Improved Integrity of the Fornix of Older Adults , 2017, Front. Aging Neurosci..

[6]  H. Shih,et al.  Evolution of cerebral microbleeds after cranial irradiation in medulloblastoma patients , 2017, Neurology.

[7]  Nico Bunzeck,et al.  Reward Dependent Invigoration Relates to Theta Oscillations and Is Predicted by Dopaminergic Midbrain Integrity in Healthy Elderly , 2017, Front. Aging Neurosci..

[8]  Susan M. Chang,et al.  Relationship between radiation dose and microbleed formation in patients with malignant glioma , 2016, Radiation Oncology.

[9]  J. Lupo,et al.  RO-02CEREBRAL MICROBLEEDS ARE ASSOCIATED WITH WORSE EXECUTIVE FUNCTION IN PEDIATRIC BRAIN TUMOR SURVIVORS , 2016 .

[10]  J. Maruya,et al.  Transient disappearance of microbleeds in the subacute period based on T2*-weighted gradient echo imaging in traumatic brain injury , 2016, Acta Neurochirurgica.

[11]  Walter J. Curran,et al.  Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma. , 2016, The New England journal of medicine.

[12]  B. M. ter Haar Romeny,et al.  Automated detection of cerebral microbleeds in patients with Traumatic Brain Injury , 2016, NeuroImage: Clinical.

[13]  Wei Liu,et al.  Imaging Cerebral Microhemorrhages in Military Service Members with Chronic Traumatic Brain Injury. , 2016, Radiology.

[14]  Susan M. Chang,et al.  Clinically feasible NODDI characterization of glioma using multiband EPI at 7 T , 2015, NeuroImage: Clinical.

[15]  Susan M. Chang,et al.  Simultaneous imaging of radiation‐induced cerebral microbleeds, arteries and veins, using a multiple gradient echo sequence at 7 Tesla , 2015, Journal of magnetic resonance imaging : JMRI.

[16]  Atle Bjørnerud,et al.  Serial diffusion tensor imaging for early detection of radiation‐induced injuries to normal‐appearing white matter in high‐grade glioma patients , 2015, Journal of magnetic resonance imaging : JMRI.

[17]  Christopher P. Hess,et al.  Susceptibility-weighted MR imaging of radiation therapy-induced cerebral microbleeds in patients with glioma: a comparison between 3T and 7T , 2014, Neuroradiology.

[18]  K. Yeom,et al.  Increased focal hemosiderin deposition in pediatric medulloblastoma patients receiving radiotherapy at a later age. , 2013, Journal of neurosurgery. Pediatrics.

[19]  A. Hasso,et al.  Neuroimaging Findings of the Post-Treatment Effects of Radiation and Chemotherapy of Malignant Primary Glial Neoplasms , 2013, The neuroradiology journal.

[20]  Susan M. Chang,et al.  Computer-aided detection of radiation-induced cerebral microbleeds on susceptibility-weighted MR images☆ , 2013, NeuroImage: Clinical.

[21]  D. Liebeskind,et al.  Cerebral Microbleeds After Use of Extracorporeal Membrane Oxygenation in Children , 2013, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[22]  Ann M. Peiffer,et al.  Radiation-induced brain injury: A review , 2012, Front. Oncol..

[23]  Susan M. Chang,et al.  7-Tesla susceptibility-weighted imaging to assess the effects of radiotherapy on normal-appearing brain in patients with glioma. , 2012, International journal of radiation oncology, biology, physics.

[24]  E. Pirraglia,et al.  Effects of surgery on cortical atrophy , 2011, Alzheimer's & Dementia.

[25]  Susan M. Chang,et al.  GRAPPA-based susceptibility-weighted imaging of normal volunteers and patients with brain tumor at 7 T. , 2009, Magnetic resonance imaging.

[26]  Yue Cao,et al.  Radiation-induced changes in normal-appearing white matter in patients with cerebral tumors: a diffusion tensor imaging study. , 2008, International journal of radiation oncology, biology, physics.

[27]  M. Noseworthy,et al.  Diffusion tensor imaging of white matter after cranial radiation in children for medulloblastoma: correlation with IQ. , 2006, Neuro-oncology.

[28]  W. Bradley MR appearance of hemorrhage in the brain. , 1993, Radiology.

[29]  Susan M. Chang,et al.  The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with glioma. , 2016, Neuro-oncology.

[30]  D. Kondziolka,et al.  Leukoencephalopathy after whole‐brain radiation therapy plus radiosurgery versus radiosurgery alone for metastatic lung cancer , 2013, Cancer.

[31]  P. Valk,et al.  Radiation injury of the brain. , 1991, AJNR. American journal of neuroradiology.