Screening for lung cancer: Individualized benefit by risk indicators for the first round of screening

7064 Background: The I-ELCAP investigators at 35 institutions throughout the world have been performing CT screening for lung cancer to evaluate its usefulness and to determine the benefit of undergoing the first round of screening given a person’s individual risk indicators. Methods: Baseline screening has been performed on 27,701 high-risk men and women (age, smoking history) between 1993–2004. A lung cancer diagnosis was classified as a baseline screen-diagnosed case if the work-up was prompted by a positive result on the initial CT. Prevalence of lung cancer on baseline screening was determined by age (40–49, 50–74, 75+ years) and smoking history (1–29, 30–59, 60+ pack-years). Kaplan-Meier analysis was applied to resected cases of lung cancers of Stage I to determine lung cancer case-fatality rate. The benefit of a single round of screening was determined by the estimated probability of detecting a lung cancer, of it being of Stage I, of being cured of the cancer following its resection and not dying ...