Gold nanofingers for molecule trapping and detection.

Here we demonstrate a molecular trap structure that can be formed to capture analyte molecules in solution for detection and identification. The structure is based on gold-coated nanoscale polymer fingers made by nanoimprinting technique. The nanofingers are flexible and their tips can be brought together to trap molecules, while at the same time the gold-coated fingertips form a reliable Raman hot spot for molecule detection and identification based on surface enhanced Raman spectroscopy (SERS). The molecule self-limiting gap size control between fingertips ensures ultimate SERS enhancement for sensitive molecule detection. Furthermore, these type of structures, resulting from top-down meeting self-assembly, can be generalized for other applications, such as plasmonics, meta-materials, and other nanophotonic systems.

[1]  Nader Engheta,et al.  Circuits with Light at Nanoscales: Optical Nanocircuits Inspired by Metamaterials , 2007, Science.

[2]  Dinesh Chandra,et al.  Capillary-force-induced clustering of micropillar arrays: is it caused by isolated capillary bridges or by the lateral capillary meniscus interaction force? , 2009, Langmuir : the ACS journal of surfaces and colloids.

[3]  R. Stanley Williams,et al.  Silver-coated Si nanograss as highly sensitive surface-enhanced Raman spectroscopy substrates , 2009 .

[4]  M. Moskovits Surface‐enhanced Raman spectroscopy: a brief retrospective , 2005 .

[5]  S. Shibata,et al.  Top-gathering pillar array of hybrid organic–inorganic material by means of self-organization , 2006 .

[6]  J. F. Stoddart,et al.  Nanoscale molecular-switch crossbar circuits , 2003 .

[7]  Eric Mazur,et al.  Femtosecond laser-nanostructured substrates for surface-enhanced Raman scattering. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[8]  Yung Doug Suh,et al.  Nanogap-engineerable Raman-active nanodumbbells for single-molecule detection. , 2010, Nature materials.

[9]  H. Atwater,et al.  Polarization-selective plasmon-enhanced silicon quantum-dot luminescence. , 2006, Nano letters (Print).

[10]  R Stanley Williams,et al.  Cones fabricated by 3D nanoimprint lithography for highly sensitive surface enhanced Raman spectroscopy , 2010, Nanotechnology.

[11]  Dana D. Dlott,et al.  Measurement of the Distribution of Site Enhancements in Surface-Enhanced Raman Scattering , 2008, Science.

[12]  Steven R. Emory,et al.  Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering , 1997, Science.

[13]  R. V. Van Duyne,et al.  Probing the structure of single-molecule surface-enhanced Raman scattering hot spots. , 2008, Journal of the American Chemical Society.

[14]  Peter Nordlander,et al.  Electromigrated nanoscale gaps for surface-enhanced Raman spectroscopy. , 2007, Nano letters.

[15]  David R. Smith,et al.  Controlling Electromagnetic Fields , 2006, Science.

[16]  Louis E. Brus,et al.  Single Molecule Raman Spectroscopy at the Junctions of Large Ag Nanocrystals , 2003 .

[17]  R. V. Duyne,et al.  Nanosphere lithography: A materials general fabrication process for periodic particle array surfaces , 1995 .

[18]  Peidong Yang,et al.  Tunable plasmonic lattices of silver nanocrystals. , 2007, Nature nanotechnology.