Industrial use thermoplastic microballoon to mimic the contrast agents and its in-vitro behavior including released gas dynamics

Industrial use thermoplastic microballoon having similar size and property is used to mimic the microballoon contrast agent for in vitro study. It reproduces almost of their sonic behaviors including shell breakage, gas release, and dissolving disappearance of the micro gas-bubble. The gas dynamics is very well visible in normal and harmonic, color and B-modes, also gives a noise-like pseudo-Doppler signal that the real microballoon agents gives. It is suggested that a certain correction should be necessary for this additional spectrum broadening due to such micro-bubble dynamics, in contrast enhanced Doppler measurement with real agent in real environment.