Implantable Wireless Telemetry Boards for In Vivo Transocular Transmission

We report live animal studies that verify and quantify successful transocular transmission of data from a miniature low-power implant. To minimize damage, implantation within layers of the eye requires an ultrasmall device on a scale of just a few millimeters on each side and less than 500 mum in thickness. A high-frequency transmitter integrated circuit (IC) was designed, fabricated, and bonded onto a board containing an antenna, matching network components, and interconnects. The transmitter must achieve sufficient efficiency to draw minimal power from the limited onboard storage array while outputting a sufficiently large signal to overcome tissue-induced attenuation. Two different versions of the system were developed, one using a low-temperature co-fired ceramic material for the substrate and the other using silicon. Animal studies performed using live rabbits followed by empirical measurements verified the feasibility of a wireless telemetry scheme for a low-power miniature ocular implant.

[1]  P. Strevens Iii , 1985 .

[2]  Theodore S. Rappaport,et al.  Wireless communications - principles and practice , 1996 .

[3]  Thomas H. Lee,et al.  The Design of CMOS Radio-Frequency Integrated Circuits: RF CIRCUITS THROUGH THE AGES , 2003 .

[4]  Xun Gong,et al.  Magnetically aligned anisotropic conductive adhesive for high-frequency interconnects , 2005, IEEE MTT-S International Microwave Symposium Digest, 2005..

[5]  Joseph F Rizzo,et al.  Biocompatibility of materials implanted into the subretinal space of Yucatan pigs. , 2006, Investigative ophthalmology & visual science.

[6]  P. Andreani,et al.  On the use of MOS varactors in RF VCOs , 2000, IEEE Journal of Solid-State Circuits.

[7]  J. R. James,et al.  Mobile Antenna Systems Handbook , 2001 .

[8]  E. Meng,et al.  Flexible Parylene Packaged Intraocular Coil for Retinal Prostheses , 2006, 2006 International Conference on Microtechnologies in Medicine and Biology.

[9]  Ali Hajimiri,et al.  A general theory of phase noise in electrical oscillators , 1998 .

[10]  T.H. Lee,et al.  Phase noise in CMOS differential LC oscillators , 1998, 1998 Symposium on VLSI Circuits. Digest of Technical Papers (Cat. No.98CH36215).

[11]  R. Timothy Hitchcock,et al.  Radio-Frequency and ELF Electromagnetic Energies: A Handbook for Health Professionals , 1994 .

[12]  H. Quigley,et al.  The number of people with glaucoma worldwide in 2010 and 2020 , 2006, British Journal of Ophthalmology.

[13]  William J. Chappell,et al.  Miniature antenna for RF telemetry through ocular tissue , 2008, 2008 IEEE MTT-S International Microwave Symposium Digest.