Notch Signaling and the Breast Cancer Microenvironment.

[1]  S. Hurvitz,et al.  Advances in Targeted Therapies for Triple-Negative Breast Cancer , 2019, Drugs.

[2]  J. Jonkers,et al.  Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment , 2018, Cancer and Metastasis Reviews.

[3]  L. Boersma,et al.  Moving Breast Cancer Therapy up a Notch , 2018, Front. Oncol..

[4]  D. Argyle,et al.  Targeting Macrophage-Recruiting Chemokines as a Novel Therapeutic Strategy to Prevent the Progression of Solid Tumors , 2018, Front. Immunol..

[5]  S. Pitson,et al.  The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity , 2018, Front. Oncol..

[6]  Yingying Zhang,et al.  TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma cells via the SMAD2/3 signalling pathway , 2018, International journal of molecular medicine.

[7]  B. Bedogni,et al.  Inhibiting Notch1 enhances immunotherapy efficacy in melanoma by preventing Notch1 dependent immune suppressive properties. , 2018, Cancer letters.

[8]  M. Dieci,et al.  Immune characterization of breast cancer metastases: prognostic implications , 2018, Breast Cancer Research.

[9]  Jennifer L. Guerriero Macrophages: The Road Less Traveled, Changing Anticancer Therapy. , 2018, Trends in molecular medicine.

[10]  R. Weinberg,et al.  Understanding the tumor immune microenvironment (TIME) for effective therapy , 2018, Nature Medicine.

[11]  K. Eisenmann,et al.  Carcinoma associated fibroblasts (CAFs) promote breast cancer motility by suppressing mammalian Diaphanous-related formin-2 (mDia2) , 2018, PloS one.

[12]  K. D. de Visser,et al.  Cancer‐Cell‐Intrinsic Mechanisms Shaping the Tumor Immune Landscape , 2018, Immunity.

[13]  A. Kulkarni,et al.  γ‐Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma , 2018, International journal of cancer.

[14]  Xiulan Zhao,et al.  Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion , 2018, Molecular Cancer.

[15]  A. Bardia,et al.  Targeted therapy for metastatic triple negative breast cancer: The next frontier in precision oncology , 2017, Oncotarget.

[16]  G. Curigliano,et al.  Notch inhibitors and their role in the treatment of triple negative breast cancer: promises and failures , 2017, Current opinion in oncology.

[17]  M. V. D. van den Brink,et al.  Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors , 2017, The Journal of Immunology.

[18]  H. Berman,et al.  Notch Shapes the Innate Immunophenotype in Breast Cancer. , 2017, Cancer discovery.

[19]  Zhipeng Wang,et al.  Jagged1 promotes aromatase inhibitor resistance by modulating tumor-associated macrophage differentiation in breast cancer patients , 2017, Breast Cancer Research and Treatment.

[20]  S. Domchek,et al.  Immunotherapy for Breast Cancer: What Are We Missing? , 2017, Clinical Cancer Research.

[21]  Zhen-ning Wang,et al.  Mechanism of immune evasion in breast cancer , 2017, OncoTargets and therapy.

[22]  Yi Zhang,et al.  Tumor-associated macrophages: from basic research to clinical application , 2017, Journal of Hematology & Oncology.

[23]  M. Moran,et al.  Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer , 2017, Oncogene.

[24]  F. Nicoletti,et al.  Anti-angiogenic Therapy in Cancer: Downsides and New Pivots for Precision Medicine , 2017, Front. Pharmacol..

[25]  M. D. Palma Origins of Brain Tumor Macrophages. , 2016 .

[26]  Carlos Caldas,et al.  Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study , 2016, PLoS medicine.

[27]  Shaojiang Zheng,et al.  Inhibition of Notch Signaling Attenuates Schistosomiasis Hepatic Fibrosis via Blocking Macrophage M2 Polarization , 2016, PloS one.

[28]  A. Azad,et al.  Notch and TGFβ form a positive regulatory loop and regulate EMT in epithelial ovarian cancer cells. , 2016, Cellular signalling.

[29]  S. Rosochacki,et al.  Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs , 2016, Journal of enzyme inhibition and medicinal chemistry.

[30]  J. Kitajewski,et al.  In vitro modeling of endothelial interaction with macrophages and pericytes demonstrates Notch signaling function in the vascular microenvironment , 2016, Angiogenesis.

[31]  L. Ivashkiv,et al.  RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes , 2016, Protein & Cell.

[32]  Shiying Yu,et al.  Notch signaling: an emerging therapeutic target for cancer treatment. , 2015, Cancer letters.

[33]  Michael Kahn,et al.  Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update , 2015, Nature Reviews Clinical Oncology.

[34]  T. Rőszer,et al.  Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms , 2015, Mediators of inflammation.

[35]  You Wang,et al.  Elevated expression of USP9X correlates with poor prognosis in human non-small cell lung cancer. , 2015, Journal of thoracic disease.

[36]  Annelie Abrahamsson,et al.  CCL2 and CCL5 Are Novel Therapeutic Targets for Estrogen-Dependent Breast Cancer , 2015, Clinical Cancer Research.

[37]  Jianfeng Zhou,et al.  Targeting of the deubiquitinase USP9X attenuates B-cell acute lymphoblastic leukemia cell survival and overcomes glucocorticoid resistance. , 2015, Biochemical and biophysical research communications.

[38]  H. Tsukamoto,et al.  NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. , 2015, The Journal of clinical investigation.

[39]  C. Mathers,et al.  Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 , 2015, International journal of cancer.

[40]  J. Morales-Montor,et al.  The role of cytokines in breast cancer development and progression. , 2015, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[41]  H. Ishwaran,et al.  Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways , 2014, Cell.

[42]  F M Blows,et al.  Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients. , 2014, Annals of oncology : official journal of the European Society for Medical Oncology.

[43]  M. Simon,et al.  Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment. , 2014, Trends in cell biology.

[44]  Will Liao,et al.  The cellular and molecular origin of tumor-associated macrophages , 2014, Science.

[45]  Hong Yang,et al.  Notch-1 Signaling Promotes the Malignant Features of Human Breast Cancer through NF-κB Activation , 2014, PloS one.

[46]  Jorge Joven,et al.  CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile , 2014, The Journal of Immunology.

[47]  J. Sage,et al.  From fly wings to targeted cancer therapies: a centennial for notch signaling. , 2014, Cancer cell.

[48]  Tom C. Freeman,et al.  Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation , 2014, Immunity.

[49]  H. Schreiber,et al.  Innate and adaptive immune cells in the tumor microenvironment , 2013, Nature Immunology.

[50]  Freddy Radtke,et al.  Regulation of innate and adaptive immunity by Notch , 2013, Nature Reviews Immunology.

[51]  Jeffrey L. Wrana,et al.  High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer , 2013, Proceedings of the National Academy of Sciences.

[52]  Jean Daudelin,et al.  Notch signaling regulates PD‐1 expression during CD8+ T‐cell activation , 2013, Immunology and cell biology.

[53]  T. Hagemann,et al.  The tumor microenvironment at a glance , 2012, Journal of Cell Science.

[54]  M. Kirschner,et al.  Deubiquitinase FAM/USP9X Interacts with the E3 Ubiquitin Ligase SMURF1 Protein and Protects It from Ligase Activity-dependent Self-degradation , 2012, The Journal of Biological Chemistry.

[55]  F. Bunz,et al.  Genetic disruption of USP9X sensitizes colorectal cancer cells to 5-fluorouracil , 2012, Cancer biology & therapy.

[56]  Karin Jirström,et al.  The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients , 2012, BMC Cancer.

[57]  W. Ye,et al.  CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. , 2012, Cancer research.

[58]  M. Reedijk,et al.  Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications. , 2012, Cancer letters.

[59]  C. Blobel,et al.  Notch-RBP-J Signaling Regulates IRF8 to Promote Inflammatory Macrophage Polarization , 2012, Nature Immunology.

[60]  Douglas Hanahan,et al.  Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment Prospects and Obstacles for Therapeutic Targeting of Function-enabling Stromal Cell Types , 2022 .

[61]  Z. Werb,et al.  Extracellular matrix degradation and remodeling in development and disease. , 2011, Cold Spring Harbor perspectives in biology.

[62]  I. Ellis,et al.  Tumour-infiltrating macrophages and clinical outcome in breast cancer , 2011, Journal of Clinical Pathology.

[63]  Kornelia Polyak,et al.  Heterogeneity in breast cancer. , 2011, The Journal of clinical investigation.

[64]  D. Carbone,et al.  Resuscitating cancer immunosurveillance: selective stimulation of DLL1-Notch signaling in T cells rescues T-cell function and inhibits tumor growth. , 2011, Cancer research.

[65]  Ziyan Wang,et al.  TRB3 interacts with SMAD3 promoting tumor cell migration and invasion , 2011, Journal of Cell Science.

[66]  J. Kitajewski,et al.  Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice. , 2011, Blood.

[67]  J. Bussink,et al.  Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response , 2011, Breast Cancer Research.

[68]  Ian O Ellis,et al.  Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[69]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[70]  Yibin Kang,et al.  Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. , 2011, Cancer cell.

[71]  J. Kitajewski,et al.  Notch1 Deficiency Results in Decreased Inflammation during Wound Healing and Regulates Vascular Endothelial Growth Factor Receptor-1 and Inflammatory Cytokine Expression in Macrophages , 2010, The Journal of Immunology.

[72]  M. Watanabe,et al.  Regulatory T cells and breast cancer: implications for immunopathogenesis , 2010, Cancer and Metastasis Reviews.

[73]  E. Giannoni,et al.  Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. , 2010, Cancer research.

[74]  J. Dering,et al.  Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer , 2010, Breast Cancer Research and Treatment.

[75]  P. De Baetselier,et al.  Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. , 2010, Cancer research.

[76]  Xingbin Hu,et al.  Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses. , 2010, Cancer Research.

[77]  M. Shimada,et al.  Notch2 Signaling Is Required for Potent Antitumor Immunity In Vivo , 2010, The Journal of Immunology.

[78]  Kristian Pietras,et al.  Hallmarks of cancer: interactions with the tumor stroma. , 2010, Experimental cell research.

[79]  Louis Vermeulen,et al.  Wnt activity defines colon cancer stem cells and is regulated by the microenvironment , 2010, Nature Cell Biology.

[80]  Jeffrey W. Pollard,et al.  Macrophage Diversity Enhances Tumor Progression and Metastasis , 2010, Cell.

[81]  M. Karin,et al.  Immunity, Inflammation, and Cancer , 2010, Cell.

[82]  M. Shimoda,et al.  Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression , 2010, Seminars in cell & developmental biology.

[83]  Jan Kitajewski,et al.  Notch regulates the angiogenic response via induction of VEGFR-1 , 2010, Journal of angiogenesis research.

[84]  J. Griffin,et al.  Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion , 2009, British Journal of Cancer.

[85]  K. Mimori,et al.  Abnormal expression of TRIB3 in colorectal cancer: a novel marker for prognosis , 2009, British Journal of Cancer.

[86]  Y. Lévy,et al.  Notch Increases T/NK Potential of Human Hematopoietic Progenitors and Inhibits B Cell Differentiation at a Pro‐B Stage , 2009, Stem cells.

[87]  David J. Mooney,et al.  Growth Factors, Matrices, and Forces Combine and Control Stem Cells , 2009, Science.

[88]  A. Gilmore,et al.  Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. , 2009, Cancer research.

[89]  Jixin Ding,et al.  Insulin regulates TRB3 and other stress-responsive gene expression through induction of C/EBPbeta. , 2009, Molecular endocrinology.

[90]  T. Golde,et al.  Notch Regulates Cytolytic Effector Function in CD8+ T Cells1 , 2009, Journal of Immunology.

[91]  G. Núñez,et al.  The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis , 2009, Nature Immunology.

[92]  Pier Paolo Di Fiore,et al.  The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer , 2009, Nature Cell Biology.

[93]  Leonardo Morsut,et al.  FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination , 2009, Cell.

[94]  J. Edwards,et al.  Exploring the full spectrum of macrophage activation , 2008, Nature Reviews Immunology.

[95]  C. Hsieh,et al.  A functional Notch–survivin gene signature in basal breast cancer , 2008, Breast Cancer Research.

[96]  Jiahuai Han,et al.  Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. , 2008, Immunity.

[97]  T. Rosol,et al.  Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. , 2008, Cancer Research.

[98]  Anna Marie Mulligan,et al.  JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer , 2008, Breast Cancer Research and Treatment.

[99]  T. Golde,et al.  ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a γ-secretase inhibitor , 2008, Oncogene.

[100]  D. Altieri,et al.  Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis. , 2008, Cancer research.

[101]  Chindo Hicks,et al.  Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. , 2008, Cancer research.

[102]  P. Allavena,et al.  Cancer-related inflammation , 2008, Nature.

[103]  S. Bull,et al.  Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors , 2008, Breast Cancer Research and Treatment.

[104]  Shinya Watanabe,et al.  NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells. , 2008, Cancer research.

[105]  Adrian L Harris,et al.  Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. , 2008, Microvascular research.

[106]  D. Noonan,et al.  Inflammation, inflammatory cells and angiogenesis: decisions and indecisions , 2008, Cancer and Metastasis Reviews.

[107]  S. Kaufmann,et al.  Notch signaling is activated by TLR stimulation and regulates macrophage functions , 2008, European journal of immunology.

[108]  D. Santini,et al.  IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. , 2007, The Journal of clinical investigation.

[109]  N. Yoo,et al.  Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias , 2007, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[110]  A. Karsan,et al.  Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. , 2007, The Journal of experimental medicine.

[111]  Daniel Birnbaum,et al.  ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. , 2007, Cell stem cell.

[112]  M. Skobe,et al.  Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. , 2007, The Journal of clinical investigation.

[113]  R. Adams,et al.  Regulation of vascular morphogenesis by Notch signaling. , 2007, Genes & development.

[114]  D. Ord,et al.  TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4. , 2007, Experimental cell research.

[115]  T. Gridley Notch signaling in vascular development and physiology , 2007, Development.

[116]  G. Weinmaster,et al.  Notch Signaling – Constantly on the Move , 2007, Traffic.

[117]  E. Gautier,et al.  Enhanced Immune System Activation and Arterial Inflammation Accelerates Atherosclerosis in Lupus-Prone Mice , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[118]  J. Aster,et al.  Delta-Like 4 Induces Notch Signaling in Macrophages: Implications for Inflammation , 2007, Circulation.

[119]  G. Lockwood,et al.  High-level JAG1 mRNA and protein predict poor outcome in breast cancer , 2007, Modern Pathology.

[120]  N. Anderson,et al.  Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. , 2007, Journal of the National Cancer Institute.

[121]  Arndt F. Siekmann,et al.  Notch Signalling and the Regulation of Angiogenesis , 2007, Cell adhesion & migration.

[122]  D. Santini,et al.  p66Shc/Notch‐3 Interplay Controls Self‐Renewal and Hypoxia Survival in Human Stem/Progenitor Cells of the Mammary Gland Expanded In Vitro as Mammospheres , 2007, Stem cells.

[123]  Antonio Duarte,et al.  The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching , 2007, Proceedings of the National Academy of Sciences.

[124]  Gavin Thurston,et al.  Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis , 2006, Nature.

[125]  Stephen B Fox,et al.  Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[126]  Xia Zhang,et al.  Biochemical and functional characterization of three activated macrophage populations , 2006, Journal of leukocyte biology.

[127]  Xia Zhang,et al.  Dynamic and Transient Remodeling of the Macrophage IL-10 Promoter during Transcription1 , 2006, The Journal of Immunology.

[128]  J. Yates,et al.  TRB3 Links the E3 Ubiquitin Ligase COP1 to Lipid Metabolism , 2006, Science.

[129]  A. Klippel,et al.  TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. , 2006, Cellular signalling.

[130]  Raghu Kalluri,et al.  Fibroblasts in cancer , 2006, Nature Reviews Cancer.

[131]  M. Lupien,et al.  Tumorigenesis and Neoplastic Progression Overexpression of Activated Murine Notch 1 and Notch 3 in Transgenic Mice Blocks Mammary Gland Development and Induces Mammary Tumors , 2022 .

[132]  J. Quigley,et al.  Matrix metalloproteinases and tumor metastasis , 2006, Cancer and Metastasis Reviews.

[133]  A. Bauer,et al.  Regulation of Notch signalling by non-visual β-arrestin , 2005, Nature Cell Biology.

[134]  Peter Carmeliet,et al.  VEGF as a Key Mediator of Angiogenesis in Cancer , 2005, Oncology.

[135]  G. Lockwood,et al.  High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. , 2005, Cancer research.

[136]  Danila Coradini,et al.  Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. , 2005, Cancer research.

[137]  T. Giordano,et al.  Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. , 2005, Cancer cell.

[138]  A. Papanikolaou,et al.  Cyclin D1 in breast cancer pathogenesis. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[139]  Dennis C. Sgroi,et al.  Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion , 2005, Cell.

[140]  G. Watkins,et al.  Expression of the Transcription Factors Snail, Slug, and Twist and Their Clinical Significance in Human Breast Cancer , 2005, Annals of Surgical Oncology.

[141]  H. Hayashi,et al.  TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death , 2005, The EMBO journal.

[142]  Yi-Chen Lin,et al.  Tumor-associated macrophages: the double-edged sword in cancer progression. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[143]  Bart Landuyt,et al.  Vascular Endothelial Growth Factor and Angiogenesis , 2004, Pharmacological Reviews.

[144]  K. Jones,et al.  Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. , 2004, Molecular cell.

[145]  H. Moses,et al.  Stromal fibroblasts in cancer initiation and progression , 2004, Nature.

[146]  G. Watkins,et al.  The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. , 2004, International journal of molecular medicine.

[147]  Andrew P. Weng,et al.  Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia , 2004, Science.

[148]  G. Dontu,et al.  Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells , 2004, Breast Cancer Research.

[149]  S. Artavanis-Tsakonas,et al.  Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium. , 2004, The American journal of pathology.

[150]  E. Bruyneel,et al.  Tenascin‐C and SF/HGF produced by myofibroblasts in vitro provide convergent proinvasive signals to human colon cancer cells through RhoA and Rac , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[151]  Hsiu‐Po Wang,et al.  Interleukin-6 increases vascular endothelial growth factor and angiogenesis in gastric carcinoma. , 2004, Journal of biomedical science.

[152]  R. Callahan,et al.  Notch Signaling in Mammary Development and Oncogenesis , 2004, Journal of Mammary Gland Biology and Neoplasia.

[153]  C. McGlade,et al.  Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain* , 2003, Journal of Biological Chemistry.

[154]  G. Dontu,et al.  In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. , 2003, Genes & development.

[155]  S. Scully,et al.  SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia , 2003, Oncogene.

[156]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[157]  Anne Vincent-Salomon,et al.  Epithelial–mesenchymal transition in breast cancer development , 2003 .

[158]  Christopher C W Hughes,et al.  Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. , 2002, Microvascular research.

[159]  W. Hahn,et al.  Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells , 2002, Nature Medicine.

[160]  Daniel R. Foltz,et al.  Glycogen Synthase Kinase-3β Modulates Notch Signaling and Stability , 2002, Current Biology.

[161]  S. Beyer,et al.  c-Cbl Binding and Ubiquitin-dependent Lysosomal Degradation of Membrane-associated Notch1* , 2002, The Journal of Biological Chemistry.

[162]  Rakesh K Jain,et al.  Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. , 2002, The American journal of pathology.

[163]  M. Gurney,et al.  The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog* , 2001, The Journal of Biological Chemistry.

[164]  R. Tibshirani,et al.  Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[165]  R K Jain,et al.  Openings between defective endothelial cells explain tumor vessel leakiness. , 2000, The American journal of pathology.

[166]  G. Gabbiani,et al.  Mechanisms of myofibroblast activity and phenotypic modulation. , 1999, Experimental cell research.

[167]  James M. Roberts,et al.  CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.

[168]  K Anan,et al.  Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer. , 1996, Surgery.

[169]  H. Dvorak,et al.  Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. , 1995, The American journal of pathology.

[170]  H. Rodemann,et al.  Characterization of human renal fibroblasts in health and disease: II. In vitro growth, differentiation, and collagen synthesis of fibroblasts from kidneys with interstitial fibrosis. , 1991, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[171]  W. Schürch,et al.  Smooth‐muscle differentiation in stromal cells of malignant and non‐malignant breast tissues , 1988, International journal of cancer.

[172]  D. Gallahan,et al.  Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors , 1987, Journal of virology.

[173]  D. Gallahan,et al.  A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17 , 1987, Journal of virology.

[174]  Weifeng Yu,et al.  Notch signaling pathway dampens tumor-infiltrating CD8+ T cells activity in patients with colorectal carcinoma. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[175]  M. Reedijk Notch signaling and breast cancer. , 2012, Advances in experimental medicine and biology.

[176]  H. Berman,et al.  Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer. , 2011, Cancer research.

[177]  Carsten Denkert,et al.  Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[178]  A. Celada,et al.  Macrophage activation: classical versus alternative. , 2009, Methods in molecular biology.

[179]  N. Harbeck,et al.  uPA and PAI-1 in breast cancer: review of their clinical utility and current validation in the prospective NNBC-3 trial. , 2008, Advances in clinical chemistry.

[180]  D. Altieri Survivin, cancer networks and pathway-directed drug discovery , 2008, Nature Reviews Cancer.

[181]  F. Mitjans,et al.  Angiogenesis Switch Pathways , 2008 .

[182]  R. Callahan,et al.  Notch Signaling in Mammary Gland Tumorigenesis , 2004, Journal of Mammary Gland Biology and Neoplasia.

[183]  Frank McCormick,et al.  Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. , 2004, Genes & development.

[184]  Cheol‐Hee Kim,et al.  Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. , 2003, Developmental cell.

[185]  H. Shepard,et al.  Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α , 1987, Nature.