[123I]β‐CIT single‐photon emission tomography in DOPA‐responsive dystonia

The radiotracer [123I]β‐CIT is a sensitive marker of dopamine uptake sites that can be used to visualize dopaminergic nerve endings in vivo in the human brain. We report on [123I]β‐CIT single‐photon emission computed tomography (SPECT) findings in a patient with DOPA‐responsive dystonia (DRD). [123I]β‐CIT SPECT showed a striatal radiotracer uptake in the upper range of normal, indicating intact dopamine transporters and structural integrity of nigrostriatal neurons. This differentiates DRD from clinically similar cases with juvenile‐onset parkinsonism with dystonia that have a considerably poorer prognosis. [123I]β‐CIT SPECT may provide a method equally as useful as fluorodopa positron emission tomography in DRD.

[1]  C D Marsden,et al.  Dopa‐responsive dystonia , 1991, Neurology.

[2]  C. Marsden,et al.  Dopa-responsive dystonia. , 1994, Annals of neurology.

[3]  C D Marsden,et al.  Dopa‐responsive dystonia: [18F]dopa positron emission tomography , 1991, Annals of neurology.

[4]  Hirohide Takahashi,et al.  Positron emission tomographic studies of dopa‐responsive dystonia and early‐onset idiopathic parkinsonism , 1993, Annals of neurology.

[5]  C. Marsden,et al.  Comparison of striatal 18F‐dopa uptake in adult‐onset dystonia‐parkinsonism, Parkinson's disease, and dopa‐responsive dystonia , 1993, Neurology.

[6]  P B Hoffer,et al.  [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain. , 1991, Journal of medicinal chemistry.

[7]  M. Segawa,et al.  Hereditary progressive dystonia with marked diurnal fluctuation: clinicopathophysiological identification in reference to juvenile Parkinson's disease. , 1987, Advances in neurology.

[8]  James T. Elder,et al.  Scanning chromosome 17 for psoriasis susceptibility: lack of evidence for a distal 17q locus. , 1995, Human heredity.

[9]  Stanley Fahn,et al.  Linkage mapping of dopa–responsive dystonia (DRD) to chromosome 14q , 1993, Nature Genetics.

[10]  S. Tsuji,et al.  Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene , 1994, Nature Genetics.

[11]  M Laruelle,et al.  Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[12]  R. Levine,et al.  Biochemical and fluorodopa positron emission tomographic findings in an asymptomatic carrier of the gene for dopa‐responsive dystonia , 1994, Annals of neurology.

[13]  Y. Mizuno,et al.  A clue to the pathogenesis of dopa‐responsive dystonia , 1995, Annals of neurology.

[14]  Eileen O. Smith,et al.  Decreased single‐photon emission computed tomographic {123I}β‐CIT striatal uptake correlates with symptom severity in parkinson's disease , 1995, Annals of neurology.

[15]  E. Trabetti,et al.  Forensic applications of molecular genetic analysis: an Italian collaborative study on paternity testing by the determination of variable number of tandem repeat DNA polymorphisms. , 1991, Human heredity.

[16]  W. Gibb,et al.  Dopa‐responsive dystonia: Pathological and biochemical observations in a case , 1994, Annals of neurology.

[17]  L. Deecke,et al.  D2 Receptor Blockade by Flunarizine and Cinnarizine Explains Extrapyramidal Side Effects. A SPECT Study , 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.