Separation of sodium and calcium currents in the somatic membrane of mollusc neurones. With an Appendix by Yu A. Shakhovalov

1. Characteristics of the transmembrane ionic currents under controlled changes in ionic composition of extra‐ and intracellular medium were studied in isolated neurones from the ganglia of molluscs, Helix pomatia, Limnea stagnalis and Planorbis corneus. The neurones were investigated by a new technique which allows for dialysis of their interior and for clamping of the potential at the surface membrane without using micro‐electrodes.

[1]  N. Standen Voltage‐clamp studies of the calcium inward current in an identified snail neurone: comparison with the sodium inward current. , 1975, The Journal of physiology.

[2]  D. Junge,et al.  Sodium and calcium components of action potentials in Aplysia giant neurone , 1968, The Journal of physiology.

[3]  B. Katz,et al.  The timing of calcium action during neuromuscular transmission , 1967, The Journal of physiology.

[4]  M. Tarr Two Inward Currents in Frog Atrial Muscle , 1971, The Journal of general physiology.

[5]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1952, The Journal of physiology.

[6]  R. Eckert,et al.  A non-inactivating inward current recorded during small depolarizing voltage steps in snail pacemaker neurons , 1975, Brain Research.

[7]  R. Keynes,et al.  Calcium and potassium systems of a giant barnacle muscle fibre under membrane potential control , 1973, The Journal of physiology.

[8]  A. Hodgkin,et al.  Depolarization and calcium entry in squid giant axons , 1971, The Journal of physiology.

[9]  O. Krishtal,et al.  Outward currents in isolated snail neurones—II. Effect of TEA , 1975 .

[10]  H. Meves,et al.  Calcium inward currents in internally perfused giant axons , 1973, The Journal of physiology.

[11]  R. Eckert,et al.  A voltage‐sensitive persistent calcium conductance in neuronal somata of Helix. , 1976, The Journal of physiology.

[12]  E. B. Ridgway,et al.  Calcium entry in response to maintained depolarization of squid axons , 1973, The Journal of physiology.

[13]  S. Hagiwara,et al.  Membrane Currents Carried by Ca, Sr, and Ba in Barnacle Muscle Fiber During Voltage Clamp , 1974, The Journal of general physiology.

[14]  R. Eckert,et al.  Inferred slow inward current in snail neurones , 1974, Nature.

[15]  R. Gruener,et al.  Voltage clamp of the Aplysia giant neurone: early sodium and calcium currents , 1970, The Journal of physiology.